PMID- 31286221
OWN - NLM
STAT- MEDLINE
DCOM- 20190918
LR  - 20190918
IS  - 1432-8798 (Electronic)
IS  - 0304-8608 (Linking)
VI  - 164
IP  - 10
DP  - 2019 Oct
TI  - NP protein and F protein of pigeon paramyxovirus type 1 are associated with its 
      low pathogenicity in chickens.
PG  - 2525-2530
LID - 10.1007/s00705-019-04339-1 [doi]
AB  - In this study, we investigated which structural proteins of pigeon paramyxovirus 
      type 1 (PPMV-1) are responsible for its low pathogenicity in chickens. The 
      results revealed that the pathogenicity of the virus is determined by multiple 
      genes. The NP protein and F protein were found to have the strongest individual 
      effect on virulence, and this effect further enhanced when the two proteins were 
      expressed in combination. Our study highlights the influence of the NP and F 
      proteins on the pathogenicity of PPMV-1 in chickens.
FAU - Song, Yang
AU  - Song Y
AD  - Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of 
      Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, 
      Haidian, Beijing, 100193, China.
FAU - Pei, Yu
AU  - Pei Y
AD  - Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of 
      Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, 
      Haidian, Beijing, 100193, China.
FAU - Bu, Yawen
AU  - Bu Y
AD  - Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of 
      Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, 
      Haidian, Beijing, 100193, China.
FAU - Jia, Wenfeng
AU  - Jia W
AD  - Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of 
      Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, 
      Haidian, Beijing, 100193, China.
FAU - Zhang, Guozhong
AU  - Zhang G
AD  - Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of 
      Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, 
      Haidian, Beijing, 100193, China. zhanggz@cau.edu.cn.
LA  - eng
GR  - BAIC04-2019/Beijing Agriculture Innovation Consortium of Poultry Research System/
PT  - Journal Article
DEP - 20190708
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
RN  - 0 (Nucleocapsid Proteins)
RN  - 0 (Viral Fusion Proteins)
RN  - 0 (Virulence Factors)
SB  - IM
MH  - Animals
MH  - Chickens
MH  - Columbidae
MH  - Newcastle Disease/pathology/*virology
MH  - Newcastle disease virus/*genetics/isolation & purification/*pathogenicity
MH  - Nucleocapsid Proteins/*genetics
MH  - Poultry Diseases/pathology/*virology
MH  - Viral Fusion Proteins/*genetics
MH  - Virulence
MH  - Virulence Factors/*genetics
EDAT- 2019/07/10 06:00
MHDA- 2019/09/19 06:00
CRDT- 2019/07/10 06:00
PHST- 2019/04/17 00:00 [received]
PHST- 2019/06/13 00:00 [accepted]
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2019/09/19 06:00 [medline]
PHST- 2019/07/10 06:00 [entrez]
AID - 10.1007/s00705-019-04339-1 [pii]
AID - 10.1007/s00705-019-04339-1 [doi]
PST - ppublish
SO  - Arch Virol. 2019 Oct;164(10):2525-2530. doi: 10.1007/s00705-019-04339-1. Epub 
      2019 Jul 8.