PMID- 31280499
OWN - NLM
STAT- MEDLINE
DCOM- 20200203
LR  - 20200203
IS  - 1939-165X (Electronic)
IS  - 0275-6382 (Linking)
VI  - 48
IP  - 3
DP  - 2019 Sep
TI  - Hypoglycemia associated with disseminated metastatic tonsillar squamous cell 
      carcinoma producing insulin-like growth factor-I in a Pomeranian dog.
PG  - 429-434
LID - 10.1111/vcp.12753 [doi]
AB  - A 13-year-old spayed female Pomeranian dog was presented for persistent, severe 
      hypoglycemia (37 mg/dL; reference interval [RI] 75-128 mg/dL). Progressive 
      nonregenerative anemia (hematocrit 23.3%-15.9%; RI 37.0%-55.0%) and severe 
      thrombocytopenia (36 000/microL; RI 200-500 000/microL) were also noted. The serum 
      insulin concentration was low (0.24 ng/mL; RI 0.302-1.277 ng/mL). Computed 
      tomography revealed multiple splenic nodules (1-6 mm in diameter) and several 
      hepatic nodules (7.6, 12 mm in diameter). Ultrasound-guided fine-needle 
      aspiration of the splenic and hepatic nodules revealed low numbers of epithelial 
      cells with mild cellular atypia, suggestive of a metastatic epithelial tumor, but 
      the primary site was unknown at that time. On careful oral examination under 
      general anesthesia, an enlarged right tonsil was noted grossly, and 
      histopathologic examination of the tonsil diagnosed squamous cell carcinoma. Bone 
      marrow aspirates and biopsies of the splenic and hepatic nodules were performed; 
      all samples were diagnosed as metastatic carcinoma on histopathologic 
      examination. No nodules were present in the pancreas, despite careful palpation 
      during exploratory laparotomy. On immunohistochemistry, the neoplastic cells were 
      positive for cytokeratin AE1/3 and insulin-like growth factor (IGF)-I but were 
      negative for chromogranin A, PGP9.5, insulin, and inconclusive for IGF-II. This 
      is the first report of a primary IGF-I-producing squamous cell carcinoma in the 
      tonsil of a dog with metastases to bone marrow, liver, and spleen, resulting in 
      hypoglycemia.
CI  - (c) 2019 American Society for Veterinary Clinical Pathology.
FAU - Azuma, Kazushi
AU  - Azuma K
AD  - Synergy Animal General Hospital, Kawaguchi-shi, Saitama, Japan.
FAU - Asakawa, Makoto
AU  - Asakawa M
AD  - Synergy Animal General Hospital, Kawaguchi-shi, Saitama, Japan.
FAU - Konno, Toshiaki
AU  - Konno T
AD  - Synergy Animal General Hospital, Kawaguchi-shi, Saitama, Japan.
FAU - Fukuda, Shoko
AU  - Fukuda S
AD  - Synergy Animal General Hospital, Kawaguchi-shi, Saitama, Japan.
FAU - Goto Asakawa, Midori
AU  - Goto Asakawa M
AD  - Synergy Animal General Hospital, Kawaguchi-shi, Saitama, Japan.
LA  - eng
PT  - Case Reports
DEP - 20190706
PL  - United States
TA  - Vet Clin Pathol
JT  - Veterinary clinical pathology
JID - 9880575
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Carcinoma, Squamous Cell/diagnostic imaging/metabolism/secondary/*veterinary
MH  - Dog Diseases/diagnostic imaging/*metabolism
MH  - Dogs
MH  - Female
MH  - Hypoglycemia/*etiology/metabolism
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Tonsillar Neoplasms/complications/diagnostic imaging/metabolism/*veterinary
OTO - NOTNLM
OT  - IGFs
OT  - canine
OT  - hypoglycemia
OT  - metastasis to the bone marrow
OT  - tonsillar squamous cell carcinoma
EDAT- 2019/07/08 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/07/08 06:00
PHST- 2018/08/25 00:00 [received]
PHST- 2019/01/03 00:00 [revised]
PHST- 2019/01/09 00:00 [accepted]
PHST- 2019/07/08 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/07/08 06:00 [entrez]
AID - 10.1111/vcp.12753 [doi]
PST - ppublish
SO  - Vet Clin Pathol. 2019 Sep;48(3):429-434. doi: 10.1111/vcp.12753. Epub 2019 Jul 6.