PMID- 31289107 OWN - NLM STAT- MEDLINE DCOM- 20200305 LR - 20200309 IS - 2373-2822 (Electronic) IS - 2373-2822 (Linking) VI - 6 IP - 4 DP - 2019 Jul/Aug TI - Valence-Dependent Coupling of Prefrontal-Amygdala Effective Connectivity during Facial Affect Processing. LID - ENEURO.0079-19.2019 [pii] LID - 10.1523/ENEURO.0079-19.2019 [doi] AB - Despite the importance of the prefrontal-amygdala (AMY) network for emotion processing, valence-dependent coupling within this network remains elusive. In this study, we assessed the effect of emotional valence on brain activity and effective connectivity. We tested which functional pathways within the prefrontal-AMY network are specifically engaged during the processing of emotional valence. Thirty-three healthy adults were examined with functional magnetic resonance imaging while performing a dynamic faces and dynamic shapes matching task. The valence of the facial expressions varied systematically between positive, negative, and neutral across the task. Functional contrasts determined core areas of the emotion processing circuitry, comprising the medial prefrontal cortex (MPFC), the right lateral prefrontal cortex (LPFC), the AMY, and the right fusiform face area (FFA). Dynamic causal modelling demonstrated that the bidirectional coupling within the prefrontal-AMY circuitry is modulated by emotional valence. Additionally, Bayesian model averaging showed significant bottom-up connectivity from the AMY to the MPFC during negative and neutral, but not positive, valence. Thus, our study provides strong evidence for alterations of bottom-up coupling within the prefrontal-AMY network as a function of emotional valence. Thereby our results not only advance the understanding of the human prefrontal-AMY circuitry in varying valence context, but, moreover, provide a model to examine mechanisms of valence-sensitive emotional dysregulation in neuropsychiatric disorders. CI - Copyright (c) 2019 Willinger et al. FAU - Willinger, David AU - Willinger D AUID- ORCID: 0000-0002-3110-2355 AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8032, Switzerland. AD - Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich 8057, Switzerland. FAU - Karipidis, Iliana I AU - Karipidis II AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8032, Switzerland. AD - Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich 8057, Switzerland. AD - Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA 94305. FAU - Beltrani, Selina AU - Beltrani S AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8032, Switzerland. FAU - Di Pietro, Sarah V AU - Di Pietro SV AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8032, Switzerland. AD - Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich 8057, Switzerland. FAU - Sladky, Ronald AU - Sladky R AUID- ORCID: 0000-0002-5986-1572 AD - Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8008, Switzerland. AD - Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna 1010, Austria. FAU - Walitza, Susanne AU - Walitza S AUID- ORCID: 0000-0002-8161-8683 AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8032, Switzerland. AD - Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich 8057, Switzerland. FAU - Stampfli, Philipp AU - Stampfli P AUID- ORCID: 0000-0003-1684-2416 AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8032, Switzerland. AD - Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8008, Switzerland. FAU - Brem, Silvia AU - Brem S AUID- ORCID: 0000-0002-8031-1305 AD - Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8032, Switzerland silvia.brem@uzh.ch. AD - Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich 8057, Switzerland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190725 PL - United States TA - eNeuro JT - eNeuro JID - 101647362 SB - IM MH - Adult MH - Amygdala/*physiology MH - Bayes Theorem MH - Brain Mapping MH - Emotions/*physiology MH - Facial Expression MH - Facial Recognition/*physiology MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Neural Pathways/physiology MH - Prefrontal Cortex/*physiology MH - Young Adult PMC - PMC6658918 OTO - NOTNLM OT - DCM OT - amygdala OT - emotional valence OT - fMRI OT - prefrontal cortex EDAT- 2019/07/11 06:00 MHDA- 2020/03/07 06:00 PMCR- 2019/07/25 CRDT- 2019/07/11 06:00 PHST- 2019/03/06 00:00 [received] PHST- 2019/06/18 00:00 [revised] PHST- 2019/06/19 00:00 [accepted] PHST- 2019/07/11 06:00 [pubmed] PHST- 2020/03/07 06:00 [medline] PHST- 2019/07/11 06:00 [entrez] PHST- 2019/07/25 00:00 [pmc-release] AID - ENEURO.0079-19.2019 [pii] AID - eN-NWR-0079-19 [pii] AID - 10.1523/ENEURO.0079-19.2019 [doi] PST - epublish SO - eNeuro. 2019 Jul 25;6(4):ENEURO.0079-19.2019. doi: 10.1523/ENEURO.0079-19.2019. Print 2019 Jul/Aug.