PMID- 31284267
OWN - NLM
STAT- MEDLINE
DCOM- 20200506
LR  - 20200506
IS  - 1741-7899 (Electronic)
IS  - 1470-1626 (Linking)
VI  - 158
IP  - 3
DP  - 2019 Sep
TI  - Characterization of dendritic cell (DC)-10 in recurrent miscarriage and recurrent 
      implantation failure.
PG  - 247-255
LID - 10.1530/REP-19-0172 [doi]
AB  - During pregnancy, the maternal immune system must tolerate the persistence of 
      semi-allogeneic fetus in the maternal tissue. Inadequate recognition of fetal 
      antigens may lead to pregnancy complications, such as recurrent miscarriage (RM) 
      and recurrent implantation failure (RIF). Dendritic cells (DCs) are key 
      regulators of protective immune responses and the development and maintenance of 
      tolerance. Regarding that DCs are important in the establishment of immune 
      tolerance in human pregnancy, it would be important to study the microenvironment 
      in which DCs reside or are activated may affect their functions toward tolerance 
      rather than active immune response. IL-10 plays a critical role in the 
      maintenance of normal pregnancy, and the increased production of IL-10 is 
      associated with successful pregnancy. In this study, we provide an in-depth 
      comparison of the phenotype and cytokine production by DC-10 and other DC 
      subsets, such as iDC and mDC. CD14+ monocyte-derived DCs were differentiated in 
      the presence of IL-10 (DC-10) in vitro from ten normal fertile controls, six RM 
      women and seven RIF women, and characterized for relevant markers. DC-10 was 
      characterized by relatively low expression of costimulatory molecule CD86, as 
      well as MHC class II molecule HLA-DR, high expression of tolerance molecules 
      HLA-G, ILT2, ILT4 and immunosuppressive cytokine IL-10, but produced little or no 
      proinflammatory cytokines, such as TNF-alpha, IL-6 and IL-12p70. Our study provides a 
      better understanding of the phenotypical properties of DC-10, which may 
      participate in the complex orchestration that leads to maternal immune tolerance 
      and homeostatic environment in human pregnancy.
FAU - Liu, Su
AU  - Liu S
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Fertility 
      Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
FAU - Wei, Hongxia
AU  - Wei H
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Fertility 
      Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
FAU - Li, Yuye
AU  - Li Y
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Fertility 
      Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
FAU - Diao, Lianghui
AU  - Diao L
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Fertility 
      Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
FAU - Lian, Ruochun
AU  - Lian R
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Fertility 
      Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
FAU - Zhang, Xu
AU  - Zhang X
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Fertility 
      Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
FAU - Zeng, Yong
AU  - Zeng Y
AD  - Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, 
      Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Fertility 
      Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Reproduction
JT  - Reproduction (Cambridge, England)
JID - 100966036
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Abortion, Habitual/*immunology/metabolism
MH  - Adult
MH  - Cell Differentiation
MH  - Dendritic Cells/immunology/*metabolism
MH  - Embryo Implantation/*immunology
MH  - Female
MH  - Humans
MH  - Interleukin-10/*metabolism
MH  - Interleukin-6/metabolism
MH  - Pregnancy
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2019/07/10 06:00
MHDA- 2020/05/07 06:00
CRDT- 2019/07/09 06:00
PHST- 2019/04/11 00:00 [received]
PHST- 2019/07/08 00:00 [accepted]
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2020/05/07 06:00 [medline]
PHST- 2019/07/09 06:00 [entrez]
AID - REP-19-0172.R1 [pii]
AID - 10.1530/REP-19-0172 [doi]
PST - ppublish
SO  - Reproduction. 2019 Sep;158(3):247-255. doi: 10.1530/REP-19-0172.