PMID- 31291740
OWN - NLM
STAT- MEDLINE
DCOM- 20191017
LR  - 20220410
IS  - 1943-572X (Electronic)
IS  - 0003-4894 (Linking)
VI  - 128
IP  - 11
DP  - 2019 Nov
TI  - Spindle Cell Lipomas of the Respiratory Tract: A Case Report and Comprehensive 
      Literature Review.
PG  - 1086-1091
LID - 10.1177/0003489419862577 [doi]
AB  - BACKGROUND: Spindle cell lipomas (SCLs) are benign tumors that are 
      characteristically present on the upper back and neck, but in rare cases present 
      throughout the respiratory mucosa, causing hoarseness, stridor, dyspnea, and 
      obstruction. OBJECTIVE: To highlight the importance of considering SCL in the 
      diagnosis of benign respiratory tract tumors, a literature review identified all 
      published cases of respiratory tract SCLs, including 2 from our institution: one 
      case in the nasopharynx and 1 in the nasal valve. METHODS: All case reports, 
      series and literature reviews from the English literature from 1975 through March 
      2018 were systematically identified for review in the MEDLINE, EMBASE, and Scopus 
      databases. Two additional cases from our institution were described. RESULTS: In 
      total, 24 cases of SCL in the respiratory tract were identified for review. Two 
      cases from our institution are described here, bringing the total of reported 
      cases to 26. Extensive analyses of oral cavity SCLs already exist, so we excluded 
      this site from our review and focused on sites where SCLs may present with 
      respiratory symptoms. Excluding the oral cavity and oropharynx, the most common 
      location described is the larynx. All 26 cases were treated with excision. One 
      tumor required a second surgery, but there were no other complications nor 
      recurrences. CONCLUSION: Although rare, SCLs may arise from throughout the 
      respiratory tract and cause dyspnea, hoarseness and stridor. Spindle cell lipoma 
      should be considered in the differential diagnosis of a respiratory tract mass. 
      This diagnosis confers a good prognosis and patients may be reassured that 
      surgery is almost always curative.
FAU - Reid, Jonathan
AU  - Reid J
AUID- ORCID: 0000-0003-1226-5834
AD  - Department of Otolaryngology-Head and Neck Surgery, Western University, London, 
      ON, Canada.
FAU - Wehrli, Bret
AU  - Wehrli B
AD  - Department of Pathology and Laboratory Medicine, Western University, London, ON, 
      Canada.
FAU - Sowerby, Leigh J
AU  - Sowerby LJ
AD  - Department of Otolaryngology-Head and Neck Surgery, Western University, London, 
      ON, Canada.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20190710
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
SB  - IM
MH  - Aged
MH  - Biopsy
MH  - Diagnosis, Differential
MH  - Dyspnea/*diagnosis/etiology
MH  - Humans
MH  - Lipoma/complications/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/complications/*diagnosis
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - case report
OT  - dyspnea
OT  - hoarseness
OT  - lipoma
OT  - nasal obstruction
OT  - respiratory mucosa
EDAT- 2019/07/12 06:00
MHDA- 2019/10/18 06:00
CRDT- 2019/07/12 06:00
PHST- 2019/07/12 06:00 [pubmed]
PHST- 2019/10/18 06:00 [medline]
PHST- 2019/07/12 06:00 [entrez]
AID - 10.1177/0003489419862577 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 2019 Nov;128(11):1086-1091. doi: 
      10.1177/0003489419862577. Epub 2019 Jul 10.