PMID- 3128278 OWN - NLM STAT- MEDLINE DCOM- 19880428 LR - 20190501 IS - 0264-6021 (Print) IS - 1470-8728 (Electronic) IS - 0264-6021 (Linking) VI - 250 IP - 1 DP - 1988 Feb 15 TI - The effects of aging on carbonic anhydrase concentrations in rat liver and skeletal muscle. PG - 303-5 AB - The isoenzymes carbonic anhydrase II (CAII) and III (CAIII) have been measured by radioimmunoassay in the livers of male and female rats aged from 21 to 800 days. No sexual dimorphism at 21 days was found, but from 50 to 400 days both isoenzymes show sexual differences. From 600 days onwards, these differences are less apparent. CAIII concentrations in two 'fast' fibre muscles and one 'slow' fibre muscle have been determined. There is no sexual dimorphism in muscle, but a wide variation between individuals was observed. Fast muscles show maximal CAIII levels at 800 days, whereas in slow muscle the concentration of the isoenzyme is declining at this time. FAU - Jeffery, S AU - Jeffery S AD - Department of Child Health, St. George's Hospital Medical School, London, U.K. FAU - Merry, B J AU - Merry BJ FAU - Holehan, A M AU - Holehan AM FAU - Carter, N D AU - Carter ND LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Biochem J JT - The Biochemical journal JID - 2984726R RN - 0 (Isoenzymes) RN - EC 4.2.1.1 (Carbonic Anhydrases) SB - IM MH - Aging/*metabolism MH - Animals MH - Carbonic Anhydrases/*metabolism MH - Female MH - Isoenzymes/*metabolism MH - Liver/*enzymology MH - Male MH - Muscles/*enzymology MH - Radioimmunoassay MH - Rats MH - Rats, Inbred Strains MH - Sex Factors PMC - PMC1148849 EDAT- 1988/02/15 00:00 MHDA- 1988/02/15 00:01 PMCR- 1988/08/15 CRDT- 1988/02/15 00:00 PHST- 1988/02/15 00:00 [pubmed] PHST- 1988/02/15 00:01 [medline] PHST- 1988/02/15 00:00 [entrez] PHST- 1988/08/15 00:00 [pmc-release] AID - 10.1042/bj2500303 [doi] PST - ppublish SO - Biochem J. 1988 Feb 15;250(1):303-5. doi: 10.1042/bj2500303.