PMID- 31307657
OWN - NLM
STAT- MEDLINE
DCOM- 20191125
LR  - 20191125
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 117
DP  - 2019 Aug
TI  - Cardiovascular magnetic resonance with parametric mapping in long-term 
      ultra-marathon runners.
PG  - 89-94
LID - S0720-048X(19)30205-0 [pii]
LID - 10.1016/j.ejrad.2019.06.001 [doi]
AB  - PURPOSE: There is a direct reverse dose-effect relationship between the amount of 
      physical activity and cardiovascular risk. It is unknown whether this is true for 
      extreme, persistent endurance training. The aim of the study was to assess 
      structural changes of the heart in long-time ultra-marathon runners with special 
      focus on myocardial fibrosis using parametric mapping. METHOD: We studied a group 
      of 30 healthy, male ultra-marathon runners (mean age 40.9 +/- 6.6 yrs, median 9 yrs 
      of running with frequent competitions) and 10 matched controls not engaged in any 
      regular activities. All of them underwent cardiovascular magnetic resonance (CMR) 
      with 3 T scanner including T1-mapping, late gadolinium enhancement (LGE) and 
      extracellular volume (ECV) quantification. RESULTS: Athletes demonstrated 
      significantly larger heart chambers and left ventricular (LV) mass. LV systolic 
      function was unchanged. 73.3% of athletes fulfilled volumetric criteria for 
      dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy. 
      Non-ischemic, small volume LGE was found in 8 athletes and in 1 control (27% vs. 
      10%, p = 0.40). It was localised at insertion points (5 athletes, 1 control) or 
      in the septum or infero-lateral wall (3 athletes). Athletes with insertion point 
      LGE had higher right ventricular end-diastolic volume index in comparison to 
      athletes without LGE (p = 0.04), which suggests its relation to volume overload. 
      There were no differences between athletes and non-athletes in terms of ECV 
      values (26.1% vs. 25%, p = 0.29). CONCLUSIONS: Ultra-marathon runner's hearts 
      demonstrate a high degree of structural remodelling, but there is no significant 
      increase in focal or diffuse myocardial fibrosis.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Malek, Lukasz A
AU  - Malek LA
AD  - Faculty of Rehabilitation, Jozef Pilsudski University of Physical Education in 
      Warsaw, Poland. Electronic address: lukasz.malek@awf.edu.pl.
FAU - Barczuk-Falecka, Marzena
AU  - Barczuk-Falecka M
AD  - Department of Pediatric Radiology, Medical University of Warsaw, Poland.
FAU - Werys, Konrad
AU  - Werys K
AD  - Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, 
      Headington, Oxford, United Kingdom.
FAU - Czajkowska, Anna
AU  - Czajkowska A
AD  - Faculty of Tourism and Recreation, Jozef Pilsudski University of Physical 
      Education in Warsaw, Poland.
FAU - Mroz, Anna
AU  - Mroz A
AD  - Faculty of Physical Education, Jozef Pilsudski University of Physical Education 
      in Warsaw, Poland.
FAU - Witek, Katarzyna
AU  - Witek K
AD  - Faculty of Physical Education, Jozef Pilsudski University of Physical Education 
      in Warsaw, Poland.
FAU - Burrage, Matthew
AU  - Burrage M
AD  - Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, 
      Headington, Oxford, United Kingdom.
FAU - Bakalarski, Wawrzyniec
AU  - Bakalarski W
AD  - Faculty of Physical Education, Jozef Pilsudski University of Physical Education 
      in Warsaw, Poland.
FAU - Nowicki, Dariusz
AU  - Nowicki D
AD  - Faculty of Tourism and Recreation, Jozef Pilsudski University of Physical 
      Education in Warsaw, Poland.
FAU - Roik, Danuta
AU  - Roik D
AD  - Department of Pediatric Radiology, Medical University of Warsaw, Poland.
FAU - Brzewski, Michal
AU  - Brzewski M
AD  - Department of Pediatric Radiology, Medical University of Warsaw, Poland.
LA  - eng
PT  - Journal Article
DEP - 20190603
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adult
MH  - *Athletes
MH  - Cardiac Output
MH  - Cardiac Volume
MH  - Health Surveys
MH  - Heart/anatomy & histology/diagnostic imaging/*physiology
MH  - Humans
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Running/*physiology
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - Adaptation
OT  - Fibrosis
OT  - Late gadolinium enhancement
OT  - Running
OT  - T1-mapping
OT  - T2-mapping
EDAT- 2019/07/17 06:00
MHDA- 2019/11/26 06:00
CRDT- 2019/07/17 06:00
PHST- 2019/01/10 00:00 [received]
PHST- 2019/05/28 00:00 [revised]
PHST- 2019/06/02 00:00 [accepted]
PHST- 2019/07/17 06:00 [entrez]
PHST- 2019/07/17 06:00 [pubmed]
PHST- 2019/11/26 06:00 [medline]
AID - S0720-048X(19)30205-0 [pii]
AID - 10.1016/j.ejrad.2019.06.001 [doi]
PST - ppublish
SO  - Eur J Radiol. 2019 Aug;117:89-94. doi: 10.1016/j.ejrad.2019.06.001. Epub 2019 Jun 
      3.