PMID- 31308343
OWN - NLM
STAT- MEDLINE
DCOM- 20191101
LR  - 20200225
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 58
IP  - 14
DP  - 2019
TI  - Anti-Jo-1 Antibody-positive Interstitial Pneumonia in an Elderly Patient with 
      Congenital Rubella Syndrome.
PG  - 2063-2066
LID - 10.2169/internalmedicine.2454-18 [doi]
AB  - A 71-year-old woman with congenital rubella syndrome (CRS) presented with 
      prolonged cough. No physical findings suggested the presence of any connective 
      tissue diseases. Chest computed tomography showed ground-glass opacities and 
      consolidations in the bilateral lower lobes. She had elevated serum Krebs von den 
      Lungen-6, hypoxemia and positive serum anti-Jo-1 antibody. Bronchoalveolar lavage 
      fluid revealed lymphocytosis with a decreased CD4/CD8 ratio. A transbronchial 
      lung biopsy specimen revealed organizing pneumonia. Based on a diagnosis of 
      interstitial pneumonia with autoimmune features (IPAF), systemic corticosteroids 
      were administered, and a good outcome was obtained. A possible relationship 
      between CRS and IPAF is herein discussed.
FAU - Nozue, Tsuyoshi
AU  - Nozue T
AD  - Department of Respiratory Medicine, Hamamatsu Rosai Hospital, Japan.
FAU - Toyoshima, Mikio
AU  - Toyoshima M
AD  - Department of Respiratory Medicine, Hamamatsu Rosai Hospital, Japan.
FAU - Fukada, Atsuki
AU  - Fukada A
AD  - Department of Respiratory Medicine, Hamamatsu Rosai Hospital, Japan.
FAU - Suda, Takafumi
AU  - Suda T
AD  - Second Department of Internal Medicine, Hamamatsu University School of Medicine, 
      Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20190715
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Jo-1 antibody)
SB  - IM
MH  - Aged
MH  - Antibodies, Antinuclear/immunology
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - Cough
MH  - Female
MH  - Humans
MH  - Lung/pathology
MH  - Lung Diseases, Interstitial/*complications/*diagnosis/immunology
MH  - Rubella Syndrome, Congenital/*complications
MH  - Tomography, X-Ray Computed
PMC - PMC6701999
OTO - NOTNLM
OT  - autoimmunity
OT  - congenital rubella syndrome
OT  - interstitial pneumonia
COIS- The authors state that they have no Conflict of Interest (COI).
EDAT- 2019/07/17 06:00
MHDA- 2019/11/02 06:00
PMCR- 2019/07/15
CRDT- 2019/07/17 06:00
PHST- 2019/07/17 06:00 [entrez]
PHST- 2019/07/17 06:00 [pubmed]
PHST- 2019/11/02 06:00 [medline]
PHST- 2019/07/15 00:00 [pmc-release]
AID - 10.2169/internalmedicine.2454-18 [doi]
PST - ppublish
SO  - Intern Med. 2019;58(14):2063-2066. doi: 10.2169/internalmedicine.2454-18. Epub 
      2019 Jul 15.