PMID- 31307828 OWN - NLM STAT- MEDLINE DCOM- 20200417 LR - 20200417 IS - 1549-4713 (Electronic) IS - 0161-6420 (Linking) VI - 127 IP - 1 DP - 2020 Jan TI - Quantitative Assessment of the Retina Using OCT and Associations with Cognitive Function. PG - 107-118 LID - S0161-6420(18)33382-7 [pii] LID - 10.1016/j.ophtha.2019.05.021 [doi] AB - PURPOSE: To determine the association of retinal thickness with cognitive function in Japanese persons. DESIGN: Cross-sectional, population-based survey. PARTICIPANTS: A total of 1293 Japanese persons aged 65 to 86 years who resided in the Saku area in the Japan Public Health Center-Based Prospective Study participated in the eye and mental health screening. METHODS: Participants underwent comprehensive ophthalmic assessment, including fundus photography, measurement of intraocular pressure, and determination of refraction status. We assessed the thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell-inner plexiform layer (GC-IPL), and ganglion cell complex (GCC, which includes the retinal nerve fiber layer and GC-IPL), and the full thickness in the macula and peripapillary retinal nerve fiber layer (ppRNFL) using spectral-domain (SD) OCT. Cognitive tests consisted of the Mini-Mental State Examination, Wechsler Memory Scale Revised logical memory I/II subtest, clock drawing test, and Clinical Dementia Rating Scale. These were used to designate the participants in the following 3 groups: Normal, those with mild cognitive impairment (MCI), and those with dementia. Multivariable logistic regression models were used to analyze associations between retinal thickness and cognitive function after adjusting potential confounding factors. MAIN OUTCOME MEASURES: Association of retinal thickness with cognitive function. RESULTS: Among the 1293 potential subjects, 114 were excluded for a diagnosis of depression, 64 were excluded for retinal disease, and 140 were excluded for scanning errors or suboptimal OCT images. The remaining 975 participants (mean age, 73.2 years) were included in this analysis. Significant differences were found in the 3 groups in all layers and GCC thickness, but not in ppRNFL thickness. After adjusting for age, sex, educational status, and refraction, full macular thickness and GCC thickness were inversely associated with the presence of dementia, but ppRNFL thickness was not. Furthermore, GC-IPL, GCC, and full macular thicknesses were all associated with the presence of dementia in the inferior sectors. CONCLUSIONS: Macular thickness was associated with the presence of dementia, but ppRNFL was not. Our results suggest that OCT measurements of the macula could be superior to those of the ppRNFL in assessing neurodegenerative changes and a potentially useful diagnostic biomarker of cognitive function. CI - Copyright (c) 2019 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. FAU - Ito, Yoshikazu AU - Ito Y AD - Department of Ophthalmology, Keio University, Tokyo, Japan. FAU - Sasaki, Mariko AU - Sasaki M AD - Department of Ophthalmology, Keio University, Tokyo, Japan; Department of Ophthalmology, Tachikawa Hospital, Tokyo, Japan; Department of Ophthalmology, Tokyo Medical Center, Tokyo, Japan. Electronic address: mariko.sasaki@a2.keio.jp. FAU - Takahashi, Hiroki AU - Takahashi H AD - Department of Ophthalmology, Keio University, Tokyo, Japan; Department of Ophthalmology, Tachikawa Hospital, Tokyo, Japan. FAU - Nozaki, Shoko AU - Nozaki S AD - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan. FAU - Matsuguma, Shinichiro AU - Matsuguma S AD - Department of Ophthalmology, Keio University, Tokyo, Japan. FAU - Motomura, Kaoru AU - Motomura K AD - Department of Ophthalmology, Keio University, Tokyo, Japan. FAU - Ui, Rihito AU - Ui R AD - Department of Ophthalmology, Keio University, Tokyo, Japan; Department of Ophthalmology, Tachikawa Hospital, Tokyo, Japan. FAU - Shikimoto, Ryo AU - Shikimoto R AD - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan. FAU - Kawasaki, Ryo AU - Kawasaki R AD - Department of Vision Informatics (Topcon), Osaka University Graduate School of Medicine, Osaka, Japan. FAU - Yuki, Kenya AU - Yuki K AD - Department of Ophthalmology, Keio University, Tokyo, Japan. FAU - Sawada, Norie AU - Sawada N AD - Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan. FAU - Mimura, Masaru AU - Mimura M AD - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan. FAU - Tsubota, Kazuo AU - Tsubota K AD - Department of Ophthalmology, Keio University, Tokyo, Japan. FAU - Tsugane, Shoichiro AU - Tsugane S AD - Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190604 PL - United States TA - Ophthalmology JT - Ophthalmology JID - 7802443 SB - IM CIN - Ophthalmology. 2020 Jan;127(1):119-121. PMID: 31864471 MH - Aged MH - Cognition MH - Cognitive Dysfunction/*diagnosis/physiopathology MH - Cross-Sectional Studies MH - Dementia/*diagnosis/physiopathology MH - Female MH - Humans MH - Male MH - Nerve Fibers/*pathology MH - Organ Size MH - Prospective Studies MH - Retinal Diseases/*diagnosis/physiopathology MH - Retinal Ganglion Cells/*pathology MH - Tomography, Optical Coherence/methods EDAT- 2019/07/17 06:00 MHDA- 2020/04/18 06:00 CRDT- 2019/07/17 06:00 PHST- 2019/01/22 00:00 [received] PHST- 2019/04/26 00:00 [revised] PHST- 2019/05/10 00:00 [accepted] PHST- 2019/07/17 06:00 [pubmed] PHST- 2020/04/18 06:00 [medline] PHST- 2019/07/17 06:00 [entrez] AID - S0161-6420(18)33382-7 [pii] AID - 10.1016/j.ophtha.2019.05.021 [doi] PST - ppublish SO - Ophthalmology. 2020 Jan;127(1):107-118. doi: 10.1016/j.ophtha.2019.05.021. Epub 2019 Jun 4.