PMID- 31288068
OWN - NLM
STAT- MEDLINE
DCOM- 20210104
LR  - 20210104
IS  - 1089-8646 (Electronic)
IS  - 0888-7543 (Linking)
VI  - 112
IP  - 2
DP  - 2020 Mar
TI  - A meta-analysis on genetic associations between Transcription Factor 7 Like 2 
      polymorphisms and type 2 diabetes mellitus.
PG  - 1192-1196
LID - S0888-7543(19)30368-4 [pii]
LID - 10.1016/j.ygeno.2019.07.004 [doi]
AB  - BACKGROUND: Some previous studies already explored associations of Transcription 
      Factor 7 Like 2 (TCF7L2) polymorphisms with type 2 diabetes mellitus (T2DM), with 
      conflicting findings. Here, we aimed to better analyze the relationship between 
      TCF7L2 polymorphisms and T2DM in a larger combined population by performing a 
      meta-analysis. METHODS: We searched Pubmed, Embase, Web of Science and CNKI for 
      related articles. We calculated odds ratio (OR) and 95% confidence interval (CI) 
      to estimate whether there are genetic associations between TCF7L2 polymorphisms 
      and T2DM. RESULTS: Totally 42 studies were included for this meta-analysis. The 
      meta-analysis results demonstrated that TCF7L2 rs4506565, rs7901695, rs11196205 
      and rs12255372 polymorphisms were all significantly associated with 
      susceptibility to T2DM in general population. Further subgroup analyses revealed 
      similar significant findings in both Asians and Caucasians. CONCLUSIONS: Our 
      findings supported that these TCF7L2 polymorphisms could be used to identify 
      individuals at high risk of developing T2DM.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Xi, Xin
AU  - Xi X
AD  - Central laboratory, Affiliated Hospital of Hebei University, Baoding 071000, 
      Hebei, China.
FAU - Ma, Jinhui
AU  - Ma J
AD  - Department of endocrinology, Affiliated Hospital of Hebei University, Baoding 
      071000, Hebei, China. Electronic address: majinhua587@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20190706
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Transcription Factor 7-Like 2 Protein/*genetics
OTO - NOTNLM
OT  - Asians
OT  - Caucasians
OT  - Meta-analysis
OT  - Polymorphisms
OT  - Transcription Factor 7 Like 2 (TCF7L2)
OT  - Type 2 diabetes mellitus (T2DM)
COIS- Declaration of Competing Interest The authors declare that they have no conflict 
      of interests.
EDAT- 2019/07/10 06:00
MHDA- 2021/01/05 06:00
CRDT- 2019/07/10 06:00
PHST- 2019/06/20 00:00 [received]
PHST- 2019/07/05 00:00 [accepted]
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2021/01/05 06:00 [medline]
PHST- 2019/07/10 06:00 [entrez]
AID - S0888-7543(19)30368-4 [pii]
AID - 10.1016/j.ygeno.2019.07.004 [doi]
PST - ppublish
SO  - Genomics. 2020 Mar;112(2):1192-1196. doi: 10.1016/j.ygeno.2019.07.004. Epub 2019 
      Jul 6.