PMID- 31286392
OWN - NLM
STAT- MEDLINE
DCOM- 20200309
LR  - 20220125
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 46
IP  - 5
DP  - 2019 Oct
TI  - Probiotic supplementation attenuates hippocampus injury and spatial learning and 
      memory impairments in a cerebral hypoperfusion mouse model.
PG  - 4985-4995
LID - 10.1007/s11033-019-04949-7 [doi]
AB  - Probiotics are referred to species of living microscopic organisms may help 
      conserve the normal balance of the digestive system and/or manage diseases. A 
      number of autoimmune, psychiatric, cardiovascular and cerebrovascular disorders 
      may be associated with the imbalance of gut microbiota. This study examines the 
      effect of 21 days consumption of multistrain probiotics on hippocampus injury, 
      spatial and learning memory and some potential molecular mechanisms in a mouse 
      model with cerebral hypoperfusion. Cerebral hypoperfusion was established in the 
      mouse model by bilateral common carotid artery occlusion (BCCAO) for 20 min and 
      24 h reperfusion. Mixtures of several probiotic bacteria at concentrations of 
      10(7), 10(8) and 10(9) CFU/day were orally administrated for 3 weeks before the 
      BCCAO. Spatial and learning memory, histological damage and apoptosis were 
      assessed in the CA1, CA3 and dentate gyrus (DG) of the hippocampus 24 h after 
      ischemia. The malondialdehyde (MDA) content and brain-derived neurotrophic factor 
      (BDNF) level were measured by ELISA technique. Prophylactic of probiotic 
      considerably reduced the number of apoptotic cells and neuronal death in the CA1, 
      CA3 and DG of the hippocampus at all three concentrations (P < 0.001). In 
      addition, probiotics reduced spatial memory impairment and neurological 
      dysfunction only at the 10(9)-CFU/day (P < 0.01). Nonetheless, probiotics did not 
      change the levels of BDNF and MDA in the hippocampus (P > 0.05). According to the 
      findings, the daily prophylactic ingestion of probiotics reduced hippocampus 
      damage and prevented the spatial learning and memory deficit by suppressing 
      apoptosis in the mouse model with cerebral hypoperfusion. Probiotic 
      supplementation may be suggested as a useful preventive dietary strategy for 
      groups susceptible to cerebrovascular diseases.
FAU - Rahmati, Hamideh
AU  - Rahmati H
AD  - Research Center of Physiology, Semnan University of Medical Sciences, Semnan, 
      Iran.
FAU - Momenabadi, Shahein
AU  - Momenabadi S
AD  - Research Center of Physiology, Semnan University of Medical Sciences, Semnan, 
      Iran.
FAU - Vafaei, Abbas Ali
AU  - Vafaei AA
AD  - Research Center of Physiology, Semnan University of Medical Sciences, Semnan, 
      Iran.
AD  - Department of Physiology, School of Medicine, Semnan University of Medical 
      Sciences, Semnan, Iran.
FAU - Bandegi, Ahmad Reza
AU  - Bandegi AR
AD  - Department of Biochemistry, Faculty of Medicine, Semnan University of Medical 
      Sciences, Semnan, Iran.
FAU - Mazaheri, Zohreh
AU  - Mazaheri Z
AD  - Basic Medical Science Research, Histogenotech Company, Tehran, Iran.
FAU - Vakili, Abedin
AU  - Vakili A
AD  - Research Center of Physiology, Semnan University of Medical Sciences, Semnan, 
      Iran. Ab.vakili@yahoo.com.
AD  - Department of Physiology, School of Medicine, Semnan University of Medical 
      Sciences, Semnan, Iran. Ab.vakili@yahoo.com.
LA  - eng
GR  - 1306/Vice Chancellor for Research Centers of Semnan University of Medical 
      Sciences/
PT  - Journal Article
DEP - 20190708
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/pathology
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Carotid Artery Diseases/pathology
MH  - Dietary Supplements
MH  - Disease Models, Animal
MH  - Hippocampus/drug effects
MH  - Male
MH  - Malondialdehyde/analysis
MH  - Maze Learning/drug effects
MH  - Memory/drug effects
MH  - Memory Disorders/*metabolism
MH  - Mice
MH  - Probiotics/*pharmacology
MH  - Spatial Learning/*drug effects
OTO - NOTNLM
OT  - Apoptosis
OT  - BDNF
OT  - Cerebral hypoperfusion
OT  - Ischemia
OT  - Mice
OT  - Probiotic supplementation
OT  - Spatial memory
EDAT- 2019/07/10 06:00
MHDA- 2020/03/10 06:00
CRDT- 2019/07/10 06:00
PHST- 2019/03/26 00:00 [received]
PHST- 2019/06/27 00:00 [accepted]
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2020/03/10 06:00 [medline]
PHST- 2019/07/10 06:00 [entrez]
AID - 10.1007/s11033-019-04949-7 [pii]
AID - 10.1007/s11033-019-04949-7 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2019 Oct;46(5):4985-4995. doi: 10.1007/s11033-019-04949-7. Epub 
      2019 Jul 8.