PMID- 31288150
OWN - NLM
STAT- MEDLINE
DCOM- 20200303
LR  - 20200303
IS  - 1872-7506 (Electronic)
IS  - 0925-4927 (Linking)
VI  - 290
DP  - 2019 Aug 30
TI  - Network functional connectivity analysis in individuals at ultrahigh risk for 
      psychosis and patients with schizophrenia.
PG  - 51-57
LID - S0925-4927(18)30265-8 [pii]
LID - 10.1016/j.pscychresns.2019.06.004 [doi]
AB  - Schizophrenia is a severe mental disorder, and the onset of which is preceded by 
      a stage of ultrahigh risk (UHR) for developing psychosis. Therefore, analyzing 
      individuals with UHR is essential for identifying predictive biomarkers for the 
      onset of schizophrenia. The current study aimed to identify such biomarkers based 
      on a voxelwise whole-brain functional degree centrality (FDC) analysis. 
      Conjunction analysis showed that, compared with healthy controls, both UHR 
      subjects and patients with schizophrenia showed significantly increased FDC at 
      the medial prefrontal cortex (MPFC) and significantly decreased FDC at the right 
      fusiform gyrus (FG). The subsequent partial correlation analysis showed 
      significant correlations between the disorganization symptoms and FDCs at the 
      MPFC and the right FG for both UHR subjects and patients with schizophrenia. 
      These findings suggest that FDC within the MPFC and the right FG could be 
      candidate biomarkers for the onset of schizophrenia.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Chen, Xiongying
AU  - Chen X
AD  - The National Clinical Research Center for Mental Disorders & Beijing Key 
      Laboratory of Mental Disorders & the Advanced Innovation Center for Human Brain 
      Protection, Beijing Anding Hospital, School of Mental Health, Capital Medical 
      University, Beijing, China.
FAU - Li, Xianbin
AU  - Li X
AD  - The National Clinical Research Center for Mental Disorders & Beijing Key 
      Laboratory of Mental Disorders & the Advanced Innovation Center for Human Brain 
      Protection, Beijing Anding Hospital, School of Mental Health, Capital Medical 
      University, Beijing, China.
FAU - Yan, Tongjun
AU  - Yan T
AD  - The PLA 102(nd) Hospital and Mental Health Center of Military. Changzhou 213003, 
      PR China.
FAU - Dong, Qianhong
AU  - Dong Q
AD  - The National Clinical Research Center for Mental Disorders & Beijing Key 
      Laboratory of Mental Disorders & the Advanced Innovation Center for Human Brain 
      Protection, Beijing Anding Hospital, School of Mental Health, Capital Medical 
      University, Beijing, China.
FAU - Mao, Zhen
AU  - Mao Z
AD  - The National Clinical Research Center for Mental Disorders & Beijing Key 
      Laboratory of Mental Disorders & the Advanced Innovation Center for Human Brain 
      Protection, Beijing Anding Hospital, School of Mental Health, Capital Medical 
      University, Beijing, China.
FAU - Wang, Yanyan
AU  - Wang Y
AD  - The PLA 102(nd) Hospital and Mental Health Center of Military. Changzhou 213003, 
      PR China.
FAU - Yang, Ningbo
AU  - Yang N
AD  - The National Clinical Research Center for Mental Disorders & Beijing Key 
      Laboratory of Mental Disorders & the Advanced Innovation Center for Human Brain 
      Protection, Beijing Anding Hospital, School of Mental Health, Capital Medical 
      University, Beijing, China; First Affiliated Hospital of Henan University of 
      Science and Technology, No.24 Jinghua Road, Jianxi District, Luoyang 471003, 
      China.
FAU - Zhang, Qiumei
AU  - Zhang Q
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute for Brain Research, Beijing Normal University, China; School of Mental 
      Health, Jining Medical University, 45# Jianshe South Road, Jining 272013, 
      Shandong Province, PR China.
FAU - Zhao, Wan
AU  - Zhao W
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute for Brain Research, Beijing Normal University, China.
FAU - Zhai, Jinguo
AU  - Zhai J
AD  - School of Mental Health, Jining Medical University, 45# Jianshe South Road, 
      Jining 272013, Shandong Province, PR China.
FAU - Chen, Min
AU  - Chen M
AD  - School of Mental Health, Jining Medical University, 45# Jianshe South Road, 
      Jining 272013, Shandong Province, PR China.
FAU - Du, Boqi
AU  - Du B
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute for Brain Research, Beijing Normal University, China.
FAU - Deng, Xiaoxiang
AU  - Deng X
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute for Brain Research, Beijing Normal University, China.
FAU - Ji, Feng
AU  - Ji F
AD  - School of Mental Health, Jining Medical University, 45# Jianshe South Road, 
      Jining 272013, Shandong Province, PR China.
FAU - Xiang, Yu-Tao
AU  - Xiang YT
AD  - Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, 
      Macau, PR China.
FAU - Song, Jie
AU  - Song J
AD  - Shengli Hospital of Shengli Petroleum Administration Bureau, Dongying 257022, 
      Shandong province, PR China.
FAU - Wu, Hongjie
AU  - Wu H
AD  - Shengli Hospital of Shengli Petroleum Administration Bureau, Dongying 257022, 
      Shandong province, PR China.
FAU - Dong, Qi
AU  - Dong Q
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute for Brain Research, Beijing Normal University, China.
FAU - Chen, Chuansheng
AU  - Chen C
AD  - Department of Psychology and Social Behavior, University of California, Irvine, 
      CA 92697, United States.
FAU - Wang, Chuanyue
AU  - Wang C
AD  - The National Clinical Research Center for Mental Disorders & Beijing Key 
      Laboratory of Mental Disorders & the Advanced Innovation Center for Human Brain 
      Protection, Beijing Anding Hospital, School of Mental Health, Capital Medical 
      University, Beijing, China. Electronic address: wang_cy@ccmu.edu.cn.
FAU - Li, Jun
AU  - Li J
AD  - State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern 
      Institute for Brain Research, Beijing Normal University, China. Electronic 
      address: lijundp@bnu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190625
PL  - Netherlands
TA  - Psychiatry Res Neuroimaging
JT  - Psychiatry research. Neuroimaging
JID - 101723001
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Biomarkers/analysis
MH  - Brain/diagnostic imaging/physiopathology
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*diagnostic imaging
MH  - Prefrontal Cortex/diagnostic imaging/physiopathology
MH  - Psychotic Disorders/*diagnostic imaging/etiology
MH  - Risk Assessment/methods
MH  - Schizophrenia/*diagnostic imaging/etiology
MH  - Temporal Lobe/diagnostic imaging/physiopathology
OTO - NOTNLM
OT  - Degree centrality
OT  - Functional connectivity
OT  - Network
OT  - Schizophrenia
OT  - Ultrahigh risk
EDAT- 2019/07/10 06:00
MHDA- 2020/03/04 06:00
CRDT- 2019/07/10 06:00
PHST- 2018/09/19 00:00 [received]
PHST- 2019/06/19 00:00 [revised]
PHST- 2019/06/21 00:00 [accepted]
PHST- 2019/07/10 06:00 [pubmed]
PHST- 2020/03/04 06:00 [medline]
PHST- 2019/07/10 06:00 [entrez]
AID - S0925-4927(18)30265-8 [pii]
AID - 10.1016/j.pscychresns.2019.06.004 [doi]
PST - ppublish
SO  - Psychiatry Res Neuroimaging. 2019 Aug 30;290:51-57. doi: 
      10.1016/j.pscychresns.2019.06.004. Epub 2019 Jun 25.