PMID- 31293816
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2164-2591 (Print)
IS  - 2164-2591 (Electronic)
IS  - 2164-2591 (Linking)
VI  - 8
IP  - 3
DP  - 2019 May
TI  - Fundus-Controlled Dark Adaptometry in Young Children Without and With 
      Spontaneously Regressed Retinopathy of Prematurity.
PG  - 62
LID - 10.1167/tvst.8.3.62 [doi]
LID - 62
AB  - PURPOSE: We correlate dark adaptation course with foveal morphologic alterations 
      in preterm and term-born children using a modified fundus-controlled perimeter 
      and spectral domain-optical coherence tomography (SD-OCT) imaging. METHODS: We 
      performed fundus-controlled chromatic dark adaptometry in premature children aged 
      6 to 13 years without retinopathy of prematurity (no-ROP; n = 61) and with 
      spontaneously regressed ROP (sr-ROP, n = 29), and in 11 age-matched term-born 
      children. The degree of macular developmental arrest (MDA), defined as a 
      disproportion of the outer nuclear layer to inner retinal layers in the fovea 
      (ONL+/IRL-ratio), was analyzed with the DiOCTA tool in SD-OCT scans. RESULTS: 
      Children with MDA showed a flatter dark adaptation course progression with a 
      significant rod-mediated sensitivity recovery delay (0.0113 vs. 0.0253 dB/s; P < 
      0.001). Preterm-born children with regular foveal morphology reached the final 
      rod-mediated dark-adapted threshold at 12 minutes after bleach at 18.8 dB, 
      compared to after 18.7 minutes at 17.6 dB in children with MDA (no significant 
      difference in final threshold; P = 0.773). The cone-mediated dark adaptation 
      progression showed a significant lower final threshold in children with MDA (6.0 
      vs. 8.1 dB; P = 0.004). CONCLUSIONS: Changes in dark adaptation were seen in the 
      presence of MDA observed in premature children in the no-ROP and sr-ROP groups. 
      MDA in former premature children is associated with functional deficits of cone 
      and rod photoreceptor visual pathways. TRANSLATIONAL RELEVANCE: Morphologic 
      alterations in the central retina of premature children, evident in SD-OCT, are 
      associated with long-term functional deficits in the rod and cone pathways, 
      particularly evident in the rod dark adaptation course measured at 12 degrees  
      eccentricity. This indicates a more widespread retinal functional pathology not 
      limited to the fovea, but occurring together with foveal alterations best defined 
      as MDA.
FAU - Bowl, Wadim
AU  - Bowl W
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Lorenz, Birgit
AU  - Lorenz B
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Stieger, Knut
AU  - Stieger K
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Schweinfurth, Silke
AU  - Schweinfurth S
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Holve, Kerstin
AU  - Holve K
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
FAU - Andrassi-Darida, Monika
AU  - Andrassi-Darida M
AD  - Department of Ophthalmology, Justus-Liebig-University, Giessen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20190628
PL  - United States
TA  - Transl Vis Sci Technol
JT  - Translational vision science & technology
JID - 101595919
PMC - PMC6602151
OTO - NOTNLM
OT  - dark adaptometry
OT  - macular developmental arrest MDA
OT  - optical coherence tomography
OT  - prematurity
OT  - retinopathy of prematurity
EDAT- 2019/07/12 06:00
MHDA- 2019/07/12 06:01
PMCR- 2019/06/28
CRDT- 2019/07/12 06:00
PHST- 2018/05/24 00:00 [received]
PHST- 2019/03/20 00:00 [accepted]
PHST- 2019/07/12 06:00 [entrez]
PHST- 2019/07/12 06:00 [pubmed]
PHST- 2019/07/12 06:01 [medline]
PHST- 2019/06/28 00:00 [pmc-release]
AID - TVST-18-0899 [pii]
AID - 10.1167/tvst.8.3.62 [doi]
PST - epublish
SO  - Transl Vis Sci Technol. 2019 Jun 28;8(3):62. doi: 10.1167/tvst.8.3.62. 
      eCollection 2019 May.