PMID- 31289334
OWN - NLM
STAT- MEDLINE
DCOM- 20201130
LR  - 20210616
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Print)
IS  - 0307-0565 (Linking)
VI  - 44
IP  - 1
DP  - 2020 Jan
TI  - The effects of exercise session timing on weight loss and components of energy 
      balance: midwest exercise trial 2.
PG  - 114-124
LID - 10.1038/s41366-019-0409-x [doi]
AB  - BACKGROUND/OBJECTIVES: Circadian physiology has been linked to body weight 
      regulation and obesity. To date, few studies have assessed the association 
      between exercise timing and weight related outcomes. The aim of this secondary 
      analysis was to explore the impact of exercise timing (i.e., 24 h clock time of 
      exercise session) on weight loss and components of energy balance. 
      SUBJECTS/METHODS: Overweight/obese (BMI 25.0-39.9 kg/m(2)), physically inactive, 
      young adults (~51% female) completed a 10-month supervised exercise program (400 
      or 600 kcal/session for 5 days/week) or served as non-exercise controls (CON). 
      Participants were categorized based on the time of day in which they completed 
      exercise sessions (Early-Ex: >50% of sessions completed between 7:00 and 
      11:59 am; (n = 21), Late-Ex: >50% of sessions completed between 3:00 and 7:00 pm; 
      (n = 25), Sporadic-Ex: <50% of sessions completed in any time category; (n = 24), 
      and CON; (n = 18)). Body weight, energy intake (EI; digital photography), and 
      non-exercise physical activity (NEPA; accelerometer) were assessed at baseline, 
      3.5, 7, and 10 months. Total daily energy expenditure (TDEE; doubly labeled 
      water), was assessed at baseline and 10 months. RESULTS: At month 10, weight loss 
      was significantly greater in both Early-EX (-7.2 +/- 1.2%; p < 0.001) and 
      Sporadic-EX (- 5.5 +/- 1.2%; p = 0.01) vs CON (+0.5 +/- 1.0%), and Early-EX vs 
      Late-EX (-2.1 +/- 1.0%; p < 0.001). There were no between group differences for 
      change in TDEE, EI, and non-exercise energy expenditure (P > 0.05). A significant 
      group x time interaction (p = 0.02) was observed for NEPA (counts/min), however, 
      after adjusting for multiple comparisons, group effects were no longer 
      significant. CONCLUSIONS: Despite minimal differences in components of energy 
      balance, Early-EX lost significantly more weight compared with Late-Ex. Although 
      the mechanisms are unclear, the timing of exercise may be important for body 
      weight regulation.
FAU - Willis, Erik A
AU  - Willis EA
AD  - Center for Health Promotion and Disease Prevention, University of North 
      Carolina-Chapel Hill, Chapel Hill, NC, USA. erik.willis@unc.edu.
AD  - Division of Epidemiology and Genetics, Metabolic Epidemiology Branch, National 
      Cancer Institute, Bethesda, MD, USA. erik.willis@unc.edu.
FAU - Creasy, Seth A
AU  - Creasy SA
AUID- ORCID: 0000-0002-4176-0917
AD  - Division of Endocrinology, Metabolism, and Diabetes, Anschutz Medical Campus, 
      University of Colorado Aurora, Aurora, CO, USA.
FAU - Honas, Jeffery J
AU  - Honas JJ
AD  - Department of Internal Medicine, The University of Kansas Medical Center, Kansas 
      City, KS, USA.
FAU - Melanson, Edward L
AU  - Melanson EL
AD  - Division of Endocrinology, Metabolism, and Diabetes, Anschutz Medical Campus, 
      University of Colorado Aurora, Aurora, CO, USA.
AD  - Division of Geriatric Medicine, Department of Medicine, University of Colorado 
      Anschutz Medical Campus, Aurora, CO, USA.
AD  - Eastern Colorado VA Geriatric Research, Education, and Clinical Center, Denver, 
      CO, USA.
FAU - Donnelly, Joseph E
AU  - Donnelly JE
AD  - Department of Internal Medicine, The University of Kansas Medical Center, Kansas 
      City, KS, USA.
LA  - eng
GR  - K01 HL145023/HL/NHLBI NIH HHS/United States
GR  - P30 DK048520/DK/NIDDK NIH HHS/United States
GR  - R01 DK049181/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190709
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
SB  - IM
CIN - MMW Fortschr Med. 2020 Apr;162(8):26-27. PMID: 32342357
MH  - Adult
MH  - Circadian Clocks/*physiology
MH  - Energy Intake/physiology
MH  - Energy Metabolism/*physiology
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Obesity/physiopathology/therapy
MH  - Randomized Controlled Trials as Topic
MH  - Sedentary Behavior
MH  - Time Factors
MH  - Weight Loss/*physiology
MH  - Young Adult
PMC - PMC6925313
MID - NIHMS1528757
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/07/11 06:00
MHDA- 2020/12/01 06:00
PMCR- 2019/07/09
CRDT- 2019/07/11 06:00
PHST- 2018/10/17 00:00 [received]
PHST- 2019/05/01 00:00 [accepted]
PHST- 2019/04/17 00:00 [revised]
PHST- 2019/07/11 06:00 [pubmed]
PHST- 2020/12/01 06:00 [medline]
PHST- 2019/07/11 06:00 [entrez]
PHST- 2019/07/09 00:00 [pmc-release]
AID - 10.1038/s41366-019-0409-x [pii]
AID - 409 [pii]
AID - 10.1038/s41366-019-0409-x [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2020 Jan;44(1):114-124. doi: 10.1038/s41366-019-0409-x. Epub 
      2019 Jul 9.