PMID- 31294343
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2508-7576 (Electronic)
IS  - 2508-6235 (Print)
IS  - 2508-6235 (Linking)
VI  - 28
IP  - 2
DP  - 2019 Jun
TI  - Association between Body Fat and Diabetic Peripheral Neuropathy in Middle-Aged 
      Adults with Type 2 Diabetes Mellitus: A Preliminary Report.
PG  - 112-117
LID - 10.7570/jomes.2019.28.2.112 [doi]
AB  - BACKGROUND: Previous epidemiologic studies showed that obesity increased the risk 
      of diabetic peripheral neuropathy (DPN). However, there is very limited data 
      about the impact of body fat measured by body composition analysis in DPN. 
      METHODS: Subjects with type 2 diabetes mellitus (T2DM) between 20 to 55 years old 
      were enrolled. DPN was diagnosed using the Michigan Neuropathy Screening 
      Instrument. Body composition was assessed by bio-impedance analysis, and the 
      association between body composition and DPN was investigated. RESULTS: Among 65 
      subjects, 44.6% were diagnosed with DPN. Subjects with DPN had higher body mass 
      index and waist circumference than subjects without DPN. Body composition data 
      showed that fat mass, fat percent, and visceral fat area were higher in subjects 
      with DPN than in subjects without DPN. Furthermore, the presence of DPN was 
      associated with waist circumference (odds ratio [OR], 1.151; 95% confidence 
      interval [CI], 1.055-1.256; P=0.002), visceral fat area (OR, 1.026; 95% CI, 
      1.005-1.048; P=0.015), and insulin resistance (OR, 1.673; 95% CI, 1.091-2.565; 
      P=0.018) after adjusting age, sex, diabetes duration, and smoking status. 
      CONCLUSION: Abdominal obesity was associated with DPN. Insulin resistance might 
      mediate obesity and DPN in middle aged subjects with T2DM.
FAU - Oh, Tae Jung
AU  - Oh TJ
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul; Department of Internal Medicine, Seoul National University Bundang 
      Hospital, Seongnam, Korea.
FAU - Lee, Jie-Eun
AU  - Lee JE
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul; Department of Internal Medicine, Seoul National University Bundang 
      Hospital, Seongnam, Korea.
FAU - Choi, Sung Hee
AU  - Choi SH
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul; Department of Internal Medicine, Seoul National University Bundang 
      Hospital, Seongnam, Korea.
FAU - Jang, Hak Chul
AU  - Jang HC
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul; Department of Internal Medicine, Seoul National University Bundang 
      Hospital, Seongnam, Korea.
LA  - eng
PT  - Journal Article
DEP - 20190630
PL  - Korea (South)
TA  - J Obes Metab Syndr
JT  - Journal of obesity & metabolic syndrome
JID - 101704724
PMC - PMC6604847
OTO - NOTNLM
OT  - Diabetic neuropathy
OT  - Insulin resistance
OT  - Obesity
OT  - Visceral fat
COIS- CONFLICTS OF INTEREST The authors declare no conflict of interest.
EDAT- 2019/07/12 06:00
MHDA- 2019/07/12 06:01
PMCR- 2019/06/01
CRDT- 2019/07/12 06:00
PHST- 2019/02/25 00:00 [received]
PHST- 2019/03/13 00:00 [revised]
PHST- 2019/05/13 00:00 [accepted]
PHST- 2019/07/12 06:00 [entrez]
PHST- 2019/07/12 06:00 [pubmed]
PHST- 2019/07/12 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - jomes-28-112 [pii]
AID - 10.7570/jomes.2019.28.2.112 [doi]
PST - ppublish
SO  - J Obes Metab Syndr. 2019 Jun;28(2):112-117. doi: 10.7570/jomes.2019.28.2.112. 
      Epub 2019 Jun 30.