PMID- 31297262
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2067-0656 (Print)
IS  - 2069-4032 (Electronic)
VI  - 45
IP  - 1
DP  - 2019 Jan-Mar
TI  - The Link Between Bone Osteocalcin and Energy Metabolism in a Group of 
      Postmenopausal Women.
PG  - 47-51
LID - 10.12865/CHSJ.45.01.06 [doi]
AB  - There is a dual relationship between bone and tissues involved in energy 
      metabolism (fat tissue and beta-pancreatic cells). Thus, bone remodeling is an 
      energy consuming process, but osteocalcin, the main on-collagenic protein, 
      synthesized by osteoblas during bone formation exerts a number of biological 
      effects on beta-pancreatic and adipose cells. With this data, we wanted to see if 
      the presence of a chronic metabolic disorder such as type 2 diabetes mellitus 
      (T2DM) influence this complex dual relationship. For this, we conducted a 
      cross-sectional study to evaluate the relation between osteocalcin and energetic 
      metabolism in a group of 146 postmenopausal womens with and without T2DM at CI 
      Parhon National Institute of Endocrinology, Bucharest. Clinical, metabolic and 
      hormonal parameters were evaluated. For statistical analysis we used Student 
      t-test and the Spearman correlation (statistical significance: p <0.05). Results: 
      63 patients with T2DM (63.88+/-8.56 years) and 83 women in the control group 
      (60.21+/-8.77 years) were included. Diabetic women showed a lower level of serum 
      total osteocalcin (p<0.05) HDL-cholesterol (p=0.02), and 25-hydroxyvitamin D 
      (25(OH)D). The body mass index (BMI), glycemic metabolism parameters and 
      triglyceride levels (p<0.05) were higher in this group. We found correlations 
      between osteocalcin and metabolic elements: negative with BMI (r=-0.329, p<0.05), 
      glycated hemoglobin (HbA1c) (r=-0.398, p<0.05), and serum triglycerides 
      (r=-0.329, p<0.05) respectively positive with HDL-cholesterol (r=0.279, p=0.001) 
      for the entire group of patients. Conclusions: Our study indicated the presence 
      of significant correlations between serum osteocalcin and glycemic and lipid 
      metabolism parameters, independent of the presence of diabetes.
FAU - Dumitru, N
AU  - Dumitru N
AD  - C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Carsote, M
AU  - Carsote M
AD  - C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Cocolos, A
AU  - Cocolos A
AD  - C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Petrova, E
AU  - Petrova E
AD  - C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Olaru, M
AU  - Olaru M
AD  - C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.
FAU - Dumitrache, C
AU  - Dumitrache C
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
FAU - Ghemigian, A
AU  - Ghemigian A
AD  - C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
LA  - eng
PT  - Case Reports
DEP - 20190331
PL  - Romania
TA  - Curr Health Sci J
JT  - Current health sciences journal
JID - 101597164
PMC - PMC6592666
OTO - NOTNLM
OT  - Bone turnover
OT  - energy metabolism
OT  - insulin
OT  - osteoblast
OT  - osteocalcin
EDAT- 2019/07/13 06:00
MHDA- 2019/07/13 06:01
PMCR- 2019/01/01
CRDT- 2019/07/13 06:00
PHST- 2019/02/05 00:00 [received]
PHST- 2019/03/16 00:00 [accepted]
PHST- 2019/07/13 06:00 [entrez]
PHST- 2019/07/13 06:00 [pubmed]
PHST- 2019/07/13 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 2019.01.06 [pii]
AID - 10.12865/CHSJ.45.01.06 [doi]
PST - ppublish
SO  - Curr Health Sci J. 2019 Jan-Mar;45(1):47-51. doi: 10.12865/CHSJ.45.01.06. Epub 
      2019 Mar 31.