PMID- 31289480
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 18
IP  - 1
DP  - 2019 Jul
TI  - Downregulated expression of human leukocyte antigen class I heavy chain is 
      associated with poor prognosis in non-small-cell lung cancer.
PG  - 117-126
LID - 10.3892/ol.2019.10293 [doi]
AB  - The aim of this study was to clarify the association between expression of human 
      leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and 
      patient survival. To address this, immunohistochemical staining for HLA class I 
      was performed on specimens from 111 patients with NSCLC, and overall survival 
      curves were compared using the log-rank test. In addition, multivariate analyses 
      were performed using Cox's proportional hazard model. The cases were divided into 
      5 classes based on the expression of HLA class I heavy chain and 
      beta2-microglobulin. The overall survival rate for patients with tumors lacking HLA 
      class I heavy chain (30 cases; 27.0%) was significantly decreased. The 
      multivariate analysis demonstrated that the absence of HLA class I heavy chain 
      was an independent predictor of poor prognosis. There was a trend towards an 
      unfavorable prognosis for patients whose tumors did not express beta2-microglobulin 
      (57 cases; 51.4%). Downregulation of HLA class I heavy chain expression was 
      significantly associated with the downregulation of beta2-microglobulin. Cases 
      lacking HLA class I heavy chain as well as beta2-microglobulin expression (23 cases; 
      20.7%) had a statistically significant unfavorable prognosis compared with other 
      cases. The present findings demonstrate that the lack of HLA class I heavy chain 
      expression in tumor cells is an independent prognostic factor for poor NSCLC 
      survival, and is likely to exert an important influence on immune surveillance in 
      patients.
FAU - Ichinokawa, Kazuomi
AU  - Ichinokawa K
AD  - Department of Gastroenterological Surgery II, Hokkaido University Graduate School 
      of Medicine, Sapporo, Hokkaido 060-8638, Japan.
FAU - Nakanishi, Yoshitsugu
AU  - Nakanishi Y
AD  - Department of Gastroenterological Surgery II, Hokkaido University Graduate School 
      of Medicine, Sapporo, Hokkaido 060-8638, Japan.
FAU - Hida, Yasuhiro
AU  - Hida Y
AD  - Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate 
      School of Medicine, Sapporo, Hokkaido 060-8638, Japan.
FAU - Tsuchikawa, Takahiro
AU  - Tsuchikawa T
AD  - Department of Gastroenterological Surgery II, Hokkaido University Graduate School 
      of Medicine, Sapporo, Hokkaido 060-8638, Japan.
FAU - Kato, Tatsuya
AU  - Kato T
AD  - Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate 
      School of Medicine, Sapporo, Hokkaido 060-8638, Japan.
FAU - Itoh, Tomoo
AU  - Itoh T
AD  - Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Hokkaido 
      060-8648, Japan.
FAU - Kaji, Mitsuhito
AU  - Kaji M
AD  - Department of Thoracic Surgery, Sapporo Minami Sanjo Hospital, Sapporo, Hokkaido 
      060-0063, Japan.
FAU - Kaga, Kichizo
AU  - Kaga K
AD  - Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate 
      School of Medicine, Sapporo, Hokkaido 060-8638, Japan.
FAU - Hirano, Satoshi
AU  - Hirano S
AD  - Department of Gastroenterological Surgery II, Hokkaido University Graduate School 
      of Medicine, Sapporo, Hokkaido 060-8638, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190430
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6540002
OTO - NOTNLM
OT  - human leukocyte antigen class I
OT  - immunohistochemistry
OT  - non-small-cell lung cancer
OT  - beta2-microglobulin antigen
EDAT- 2019/07/11 06:00
MHDA- 2019/07/11 06:01
PMCR- 2019/04/30
CRDT- 2019/07/11 06:00
PHST- 2016/06/13 00:00 [received]
PHST- 2019/03/01 00:00 [accepted]
PHST- 2019/07/11 06:00 [entrez]
PHST- 2019/07/11 06:00 [pubmed]
PHST- 2019/07/11 06:01 [medline]
PHST- 2019/04/30 00:00 [pmc-release]
AID - OL-0-0-10293 [pii]
AID - 10.3892/ol.2019.10293 [doi]
PST - ppublish
SO  - Oncol Lett. 2019 Jul;18(1):117-126. doi: 10.3892/ol.2019.10293. Epub 2019 Apr 30.