PMID- 31284013
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20200914
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 373
DP  - 2019 Nov 5
TI  - Cardiovascular and hidroelectrolytic changes in rats fed with high-fat diet.
PG  - 112075
LID - S0166-4328(19)30357-2 [pii]
LID - 10.1016/j.bbr.2019.112075 [doi]
AB  - Obesity activates the renin-angiotensin and sympathetic systems facilitating 
      hypertension and changes in the hydroelectrolytic balance. In the present study, 
      in rats fed with high-fat diet (HFD), we investigated daily water intake and 
      urinary excretion, prandial consumption of water and the changes in blood 
      pressure and water intake to intracerebroventricular (icv) angiotensin II (ANG 
      II). Male Holtzman rats (290-320 g) were fed with standard diet (SD, 11% calories 
      from fat) or HFD (45% calories from fat) for 6 weeks. Part of the animals 
      received a stainless steel cannula in the lateral ventricle (LV) at the 6th week 
      after the beginning of the diets and the experiments were performed at the 7th 
      week. The pressor effect, but not the dipsogenic response to acute icv injection 
      of ANG II, was potentiated in the HFD rats. Daily water intake and urinary volume 
      were reduced in rats fed with HFD with no significant changes in sodium 
      excretion. Prandial water consumption was also reduced in rats ingesting HFD, an 
      effect almost totally reverted blocking salivation with atropine. These results 
      show a potentiation of the pressor response to icv ANG II in HFD-fed rats, 
      without changing icv ANG II-induced water intake. In addition, prandial and daily 
      water intake and urinary volume were reduced in HFD-fed rats, without changing 
      sodium excretion. Salivation in rats ingesting HFD may play a role in the reduced 
      prandial and daily water intake.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Sa, Jessica Matheus
AU  - Sa JM
AD  - Department of Physiology and Pathology, School of Dentistry, UNESP - Sao Paulo 
      State University, Araraquara, SP, Brazil.
FAU - Barbosa, Rafaela Moreira
AU  - Barbosa RM
AD  - Department of Physiology and Pathology, School of Dentistry, UNESP - Sao Paulo 
      State University, Araraquara, SP, Brazil.
FAU - Menani, Jose V
AU  - Menani JV
AD  - Department of Physiology and Pathology, School of Dentistry, UNESP - Sao Paulo 
      State University, Araraquara, SP, Brazil.
FAU - De Luca, Laurival Antonio Jr
AU  - De Luca LA Jr
AD  - Department of Physiology and Pathology, School of Dentistry, UNESP - Sao Paulo 
      State University, Araraquara, SP, Brazil.
FAU - Colombari, Eduardo
AU  - Colombari E
AD  - Department of Physiology and Pathology, School of Dentistry, UNESP - Sao Paulo 
      State University, Araraquara, SP, Brazil.
FAU - Almeida Colombari, Debora Simoes
AU  - Almeida Colombari DS
AD  - Department of Physiology and Pathology, School of Dentistry, UNESP - Sao Paulo 
      State University, Araraquara, SP, Brazil. Electronic address: 
      debora.sa.colombari@unesp.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190705
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 11128-99-7 (Angiotensin II)
SB  - IM
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Diet, High-Fat/*adverse effects
MH  - Drinking/*drug effects
MH  - Eating/drug effects
MH  - Hypertension/physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Obesity/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Water-Electrolyte Balance/physiology
OTO - NOTNLM
OT  - Angiotensin II
OT  - Arterial pressure
OT  - Obesity
OT  - Renal excretion
OT  - Water intake
EDAT- 2019/07/10 06:00
MHDA- 2020/09/15 06:00
CRDT- 2019/07/09 06:00
PHST- 2019/03/07 00:00 [received]
PHST- 2019/06/14 00:00 [revised]
PHST- 2019/07/05 00:00 [accepted]
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2019/07/09 06:00 [entrez]
AID - S0166-4328(19)30357-2 [pii]
AID - 10.1016/j.bbr.2019.112075 [doi]
PST - ppublish
SO  - Behav Brain Res. 2019 Nov 5;373:112075. doi: 10.1016/j.bbr.2019.112075. Epub 2019 
      Jul 5.