PMID- 31307161
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200106
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 65
IP  - 7
DP  - 2019 Jul 1
TI  - Evaluation of the Diagnostic Efficacy of Monocyte Parameters and MCP-1 to 
      Distinguishing Active Tuberculosis from Latent Tuberculosis.
LID - 10.7754/Clin.Lab.2018.181115 [doi]
AB  - BACKGROUND: It is important to distinguish those with active Mycobacterium 
      tuberculosis infection (ATB) from latent tuberculosis infection (LTBI) for 
      monitoring and treating the disease. Monocytes play an important role and may 
      undergo morphological changes against active TB infection. The aim of this study 
      is to investigate the clinical usefulness of the monocyte morphometric parameters 
      and monocyte chemoattractant protein-1 (MCP-1) to distinguish active tuberculosis 
      (ATB) from latent tuberculosis infection (LTBI) and healthy controls (HC). 
      METHODS: Peripheral blood was collected from 97 ATB patients, 113 LTBI patients, 
      and 101 healthy controls. The monocyte morphometric parameters were obtained 
      using a UniCel Coulter DxH800 system. MCP-1 level was determined by enzyme-linked 
      immunosorbent assay method. Cutoff values were established based on receiver 
      operator characteristic (ROC) curve analysis. RESULTS: Mean monocyte volume with 
      its standard deviation, mean monocyte conductivity, and MCP-1 were significantly 
      increased in ATB compared with LTBI and HC. ROC curve analyses showed that 
      simultaneous measurements of mean monocyte volume with its standard deviation, 
      mean monocyte conductivity and MCP-1 achieved good sensitivity and specificity 
      (93.8% and 93.1%), which may be clinically useful. CONCLUSIONS: The findings 
      using monocyte morphometric parameters and MCP-1 to distinguish ATB from LTBI 
      with high sensitivity and specificity may be a potential parameter for clinical.
FAU - Sun, Tingting
AU  - Sun T
FAU - Wu, Bin
AU  - Wu B
FAU - Wang, Jing
AU  - Wang J
FAU - Yuan, Tao
AU  - Yuan T
FAU - Huang, Hengliu
AU  - Huang H
FAU - Xu, Dongsheng
AU  - Xu D
FAU - Shaoli
AU  - Shaoli
FAU - Deng
AU  - Deng
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/*blood
MH  - Diagnosis, Differential
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Latent Tuberculosis/blood/*diagnosis/microbiology
MH  - Male
MH  - Middle Aged
MH  - Monocytes/cytology/*metabolism
MH  - Mycobacterium tuberculosis/physiology
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Tuberculosis/blood/diagnosis/microbiology
EDAT- 2019/07/17 06:00
MHDA- 2020/01/07 06:00
CRDT- 2019/07/17 06:00
PHST- 2019/07/17 06:00 [entrez]
PHST- 2019/07/17 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
AID - 10.7754/Clin.Lab.2018.181115 [doi]
PST - ppublish
SO  - Clin Lab. 2019 Jul 1;65(7). doi: 10.7754/Clin.Lab.2018.181115.