PMID- 31295747
OWN - NLM
STAT- MEDLINE
DCOM- 20200528
LR  - 20200528
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 51
IP  - 9
DP  - 2019 Sep
TI  - Magnetic Resonance Imaging or Endoscopic Ultrasonography for Detection and 
      Surveillance of Pancreatic Neuroendocrine Neoplasms in Patients with Multiple 
      Endocrine Neoplasia Type 1?
PG  - 580-585
LID - 10.1055/a-0931-7005 [doi]
AB  - Our aim was to compare the clinical utility of Magnetic Resonance Imaging (MRI) 
      and Endoscopic Ultrasonography (EUS) in identifying Pancreatic Neurondocrine 
      Neoplasms (PanNENs) and monitoring size alterations in Multiple Endocrine 
      Neoplasia type 1 (MEN1) patients. Thirty-one MEN1 patients with PanNENs and 
      concurrent screening by EUS and abdominal MRI were included and 129 pancreatic 
      lesions were detected in total. MRI detected fewer lesions than EUS (n=73 vs. 
      110, p=0.006). MRI sensitivity and specificity compared to EUS at 20 and 10 mm 
      cut-offs of maximal lesion diameter were 96 and 88% (20 mm cut-off) and 90 and 
      82%(10 mm cut-off), respectively (concordance rates of 97 and 87% and Cohen's 
      kappa=0.912 and 0.718, respectively). Lesions<1 cm were more often detected with 
      EUS (p=0.025). Data from sequential concurrent imaging on lesion growth rate [n=7 
      (mean+/-SD: 2 mm/year+/-3.4 mm vs. 1.9 mm/year+/-3.6 mm)] over a period of at least two 
      years as well as pathology data in connection to preoperative concurrent imaging 
      were available in a small number of patients (n=7, p=0.933 for mean differences 
      in maximal lesion diameter). MRI of the pancreas was more readily available and 
      less expensive than EUS in an outpatient setting. In conclusion, MRI performs 
      well compared to EUS for the detection and subsequent surveillance of 
      MEN1-related panNENs larger than 10 mm and seems to be cost-effective. Both 
      modalities could be used at initial assessment and MRI alone could be utilized 
      thereafter in patient surveillance. EUS retains its value in surgical planning 
      and the detection of small mostly functional PanNENs.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Daskalakis, Kosmas
AU  - Daskalakis K
AD  - Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
AD  - 1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko 
      Hospital, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Tsoli, Marina
AU  - Tsoli M
AD  - 1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko 
      Hospital, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Alexandraki, Krystallenia I
AU  - Alexandraki KI
AD  - 1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko 
      Hospital, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Angelousi, Anna
AU  - Angelousi A
AD  - 1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko 
      Hospital, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Chatzellis, Eleftherios
AU  - Chatzellis E
AD  - 1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko 
      Hospital, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Tsolakis, Apostolos V
AU  - Tsolakis AV
AD  - Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.
AD  - Cancer Centre Karolinska, CCK, Karolinska University Hospital, Stockholm, Sweden.
FAU - Karoumpalis, Ioannis
AU  - Karoumpalis I
AD  - Department of Gastroenterology, "G. Gennimatas" General Hospital, Athens, Greece.
FAU - Kolomodi, Denise
AU  - Kolomodi D
AD  - 1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko 
      Hospital, National and Kapodistrian University of Athens, Athens, Greece.
FAU - Kassi, Evanthia
AU  - Kassi E
AD  - 1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko 
      Hospital, National and Kapodistrian University of Athens, Athens, Greece.
AD  - Department of Biological Chemistry, Medical School, National and Kapodistrian 
      niversity of Athens, Athens, Greece.
FAU - Kaltsas, Gregory
AU  - Kaltsas G
AD  - 1st Department of Propaupedic Internal Medicine, Endocrine Oncology Unit, Laiko 
      Hospital, National and Kapodistrian University of Athens, Athens, Greece.
AD  - Clinical Sciences Research Laboratories, Warwick Medical School, University of 
      Warwick, University Hospital, Coventry, UK.
AD  - Centre of Applied Biological & Exercise Sciences, Faculty of Health & Life 
      Sciences, Coventry University, Coventry, UK.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190711
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Endosonography/economics/*methods
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/economics/*methods
MH  - Male
MH  - Middle Aged
MH  - Neuroendocrine Tumors/diagnosis/*diagnostic imaging/pathology
MH  - Pancreas/diagnostic imaging/pathology
MH  - Pancreatic Neoplasms/diagnosis/*diagnostic imaging/pathology
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Young Adult
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/07/12 06:00
MHDA- 2020/05/29 06:00
CRDT- 2019/07/12 06:00
PHST- 2019/07/12 06:00 [pubmed]
PHST- 2020/05/29 06:00 [medline]
PHST- 2019/07/12 06:00 [entrez]
AID - 10.1055/a-0931-7005 [doi]
PST - ppublish
SO  - Horm Metab Res. 2019 Sep;51(9):580-585. doi: 10.1055/a-0931-7005. Epub 2019 Jul 
      11.