PMID- 31287408
OWN - NLM
STAT- MEDLINE
DCOM- 20200403
LR  - 20220609
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 38
IP  - 2
DP  - 2020 Mar-Apr
TI  - Is periodontitis a prognostic factor in order to indicate antibodies against 
      citrullinated peptides in patients with rheumatoid arthritis?
PG  - 227-238
LID - 10.55563/clinexprheumatol/9p1bcm [doi]
AB  - OBJECTIVES: In this cross-sectional study we investigated antibody titres against 
      cyclic citrullinated peptides derived from filaggrin (anti-CCP) and citrullinated 
      alpha-enolase (anti-CEP-1) among patients with RA as a function of periodontal 
      findings. METHODS: 107 patients with RA (median age 56 years, 75% females) were 
      included. For periodontal diagnoses missing teeth, periodontal epithelial surface 
      area, periodontal inflamed surface area and periodontal diagnosis according to 
      the working group's guidelines of the Center for Disease Control and Prevention 
      were determined. Subgingival bacterial DNA of five periodontopathic bacteria was 
      assessed by PCR with sequence-specific oligonucleotides. Anti-CCP and anti-CEP-1 
      antibodies in plasma samples were investigated using enzyme-linked immunosorbent 
      assays. Low resolution human leukocyte antigen (HLA) typing was carried out using 
      PCR with sequence-specific primers. RESULTS: PESA was found associated with a low 
      adjusted odds ratio for anti-CCP positivity (OR=1.002, p=0.040). All patients who 
      were infected with Aggregatibacter actinomycetemcomitans were simultaneously 
      anti-CCP positive (p=0.043). HLA-DRB1*13 lowered the adjusted odds ratio for 
      anti-CCP (OR=0.073, p=0.002) and anti-CEP-1 (OR=0.068, p=0.018) positivity 
      whereas HLA-DRB1*07 indicated a lower risk only for demonstrable anti-CCP 
      antibodies (OR=0.079, p=0.004). HLA-DRB1*04 was associated with increased 
      adjusted odds ratio for anti-CEP-1 positivity (OR=4.154, p=0.005) and the 
      simultaneous proof of both investigated autoantibodies (OR=3.725, p=0.011). 
      CONCLUSIONS: Among patients with RA periodontitis may be a minor risk factor for 
      anti-CCP positivity. Our data first provide evidence that an infection with A. 
      actinomycetemcomitans is associated with an increased formation of anti-CCP. HLA 
      phenotype proved to be a significant risk indicator for both investigated 
      antibodies.
FAU - Reichert, Stefan
AU  - Reichert S
AD  - Department of Operative Dentistry and Periodontology, Martin-Luther University 
      Halle-Wittenberg, Germany. stefan.reichert@uk-halle.de.
FAU - Jurianz, Elisa
AU  - Jurianz E
AD  - Department of Operative Dentistry and Periodontology, Martin-Luther University 
      Halle-Wittenberg, Germany.
FAU - Natalie, Putz
AU  - Natalie P
AD  - Department of Operative Dentistry and Periodontology, Martin-Luther University 
      Halle-Wittenberg, Germany.
FAU - Schlumberger, Wolfgang
AU  - Schlumberger W
AD  - EUROIMMUN AG, Lubeck, Germany.
FAU - Dahnrich, Cornelia
AU  - Dahnrich C
AD  - EUROIMMUN AG, Lubeck, Germany.
FAU - Johannsen, Nora
AU  - Johannsen N
AD  - EUROIMMUN AG, Lubeck, Germany.
FAU - Altermann, Wolfgang
AU  - Altermann W
AD  - HLA Laboratory (GHATT), Martin-Luther University Halle-Wittenberg, Germany.
FAU - Schlaf, Gerald
AU  - Schlaf G
AD  - HLA Laboratory (GHATT), Martin-Luther University Halle-Wittenberg, Germany.
FAU - Keysser, Gernot
AU  - Keysser G
AD  - Clinic of Internal Medicine II, Martin-Luther University Halle-Wittenberg, 
      Germany.
FAU - Schaefer, Christoph
AU  - Schaefer C
AD  - Clinic of Internal Medicine II, Martin-Luther University Halle-Wittenberg, 
      Germany.
FAU - Schaller, Hans-Gunter
AU  - Schaller HG
AD  - Department of Operative Dentistry and Periodontology, Martin-Luther University 
      Halle-Wittenberg, Germany.
FAU - Schulz, Susanne
AU  - Schulz S
AD  - Department of Operative Dentistry and Periodontology, Martin-Luther University 
      Halle-Wittenberg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20190619
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Anti-Citrullinated Protein Antibodies)
RN  - 0 (Autoantibodies)
RN  - 0 (FLG protein, human)
RN  - 0 (Filaggrin Proteins)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Peptides, Cyclic)
SB  - IM
MH  - Anti-Citrullinated Protein Antibodies/metabolism
MH  - *Arthritis, Rheumatoid/epidemiology/immunology
MH  - Autoantibodies
MH  - Bacteroidaceae Infections/epidemiology/immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Filaggrin Proteins
MH  - *HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptides, Cyclic/*immunology
MH  - *Periodontitis/epidemiology/immunology/microbiology
MH  - Prognosis
MH  - Risk Factors
EDAT- 2019/07/10 06:00
MHDA- 2020/04/04 06:00
CRDT- 2019/07/10 06:00
PHST- 2019/01/18 00:00 [received]
PHST- 2019/05/05 00:00 [accepted]
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2020/04/04 06:00 [medline]
PHST- 2019/07/10 06:00 [entrez]
AID - 13892 [pii]
AID - 10.55563/clinexprheumatol/9p1bcm [doi]
PST - ppublish
SO  - Clin Exp Rheumatol. 2020 Mar-Apr;38(2):227-238. doi: 
      10.55563/clinexprheumatol/9p1bcm. Epub 2019 Jun 19.