PMID- 31305887
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231212
IS  - 1554-6578 (Electronic)
IS  - 0022-3069 (Linking)
VI  - 78
IP  - 8
DP  - 2019 Aug 1
TI  - Plasma Neurofilament Light Chain Levels Are Associated With Cortical 
      Hypometabolism in Alzheimer Disease Signature Regions.
PG  - 709-716
LID - 10.1093/jnen/nlz054 [doi]
AB  - Neurofilament light chain (NFL) has been recently introduced as a biomarker of 
      early dementia. 18-Fluorodeoxyglucose positron emission tomography (18F-FDG-PET) 
      is a proxy for regional hypometabolism in Alzheimer disease (AD). Globally 
      normalized 18F-FDG-PET values and levels of NFL and tau were obtained from 149 
      patients with mild cognitive impairment (MCI) from the baseline cohort of the 
      Alzheimer's Disease Neuroimaging Initiative database. We adopted a stepwise 
      partial correlation model using plasma NFL, plasma tau, CSF NFL, and regional 
      cerebral metabolic rate of glucose (CMRGlc) as main variables, and age, sex, and 
      Alzheimer's Disease Rating Scale (ADAS) as covariates. Significant regions were 
      entered into a stepwise multiple regression analysis to investigate the 
      independent correlation of each biomarker to baseline regional CMRGlc and its 
      progression in patients with MCI. Higher baseline CSF NFL levels correlated with 
      hypometabolism in bilateral precuneal and posterior cingulate cortex. After 
      correction for age, sex, and ADAS score, plasma NFL levels correlated with 
      hypometabolism in bilateral parahippocampal and middle temporal gyri. Cortical 
      hypometabolism in bilateral parahippocampal gyri and right fusiform and middle 
      temporal gyri was independently predicted by higher baseline plasma NFL levels in 
      a multiple regression model. Plasma NFL promises to be an early biomarker of 
      cortical hypometabolism in MCI and for MCI progression to AD.
CI  - (c) 2019 American Association of Neuropathologists, Inc. All rights reserved.
FAU - Mayeli, Mahsa
AU  - Mayeli M
AD  - Neuropsychology Association, Students' Scientific Research Center.
FAU - Mirshahvalad, Seyed Mohammad
AU  - Mirshahvalad SM
AD  - Faculty of Medicine.
FAU - Aghamollaii, Vajiheh
AU  - Aghamollaii V
AD  - Faculty of Medicine.
FAU - Tafakhori, Abbas
AU  - Tafakhori A
AD  - Faculty of Medicine.
FAU - Abdolalizadeh, Amirhussein
AU  - Abdolalizadeh A
AD  - Students' Scientific Research Center.
FAU - Rahmani, Farzaneh
AU  - Rahmani F
AD  - Students' Scientific Research Center.
AD  - Tehran University of Medical Sciences; and Neuroimaging Network (NIN), Universal 
      Scientific Education and Research Network, Tehran, Iran.
CN  - Alzheimer's Disease Neuroimaging Initiative
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
SB  - IM
OTO - NOTNLM
OT  - Alzheimer disease
OT  - Neurofilament light chain
OT  - Positron emission tomography
OT  - Tau
EDAT- 2019/07/16 06:00
MHDA- 2019/07/16 06:01
CRDT- 2019/07/16 06:00
PHST- 2019/07/16 06:01 [medline]
PHST- 2019/07/16 06:00 [pubmed]
PHST- 2019/07/16 06:00 [entrez]
AID - 5532311 [pii]
AID - 10.1093/jnen/nlz054 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 2019 Aug 1;78(8):709-716. doi: 10.1093/jnen/nlz054.