PMID- 31284538
OWN - NLM
STAT- MEDLINE
DCOM- 20191212
LR  - 20200225
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 24
IP  - 13
DP  - 2019 Jul 5
TI  - The Modulatory Action of Vitamin D on the Renin-Angiotensin System and the 
      Determination of Hepatic Insulin Resistance.
LID - 10.3390/molecules24132479 [doi]
LID - 2479
AB  - Vitamin D deficiency or hypovitaminosis D is associated with increased risks of 
      insulin resistance, type 2 diabetes mellitus (T2DM) and its related non-alcoholic 
      fatty liver disease (NAFLD). Meanwhile, inappropriate over-activation of the 
      renin-angiotensin system (RAS) in the liver leads to the hepatic dysfunction and 
      increased risk of T2DM, such as abnormalities in lipid and glucose metabolism. 
      Our previous findings have shown that calcitriol, an active metabolite of vitamin 
      D, reduces hepatic triglyceride accumulation and glucose output in diabetic db/db 
      mice and human hepatocellular cell HepG2 cells under insulin-resistant 
      conditions. Notwithstanding the existence of this evidence, the protective action 
      of vitamin D in the modulation of overexpressed RAS-induced metabolic 
      abnormalities in the liver under insulin resistance remains to be elusive and 
      investigated. Herein, we have reported the potential interaction between vitamin 
      D and RAS; and its beneficial effects on the expression and function of the RAS 
      components in HepG2 cells and primary hepatocytes under insulin-resistance 
      states. Our study findings suggest that hormonal vitamin D (calcitriol) has 
      modulatory action on the inappropriate upregulation of the hepatic RAS under 
      insulin-resistant conditions. If confirmed, vitamin D supplementation might 
      provide a nutraceutical potential as a cost-effective approach for the management 
      of hepatic metabolic dysfunction as observed in T2DM and related NAFLD.
FAU - Leung, Po Sing
AU  - Leung PS
AUID- ORCID: 0000-0001-8074-3178
AD  - School of Biomedical Sciences, Faculty of Medicine, The Chinese University of 
      Hong Kong, Hong Kong, China. psleung@cuhk.edu.hk.
LA  - eng
GR  - CUHK14107415/Research Grants Council of Hong Kong/
PT  - Journal Article
DEP - 20190705
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 1406-16-2 (Vitamin D)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Diabetes Mellitus, Type 2/metabolism/pathology
MH  - Glucose/metabolism
MH  - Hep G2 Cells
MH  - Humans
MH  - Insulin Resistance
MH  - Lipid Metabolism/drug effects
MH  - Liver/drug effects
MH  - Renin-Angiotensin System/drug effects
MH  - Signal Transduction/drug effects
MH  - Vitamin D/*pharmacology
PMC - PMC6651371
OTO - NOTNLM
OT  - AT1 receptor calcitriol
OT  - HepG2 cells
OT  - liver
OT  - obesity
OT  - pancreas
OT  - type 2 diabetes
COIS- No conflict of interest reported.
EDAT- 2019/07/10 06:00
MHDA- 2019/12/18 06:00
PMCR- 2019/07/05
CRDT- 2019/07/10 06:00
PHST- 2019/04/18 00:00 [received]
PHST- 2019/07/02 00:00 [revised]
PHST- 2019/07/03 00:00 [accepted]
PHST- 2019/07/10 06:00 [entrez]
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/07/05 00:00 [pmc-release]
AID - molecules24132479 [pii]
AID - molecules-24-02479 [pii]
AID - 10.3390/molecules24132479 [doi]
PST - epublish
SO  - Molecules. 2019 Jul 5;24(13):2479. doi: 10.3390/molecules24132479.