PMID- 31306689
OWN - NLM
STAT- MEDLINE
DCOM- 20191213
LR  - 20191217
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 132
DP  - 2019 Oct
TI  - Myo-inositol in the protection from cadmium-induced toxicity in mice kidney: An 
      emerging nutraceutical challenge.
PG  - 110675
LID - S0278-6915(19)30464-8 [pii]
LID - 10.1016/j.fct.2019.110675 [doi]
AB  - Cadmium (Cd) induces functional and morphological changes in kidney. Therefore, 
      the effects of a natural nutraceutical antioxidant, myo-inositol (MI), were 
      evaluated in mice kidneys after Cd challenge. Twenty-eight C57 BL/6 J mice were 
      divided into these groups: 0.9% NaCl; MI (360 mg/kg/day); CdCl(2) (2 mg/kg/day) 
      plus vehicle; CdCl(2) (2 mg/kg/day) plus MI (360 mg/kg/day). After 14 days, 
      kidneys were processed for structural, biochemical and morphometric evaluation. 
      Treatment with CdCl(2) increased urea nitrogen and creatinine in serum and 
      augmented tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase 
      (iNOS) expression. Furthermore, monocyte chemoattractant protein-1 (MCP-1), 
      kidney injury molecule-1 (KIM-1) and myo-inositol oxygenase (MIOX) 
      immunoreactivity, and terminal deoxynucleotidyl transferase dUTP nick end 
      labeling (TUNEL) positive cells number were significantly higher than control and 
      MI groups. Glutathione (GSH) content and glutathione peroxidase (GPx) activity 
      were reduced and structural changes were evident. The treatment with MI 
      significantly lowered urea nitrogen and creatinine levels, TNF-alpha and iNOS 
      expression, MCP-1, KIM-1 and MIOX immunoreactivity and TUNEL positive cells 
      number, increased GSH content and GPx activity and preserved kidney morphology. A 
      protection of MI against Cd-induced damages in mice kidney was demonstrated, 
      suggesting a strong antioxidant role of this nutraceutical against environmental 
      Cd harmful effects on kidney lesions.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Pallio, Giovanni
AU  - Pallio G
AD  - Department of Clinical and Experimental Medicine, University of Messina, 98121, 
      Messina, Italy.
FAU - Micali, Antonio
AU  - Micali A
AD  - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, 
      University of Messina, 98121, Messina, Italy. Electronic address: 
      amicali@unime.it.
FAU - Benvenga, Salvatore
AU  - Benvenga S
AD  - Department of Clinical and Experimental Medicine, University of Messina, 98121, 
      Messina, Italy.
FAU - Antonelli, Alessandro
AU  - Antonelli A
AD  - Department of Clinical and Experimental Medicine, University of Pisa, 56126, 
      Pisa, Italy.
FAU - Marini, Herbert R
AU  - Marini HR
AD  - Department of Clinical and Experimental Medicine, University of Messina, 98121, 
      Messina, Italy.
FAU - Puzzolo, Domenico
AU  - Puzzolo D
AD  - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, 
      University of Messina, 98121, Messina, Italy.
FAU - Macaione, Vincenzo
AU  - Macaione V
AD  - Department of Clinical and Experimental Medicine, University of Messina, 98121, 
      Messina, Italy.
FAU - Trichilo, Vincenzo
AU  - Trichilo V
AD  - Department of Clinical and Experimental Medicine, University of Messina, 98121, 
      Messina, Italy.
FAU - Santoro, Giuseppe
AU  - Santoro G
AD  - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, 
      University of Messina, 98121, Messina, Italy.
FAU - Irrera, Natasha
AU  - Irrera N
AD  - Department of Clinical and Experimental Medicine, University of Messina, 98121, 
      Messina, Italy.
FAU - Squadrito, Francesco
AU  - Squadrito F
AD  - Department of Clinical and Experimental Medicine, University of Messina, 98121, 
      Messina, Italy.
FAU - Altavilla, Domenica
AU  - Altavilla D
AD  - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, 
      University of Messina, 98121, Messina, Italy.
FAU - Minutoli, Letteria
AU  - Minutoli L
AD  - Department of Clinical and Experimental Medicine, University of Messina, 98121, 
      Messina, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190712
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Antioxidants)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4L6452S749 (Inositol)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - GAN16C9B8O (Glutathione)
RN  - J6K4F9V3BA (Cadmium Chloride)
SB  - IM
MH  - Animals
MH  - Antioxidants/administration & dosage
MH  - Blood Urea Nitrogen
MH  - Cadmium Chloride/*toxicity
MH  - Creatinine/blood
MH  - *Dietary Supplements
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Inositol/*pharmacology
MH  - Kidney/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
OTO - NOTNLM
OT  - Cadmium
OT  - KIM-1
OT  - Kidney
OT  - MIOX
OT  - Myo-inositol
OT  - Nutraceutical
EDAT- 2019/07/16 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/07/16 06:00
PHST- 2019/04/30 00:00 [received]
PHST- 2019/06/21 00:00 [revised]
PHST- 2019/07/11 00:00 [accepted]
PHST- 2019/07/16 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/07/16 06:00 [entrez]
AID - S0278-6915(19)30464-8 [pii]
AID - 10.1016/j.fct.2019.110675 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2019 Oct;132:110675. doi: 10.1016/j.fct.2019.110675. Epub 2019 
      Jul 12.