PMID- 31288549 OWN - NLM STAT- MEDLINE DCOM- 20201208 LR - 20210402 IS - 1360-0451 (Electronic) IS - 0954-0121 (Print) IS - 0954-0121 (Linking) VI - 32 IP - 4 DP - 2020 Apr TI - Educational delays among children living with perinatally-acquired HIV in Johannesburg, South Africa. PG - 438-444 LID - 10.1080/09540121.2019.1640854 [doi] AB - Little is known about how growing up with HIV impacts educational outcomes in sub-Saharan African children. We evaluated if South African children living with HIV (CLWH) were in the appropriate school grade-for-age compared to uninfected control children. We observed higher rates of not being in the correct grade-for-age in CLWH compared with controls (OR 3.32, 95% CI: 2.07-5.34), adjusted for study site, sex, whether the child's biological father was alive, and caregiver education. Initiation of ART before 6 months of age reduced but did not eliminate this association. Whether these associations are due to biological factors or other social and environmental determinants, and how best to support CLWH to achieve educational goals, warrants further investigation. FAU - Shiau, Stephanie AU - Shiau S AD - G.H. Sergievsky Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, USA. AD - Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA. AD - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Arpadi, Stephen M AU - Arpadi SM AD - G.H. Sergievsky Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, USA. AD - Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA. AD - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. AD - ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York. AD - Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, USA. FAU - Burke, Megan AU - Burke M AD - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Liberty, Afaaf AU - Liberty A AD - Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa. FAU - Thurman, Cara AU - Thurman C AD - G.H. Sergievsky Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, USA. FAU - Patel, Faeezah AU - Patel F AD - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Strehlau, Renate AU - Strehlau R AD - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Abrams, Elaine J AU - Abrams EJ AD - Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA. AD - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. AD - ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York. AD - Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, USA. FAU - Coovadia, Ashraf AU - Coovadia A AD - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Violari, Avy AU - Violari A AD - Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa. FAU - Kuhn, Louise AU - Kuhn L AD - G.H. Sergievsky Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, USA. AD - Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA. AD - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. LA - eng GR - R01 HD073952/HD/NICHD NIH HHS/United States GR - R01 HD073977/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20190709 PL - England TA - AIDS Care JT - AIDS care JID - 8915313 RN - 0 (Anti-Retroviral Agents) SB - IM MH - Anti-Retroviral Agents/*therapeutic use MH - Case-Control Studies MH - Child MH - Disease Transmission, Infectious MH - Education MH - *Educational Status MH - Female MH - HIV Infections/complications/*drug therapy/epidemiology MH - Humans MH - Male MH - South Africa/epidemiology PMC - PMC6949430 MID - NIHMS1534525 OTO - NOTNLM OT - HIV OT - children OT - disclosure OT - education OT - pediatrics COIS- Disclosure of Interest Statement: The authors have no conflicts of interest to report. EDAT- 2019/07/11 06:00 MHDA- 2020/12/15 06:00 PMCR- 2021/04/01 CRDT- 2019/07/11 06:00 PHST- 2019/07/11 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] PHST- 2019/07/11 06:00 [entrez] PHST- 2021/04/01 00:00 [pmc-release] AID - 10.1080/09540121.2019.1640854 [doi] PST - ppublish SO - AIDS Care. 2020 Apr;32(4):438-444. doi: 10.1080/09540121.2019.1640854. Epub 2019 Jul 9.