PMID- 31308153
OWN - NLM
STAT- MEDLINE
DCOM- 20200818
LR  - 20200818
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 7
DP  - 2019 Jul 31
TI  - Honeysuckle extract relieves ovalbumin-induced allergic rhinitis by inhibiting 
      AR-induced inflammation and autoimmunity.
LID - BSR20190673 [pii]
LID - 10.1042/BSR20190673 [doi]
AB  - Honeysuckle has antiviral, antioxidative and anti-inflammatory properties. 
      Allergic rhinitis (AR) is induced by immunoglobulin E (IgE)-mediated inflammatory 
      reaction. Our study investigates whether honeysuckle extract (HE) has therapeutic 
      effect on AR. An AR model of mice was established by ovalbumin (OVA). 
      Hematoxylin-Eosin staining was used to assess nasal mucosa damage. Enzyme-linked 
      immunosorbent assay (ELISA) was performed to determine serum histamine, IgE and 
      interleukin (IL)-2, IL-4, IL-17 and interferon-gamma (IFN-gamma) from nasal lavage fluid. 
      Western blot was carried out to analyze the protein level from nasal mucosa 
      tissue. We found that HE not only decreased nasal rubbing and sneezing in AR 
      mice, but also reduced AR-induced damage to nasal mucosa. Moreover, HE lowered 
      the levels of serum IgE and histamine and inhibited IL-4 and IL-17 levels from AR 
      mice but raised IL-2 and IFN-gamma levels in AR-induced nasal lavage fluid. Our 
      results also showed that HE elevated the protein levels of forkhead box P3 
      (Foxp3) and T-box transcription factor (T-bet) in AR-induced nasal mucosa tissue, 
      whereas it inhibited signal transducer and activator of transcription (STAT) 3 
      and GATA binding protein 3 (GATA-3) protein levels. By regulating AR-induced 
      inflammatory reaction and autoimmune response, HE also relieved OVA-induced AR. 
      Thus, HE could be used as a potential drug to treat AR.
CI  - (c) 2019 The Author(s).
FAU - Lin, Bin
AU  - Lin B
AUID- ORCID: 0000-0003-0301-9420
AD  - ENT Department, Guangzhou Hospital of Integrated Traditional and West Medicine, 
      No. 87 Yingbin Road, Huadu District, Guangzhou 510800, Guangdong Province, China 
      binl_linbin@163.com.
FAU - Cai, Bijuan
AU  - Cai B
AD  - ENT Department, Guangzhou Hospital of Integrated Traditional and West Medicine, 
      No. 87 Yingbin Road, Huadu District, Guangzhou 510800, Guangdong Province, China.
FAU - Wang, Huige
AU  - Wang H
AD  - ENT Department, The First Affiliated Hospital of Shantou University Medical 
      College, Shantou, China.
LA  - eng
PT  - Journal Article
DEP - 20190729
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Autoimmunity/*drug effects
MH  - Cytokines/immunology
MH  - Inflammation/drug therapy/immunology/pathology
MH  - Lonicera/*chemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nasal Mucosa/immunology/pathology
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Rhinitis, Allergic/*drug therapy/immunology/pathology
PMC - PMC6663992
OTO - NOTNLM
OT  - Allergic rhinitis (AR)
OT  - Autoimmunity
OT  - Honeysuckle extract (HE)
OT  - Inflammation
COIS- Animal experimental operations of our study were performed in accordance with 
      guide for Animal Care and Use of Guangzhou Hospital of Integrated Traditional and 
      Western Medicine. Animal experiment was accepted by ethics committees and health 
      authorities of Guangzhou Hospital of Integrated Traditional and Western Medicine. 
      The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2019/07/17 06:00
MHDA- 2020/08/19 06:00
PMCR- 2019/07/29
CRDT- 2019/07/17 06:00
PHST- 2019/03/22 00:00 [received]
PHST- 2019/06/13 00:00 [revised]
PHST- 2019/06/20 00:00 [accepted]
PHST- 2019/07/17 06:00 [pubmed]
PHST- 2020/08/19 06:00 [medline]
PHST- 2019/07/17 06:00 [entrez]
PHST- 2019/07/29 00:00 [pmc-release]
AID - BSR20190673 [pii]
AID - 10.1042/BSR20190673 [doi]
PST - epublish
SO  - Biosci Rep. 2019 Jul 29;39(7):BSR20190673. doi: 10.1042/BSR20190673. Print 2019 
      Jul 31.