PMID- 31281850
OWN - NLM
STAT- MEDLINE
DCOM- 20200218
LR  - 20220409
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2019
DP  - 2019
TI  - Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone 
      Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the 
      Henan Rural Cohort Study.
PG  - 4693817
LID - 10.1155/2019/4693817 [doi]
LID - 4693817
AB  - OBJECTIVE: The aim of the study was to investigate the independent and combined 
      effects of the cortisol-to-cortisone ratio (F/E) and 11-deoxycortisol on 
      prediabetes and type 2 diabetes mellitus (T2DM) among different genders. METHODS: 
      A case-control study was performed including 2676 participants from the Henan 
      Rural Cohort Study. Liquid chromatography-tandem mass spectrometry was used to 
      assess serum cortisol, cortisone, and 11-deoxycortisol. Conditional logistic 
      regression was performed to estimate the associations between hormones and 
      outcomes. RESULTS: After adjusting for multiple variables, the negative 
      associations of F/E and 11-dexyocortisol with T2DM were observed in females (T3 
      vs. T1: OR = 0.56, 95% CI: 0.39-0.80 for F/E; T3 vs. T1: OR = 0.44, 95% CI: 
      0.27-0.73 for 11-dexyocortisol). However, only 11-dexyocortisol showed a negative 
      association with prediabetes both in males and females. Compared with the 
      combination of low F/E and 11-dexyocortisol, the combination of middle F/E and 
      high 11-dexyocortisol was significantly associated with prediabetes (OR = 0.29, 
      95% CI: 0.12-0.71) in males. Furthermore, the combination of high F/E and 
      11-dexyocortisol was associated with the lowest odds of prediabetes (OR = 0.39, 
      95% CI: 0.21-0.73) and T2DM (OR = 0.25, 95% CI: 0.12-0.52) in females. 
      CONCLUSIONS: Serum F/E level was negatively associated with T2DM only in females 
      whereas serum 11-deoxycortisol level was negatively associated with prediabetes 
      in males and with prediabetes and T2DM in females. Additionally, their 
      combination has a synergistic effect on T2DM.
FAU - Liu, Xue
AU  - Liu X
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Jiang, Jingjing
AU  - Jiang J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Liu, Xiaotian
AU  - Liu X
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Luo, Zhicheng
AU  - Luo Z
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Dong, Xiaokang
AU  - Dong X
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Wei, Dandan
AU  - Wei D
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Huo, Wenqian
AU  - Huo W
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Yu, Songcheng
AU  - Yu S
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Li, Linlin
AU  - Li L
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Jin, Shuna
AU  - Jin S
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health, 
      School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, China.
FAU - Wang, Chongjian
AU  - Wang C
AUID- ORCID: 0000-0001-5091-6621
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
FAU - Mao, Zhenxing
AU  - Mao Z
AUID- ORCID: 0000-0001-5171-1169
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, China.
LA  - eng
PT  - Journal Article
DEP - 20190602
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - V27W9254FZ (Cortisone)
RN  - WDT5SLP0HQ (Cortodoxone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Cortisone/*blood
MH  - Cortodoxone/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*blood
MH  - Regression Analysis
MH  - Rural Population
MH  - *Sex Factors
PMC - PMC6589245
EDAT- 2019/07/10 06:00
MHDA- 2020/02/19 06:00
PMCR- 2019/06/02
CRDT- 2019/07/09 06:00
PHST- 2018/11/29 00:00 [received]
PHST- 2019/02/25 00:00 [revised]
PHST- 2019/05/12 00:00 [accepted]
PHST- 2019/07/09 06:00 [entrez]
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2020/02/19 06:00 [medline]
PHST- 2019/06/02 00:00 [pmc-release]
AID - 10.1155/2019/4693817 [doi]
PST - epublish
SO  - J Diabetes Res. 2019 Jun 2;2019:4693817. doi: 10.1155/2019/4693817. eCollection 
      2019.