PMID- 31299618
OWN - NLM
STAT- MEDLINE
DCOM- 20200415
LR  - 20200415
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 176
DP  - 2019 Sep
TI  - Combustion and friction-derived nanoparticles and industrial-sourced 
      nanoparticles: The culprit of Alzheimer and Parkinson's diseases.
PG  - 108574
LID - S0013-9351(19)30371-8 [pii]
LID - 10.1016/j.envres.2019.108574 [doi]
AB  - Redox-active, strongly magnetic, combustion and friction-derived nanoparticles 
      (CFDNPs) are abundant in particulate matter air pollution. Urban children and 
      young adults with Alzheimer disease Continuum have higher numbers of brain CFDNPs 
      versus clean air controls. CFDNPs surface charge, dynamic magnetic 
      susceptibility, iron content and redox activity contribute to ROS generation, 
      neurovascular unit (NVU), mitochondria, and endoplasmic reticulum (ER) damage, 
      and are catalysts for protein misfolding, aggregation and fibrillation. CFDNPs 
      respond to external magnetic fields and are involved in cell damage by 
      agglomeration/clustering, magnetic rotation and/or hyperthermia. This review 
      focus in the interaction of CFDNPs, nanomedicine and industrial NPs with 
      biological systems and the impact of portals of entry, particle sizes, surface 
      charge, biomolecular corona, biodistribution, mitochondrial dysfunction, cellular 
      toxicity, anterograde and retrograde axonal transport, brain dysfunction and 
      pathology. NPs toxicity information come from researchers synthetizing particles 
      and improving their performance for drug delivery, drug targeting, magnetic 
      resonance imaging and heat mediators for cancer therapy. Critical information 
      includes how these NPs overcome all barriers, the NPs protein corona changes as 
      they cross the NVU and the complexity of NPs interaction with soluble proteins 
      and key organelles. Oxidative, ER and mitochondrial stress, and a faulty complex 
      protein quality control are at the core of Alzheimer and Parkinson's diseases and 
      NPs mechanisms of action and toxicity are strong candidates for early development 
      and progression of both fatal diseases. Nanoparticle exposure regardless of 
      sources carries a high risk for the developing brain homeostasis and ought to be 
      included in the AD and PD research framework.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Calderon-Garciduenas, Lilian
AU  - Calderon-Garciduenas L
AD  - The University of Montana, Missoula, MT, 59812, USA; Universidad Del Valle de 
      Mexico, 04850, Mexico City, Mexico. Electronic address: 
      lilian.calderon-garciduenas@umontana.edu.
FAU - Reynoso-Robles, Rafael
AU  - Reynoso-Robles R
AD  - Instituto Nacional de Pediatria, 04530, Mexico.
FAU - Gonzalez-Maciel, Angelica
AU  - Gonzalez-Maciel A
AD  - Instituto Nacional de Pediatria, 04530, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190705
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
SB  - IM
MH  - Alzheimer Disease/*epidemiology
MH  - Environmental Exposure/*statistics & numerical data
MH  - Friction
MH  - Humans
MH  - *Nanoparticles
MH  - Parkinson Disease/*epidemiology
MH  - Tissue Distribution
OTO - NOTNLM
OT  - Agglomeration
OT  - Air pollution
OT  - Alpha-synuclein
OT  - Alzheimer disease continuum in children and young adults
OT  - Brain magnetite/maghemite
OT  - Combustion and friction derived nanoparticles
OT  - Endothelial damage
OT  - External magnetic fields
OT  - Fibrillation
OT  - Misfolded proteins
OT  - Mitochondrial and endoplasmic reticulum stress
OT  - Nanoparticles
OT  - Neurovascular unit
OT  - Oxidative stress
OT  - Parkinson
OT  - Transition metals
EDAT- 2019/07/13 06:00
MHDA- 2020/04/16 06:00
CRDT- 2019/07/13 06:00
PHST- 2019/05/08 00:00 [received]
PHST- 2019/06/11 00:00 [revised]
PHST- 2019/07/02 00:00 [accepted]
PHST- 2019/07/13 06:00 [pubmed]
PHST- 2020/04/16 06:00 [medline]
PHST- 2019/07/13 06:00 [entrez]
AID - S0013-9351(19)30371-8 [pii]
AID - 10.1016/j.envres.2019.108574 [doi]
PST - ppublish
SO  - Environ Res. 2019 Sep;176:108574. doi: 10.1016/j.envres.2019.108574. Epub 2019 
      Jul 5.