PMID- 31281547
OWN - NLM
STAT- MEDLINE
DCOM- 20191210
LR  - 20220409
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2019
DP  - 2019
TI  - Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep 
      Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes.
PG  - 4578327
LID - 10.1155/2019/4578327 [doi]
LID - 4578327
AB  - PURPOSE: We aimed to investigate the association between serum uric acid (SUA) 
      levels and obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients with 
      type 2 diabetes. METHODS: A cross-sectional study of 212 type 2 diabetes mellitus 
      (T2DM) patients was conducted in Xiamen, China. All patients underwent 
      polysomnography (PSG) recordings for OSAHS diagnosis. Patients were grouped 
      according to the apnea-hypopnea index (AHI) as mild (5-14.9), moderate (15-29.9), 
      and severe (>==30) OSAHS. Patients with AHI </= 4.9 served as the control group. 
      Weight, body mass index (BMI), SUA, liver function, renal function, blood 
      pressure, lipid profiles, and glycemic parameters were measured. RESULTS: A total 
      of 158 patients (101 men and 57 women) with complete data were analyzed in this 
      study. 127 patients were identified as OSAHS. Among the 127 patients with OSAHS, 
      56 (44.1%), 37 (29.1%), and 34 (26.8%) had mild, moderate, and severe OSAHS, 
      respectively. Correlation analyses showed that the SUA level was significantly 
      related to the apnea-hypopnea index (AHI) (r = 0.194, p = 0.016). The level of 
      SUA was significantly higher among OSAHS patients compared to the control group 
      (control group: 333.14 +/- 80.52 mumol/L, mild group: 345.50 +/- 90.27 mumol/L, 
      moderate group: 363.59 +/- 134.26 mumol/L, and severe group: 428.37 +/- 123.58 mumol/L 
      and p = 0.029). Multivariable logistic regression analyses showed that SUA was 
      the independent risk factor for OSAHS (OR: 1.006, 95% CI: 1.001-1.011, p = 
      0.020). CONCLUSIONS: The SUA level is significantly associated with the severity 
      of OSAHS and should be controlled when managing OSAHS.
FAU - Zheng, Caiyu
AU  - Zheng C
AD  - School of Medicine, Xiamen University, Xiamen, China.
FAU - Song, Haiqu
AU  - Song H
AD  - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen 
      University, Xiamen, China.
FAU - Wang, Shunhua
AU  - Wang S
AD  - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen 
      University, Xiamen, China.
FAU - Liu, Jing
AU  - Liu J
AD  - School of Medicine, Xiamen University, Xiamen, China.
FAU - Lin, Tingting
AU  - Lin T
AD  - The Fujian University of Traditional Chinese Medicine, Fuzhou, China.
FAU - Du, Chunmin
AU  - Du C
AD  - School of Medicine, Xiamen University, Xiamen, China.
FAU - Xie, Huan
AU  - Xie H
AD  - The Fujian University of Traditional Chinese Medicine, Fuzhou, China.
FAU - Chen, Zhongyun
AU  - Chen Z
AD  - The Fujian University of Traditional Chinese Medicine, Fuzhou, China.
FAU - Zheng, Silan
AU  - Zheng S
AD  - School of Medicine, Xiamen University, Xiamen, China.
FAU - Li, Zhibin
AU  - Li Z
AUID- ORCID: 0000-0001-6642-9780
AD  - Xiamen Diabetes Institute, The First Affiliated Hospital, Xiamen University, 
      Xiamen, China.
AD  - Epidemiology Research Unit, The First Affiliated Hospital, Xiamen University, 
      Xiamen, China.
FAU - Li, Xuejun
AU  - Li X
AD  - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen 
      University, Xiamen, China.
AD  - Xiamen Diabetes Institute, The First Affiliated Hospital, Xiamen University, 
      Xiamen, China.
FAU - Liu, Changqin
AU  - Liu C
AUID- ORCID: 0000-0001-8063-7906
AD  - Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen 
      University, Xiamen, China.
AD  - Department of Endocrinology and Diabetes, The Teaching Hospital of Fujian Medical 
      University, Xiamen, China.
LA  - eng
PT  - Journal Article
DEP - 20190403
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers)
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*blood/complications/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sleep Apnea, Obstructive/*blood/epidemiology
MH  - Uric Acid/*blood
PMC - PMC6590532
EDAT- 2019/07/10 06:00
MHDA- 2019/12/18 06:00
PMCR- 2019/04/03
CRDT- 2019/07/09 06:00
PHST- 2018/11/16 00:00 [received]
PHST- 2019/02/14 00:00 [revised]
PHST- 2019/03/07 00:00 [accepted]
PHST- 2019/07/09 06:00 [entrez]
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/04/03 00:00 [pmc-release]
AID - 10.1155/2019/4578327 [doi]
PST - epublish
SO  - Dis Markers. 2019 Apr 3;2019:4578327. doi: 10.1155/2019/4578327. eCollection 
      2019.