PMID- 31309889
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20200914
IS  - 1873-5592 (Electronic)
IS  - 1389-4501 (Linking)
VI  - 20
IP  - 15
DP  - 2019
TI  - Engineering of Exosomes: Steps Towards Green Production of Drug Delivery System.
PG  - 1537-1549
LID - 10.2174/1389450120666190715104100 [doi]
AB  - Targeting of therapeutic agents to their specific site of action not only 
      increases the treatment efficacy, but also reduces systemic toxicity. Therefore, 
      various drug delivery systems (DDSs) have been developed to achieve this target. 
      However, most of those DDSs have several issues regarding biocompatibility and 
      environmental hazard. In contrast to the synthetic DDSs, exosome-based natural 
      carriers are biocompatible, biodegradable and safe for the environment. Since 
      exosomes play a role in intercellular communication, they have been widely 
      utilized as carriers for different therapeutic agents. This article was aimed to 
      provide an overview of exosomes as an environment-friendly DDS in terms of 
      engineering, isolation, characterization, application and limitation.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Sherif, Abdelrahman Y
AU  - Sherif AY
AD  - Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud 
      University, Riyadh, Saudi Arabia.
AD  - Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Harisa, Gamaleldin I
AU  - Harisa GI
AD  - Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud 
      University, Riyadh, Saudi Arabia.
AD  - Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 
      Saudi Arabia.
AD  - Department of Biochemistry, College of Pharmacy, Al-Azhar University, Nasr City, 
      Cairo, Egypt.
FAU - Alanazi, Fars K
AU  - Alanazi FK
AD  - Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud 
      University, Riyadh, Saudi Arabia.
AD  - Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Youssof, Abdullah M E
AU  - Youssof AME
AD  - Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud 
      University, Riyadh, Saudi Arabia.
AD  - Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 
      Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Targets
JT  - Current drug targets
JID - 100960531
SB  - IM
MH  - Bioengineering/*methods
MH  - *Drug Delivery Systems
MH  - *Exosomes
OTO - NOTNLM
OT  - Drug targeting
OT  - biological DDS
OT  - bionanocarrier
OT  - exosome
OT  - green DDS
OT  - vesicular carrier.
EDAT- 2019/07/17 06:00
MHDA- 2020/09/15 06:00
CRDT- 2019/07/17 06:00
PHST- 2019/04/22 00:00 [received]
PHST- 2019/06/09 00:00 [revised]
PHST- 2019/06/18 00:00 [accepted]
PHST- 2019/07/17 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2019/07/17 06:00 [entrez]
AID - CDT-EPUB-99612 [pii]
AID - 10.2174/1389450120666190715104100 [doi]
PST - ppublish
SO  - Curr Drug Targets. 2019;20(15):1537-1549. doi: 10.2174/1389450120666190715104100.