PMID- 31281913
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20190731
IS  - 1477-9234 (Electronic)
IS  - 1477-9226 (Linking)
VI  - 48
IP  - 30
DP  - 2019 Aug 14
TI  - Enhanced cytotoxicity of indenyl molybdenum(ii) compounds bearing a thiophene 
      function.
PG  - 11361-11373
LID - 10.1039/c9dt01698h [doi]
AB  - A series of six indenyl molybdenum compounds bearing a thiophenyl function in the 
      side chain were prepared and characterized by analytical and spectroscopic 
      methods. The structures of 
      [(eta(5)-C(9)H(6)CH(2)C(4)H(3)S)(eta(3)-C(3)H(5))Mo(CO)(2)] and 
      [(eta(5)-C(9)H(6)CH(2)C(4)H(3)S)Mo(CO)(2)(bpy)][BF(4)] were determined by 
      single-crystal X-ray diffraction. The compounds bearing N,N-chelating ligands 
      exhibit increased cytotoxic activity against human leukemia cell lines MOLT-4; up 
      to two orders of magnitude lower IC(50) values were observed compared to 
      analogues with unsubstituted indenyl, which clearly demonstrates the strong 
      effect of the indenyl ligand modification on the biological activity of the 
      molybdenum(ii) compounds. The highest cytostatic potential was observed for the 
      complex bearing 4,7-diphenyl-1,10-phenanthtoline 
      [(eta(5)-C(9)H(6)CH(2)C(4)H(3)S)Mo(CO)(2)(Ph(2)phen)][BF(4)] with IC(50) (MOLT-4) = 
      0.19 +/- 0.02 muM. Detailed regulation of the molecular and cellular mechanism by 
      this derivative was investigated on the lung carcinoma cell line A549 and 
      compared with the lung fibroblast cell line MRC-5. Rather unusual differences in 
      the effects on tumor and non-tumor cell lines provide a unique insight into the 
      cytostatic action of molybdenum(ii) complexes.
FAU - Mrozek, Ondrej
AU  - Mrozek O
AUID- ORCID: 0000-0002-8251-9687
AD  - Department of General and Inorganic Chemistry, Faculty of Chemical Technology, 
      University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic. 
      jaromir.vinklarek@upce.cz.
FAU - Melounkova, Lucie
AU  - Melounkova L
AUID- ORCID: 0000-0002-3117-5589
AD  - Department of Analytical Chemistry, Faculty of Chemical Technology, University of 
      Pardubice, Studentska 573, 53210 Pardubice, Czech Republic and Department of 
      Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University 
      in Prague, Simkova 870, 500 01 Hradec Kralove, Czech Republic.
FAU - Dostal, Libor
AU  - Dostal L
AUID- ORCID: 0000-0002-5982-1239
AD  - Department of General and Inorganic Chemistry, Faculty of Chemical Technology, 
      University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic. 
      jaromir.vinklarek@upce.cz.
FAU - Cisarova, Ivana
AU  - Cisarova I
AD  - Department of Inorganic Chemistry, Faculty of Science, Charles University in 
      Prague, Hlavova 2030/8, 128 43 Prague 2, Czech Republic.
FAU - Eisner, Ales
AU  - Eisner A
AD  - Department of Analytical Chemistry, Faculty of Chemical Technology, University of 
      Pardubice, Studentska 573, 53210 Pardubice, Czech Republic.
FAU - Havelek, Radim
AU  - Havelek R
AUID- ORCID: 0000-0003-0528-1334
AD  - Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, 
      Charles University in Prague, Simkova 870, 500 01 Hradec Kralove, Czech Republic.
FAU - Peterova, Eva
AU  - Peterova E
AD  - Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, 
      Charles University in Prague, Simkova 870, 500 01 Hradec Kralove, Czech Republic 
      and 2nd Department of Internal Medicine - Gastroenterology, Charles University, 
      Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Czech 
      Republic.
FAU - Honzicek, Jan
AU  - Honzicek J
AUID- ORCID: 0000-0003-1996-614X
AD  - Institute of Chemistry and Technology of Macromolecular Materials, Faculty of 
      Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, 
      Czech Republic.
FAU - Vinklarek, Jaromir
AU  - Vinklarek J
AUID- ORCID: 0000-0002-8466-1951
AD  - Department of General and Inorganic Chemistry, Faculty of Chemical Technology, 
      University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic. 
      jaromir.vinklarek@upce.cz.
LA  - eng
PT  - Journal Article
DEP - 20190708
PL  - England
TA  - Dalton Trans
JT  - Dalton transactions (Cambridge, England : 2003)
JID - 101176026
SB  - IM
EDAT- 2019/07/10 06:00
MHDA- 2019/07/10 06:01
CRDT- 2019/07/09 06:00
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2019/07/10 06:01 [medline]
PHST- 2019/07/09 06:00 [entrez]
AID - 10.1039/c9dt01698h [doi]
PST - ppublish
SO  - Dalton Trans. 2019 Aug 14;48(30):11361-11373. doi: 10.1039/c9dt01698h. Epub 2019 
      Jul 8.