PMID- 31302732
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20211013
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Print)
IS  - 0940-1334 (Linking)
VI  - 270
IP  - 7
DP  - 2020 Oct
TI  - Twin study shows association between monocyte chemoattractant protein-1 and 
      kynurenic acid in cerebrospinal fluid.
PG  - 933-938
LID - 10.1007/s00406-019-01042-9 [doi]
AB  - Preclinical studies indicate a link between the kynurenine pathway and monocyte 
      chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies 
      examining this further. We here perform a secondary analysis of kynurenine 
      metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from 
      schizophrenia, bipolar disorder or unaffected. We show an association between 
      MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a 
      less pronounced association between MCP-1 and tryptophan. No association was 
      detected between MCP-1 and quinolinic acid. Further studies on the mechanism 
      behind the putative relationship between KYNA and MCP-1 are needed.
FAU - Johansson, Viktoria
AU  - Johansson V
AUID- ORCID: 0000-0003-3775-7245
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO 
      Box 281, 171 77, Stockholm, Sweden. viktoria.johansson@ki.se.
AD  - Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska 
      Institutet and Stockholm Health Care Services, Stockholm County Council, Norra 
      Stationsgatan 69, 11364, Stockholm, Sweden. viktoria.johansson@ki.se.
FAU - Erhardt, Sophie
AU  - Erhardt S
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Engberg, Goran
AU  - Engberg G
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Kegel, Magdalena
AU  - Kegel M
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Bhat, Maria
AU  - Bhat M
AD  - Protein Diagnostics, Precision Medicine and Genomics, IMED Biotech Unit, 
      AstraZeneca, Gothenburg, Sweden.
FAU - Schwieler, Lilly
AU  - Schwieler L
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 
      Sweden.
FAU - Blennow, Kaj
AU  - Blennow K
AD  - Department of Psychiatry and Neurochemistry, Institute of Neuroscience and 
      Physiology, Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
AD  - Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, 
      Sweden.
FAU - Zetterberg, Henrik
AU  - Zetterberg H
AD  - Department of Psychiatry and Neurochemistry, Institute of Neuroscience and 
      Physiology, Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
AD  - Department of Neurodegenerative Disease, Institute of Neurology, University 
      College London, Queen Square, London, UK.
AD  - UK Dementia Research Institute, London, UK.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, New Haven, CT, USA.
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
FAU - Wetterberg, Lennart
AU  - Wetterberg L
AD  - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
FAU - Hultman, Christina M
AU  - Hultman CM
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO 
      Box 281, 171 77, Stockholm, Sweden.
AD  - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 
      USA.
FAU - Landen, Mikael
AU  - Landen M
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO 
      Box 281, 171 77, Stockholm, Sweden.
AD  - Department of Psychiatry and Neurochemistry, Institute of Neuroscience and 
      Physiology, Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
LA  - eng
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Twin Study
DEP - 20190713
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 8DUH1N11BX (Tryptophan)
RN  - F6F0HK1URN (Quinolinic Acid)
RN  - H030S2S85J (Kynurenic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bipolar Disorder/*cerebrospinal fluid
MH  - Chemokine CCL2/*cerebrospinal fluid
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Kynurenic Acid/*cerebrospinal fluid
MH  - Male
MH  - Middle Aged
MH  - Quinolinic Acid/cerebrospinal fluid
MH  - Schizophrenia/*cerebrospinal fluid
MH  - Sweden
MH  - Tryptophan/cerebrospinal fluid
PMC - PMC7474706
OTO - NOTNLM
OT  - Biomarker
OT  - Cerebrospinal fluid
OT  - Chemokine ligand 2
OT  - Kynurenic acid
OT  - Monocyte chemoattractant protein-1
OT  - Twin study
COIS- Dr. Tyrone D. Cannon is a consultant to Boehringer Ingelheim Pharmaceuticals, and 
      Lundbeck A/S. Dr. Maria Bhat and Magdalena Kegel are employed by AstraZeneca AB. 
      Dr. Kaj Blennow has served as a consultant or at advisory boards for Alector, 
      Alzheon, CogRx, Biogen, Lilly, Novartis and Roche Diagnostics. He is a co-founder 
      of Brain Biomarker Solutions in Gothenburg AB, a GU Venture-based platform 
      company at the University of Gothenburg, all unrelated to the work presented in 
      this paper.
EDAT- 2019/07/16 06:00
MHDA- 2021/06/29 06:00
PMCR- 2019/07/13
CRDT- 2019/07/15 06:00
PHST- 2019/04/10 00:00 [received]
PHST- 2019/07/03 00:00 [accepted]
PHST- 2019/07/16 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2019/07/15 06:00 [entrez]
PHST- 2019/07/13 00:00 [pmc-release]
AID - 10.1007/s00406-019-01042-9 [pii]
AID - 1042 [pii]
AID - 10.1007/s00406-019-01042-9 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2020 Oct;270(7):933-938. doi: 
      10.1007/s00406-019-01042-9. Epub 2019 Jul 13.