PMID- 31310173
OWN - NLM
STAT- MEDLINE
DCOM- 20200311
LR  - 20200311
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 292
IP  - 3
DP  - 2019 Sep
TI  - Left Atrial Fibrosis Assessed with Cardiac MRI in Patients with Paroxysmal and 
      Those with Persistent Atrial Fibrillation.
PG  - 575-582
LID - 10.1148/radiol.2019182629 [doi]
AB  - Background Electrophysiology studies have demonstrated that left atrial late 
      gadolinium enhancement (LGE) is associated with the chronicity of atrial 
      fibrillation (AF). To date, cardiac MRI has been used to assess the extent of 
      atrial LGE but not the distribution pattern of LGE in the left atrium. Purpose To 
      determine whether the MRI pattern of left atrial fibrosis is associated with the 
      chronicity of AF. Materials and Methods This retrospective study included 
      patients with AF who underwent LGE MRI between June 2017 and May 2018. The 
      presence of left atrial LGE was assessed at nine left atrial segments; the extent 
      was determined by the number of segments involved. According to the chronicity of 
      AF, patients were separated into paroxysmal AF (PAF) and persistent AF (PeAF) 
      groups. The location and extent of left atrial LGE were compared between PAF and 
      PeAF by using the chi(2) test and logistic regression analysis. Results Of the 195 
      patients (mean age, 55 years +/- 10 [standard deviation], 161 men), 74 (38%) had 
      PAF and 121 (62%) had PeAF. Of all patients, 114 (58.4%) had at least one left 
      atrial LGE segment. The mean number of LGE segments was higher (1.4 +/- 1.1 vs 0.6 
      +/- 0.7, P = .002) in the PeAF group than in the PAF group. The incidence of LGE at 
      the left inferior pulmonary vein (LIPV) antrum was higher in the PeAF group than 
      in the PAF group (39.2% [29 of 74] vs 7.4% [nine of 121]; P < .001). In 
      multivariable analysis, LGE at the LIPV antrum was independently associated with 
      PeAF (odds ratio = 4.2; 95% confidence interval: 1.7, 10.5; P < .001). Conclusion 
      The presence of fibrosis assessed with late gadolinium enhancement MRI of the 
      left inferior pulmonary vein antrum was associated with persistent atrial 
      fibrillation. (c) RSNA, 2019 Online supplemental material is available for this 
      article. See also the editorial by Almeida in this issue.
FAU - Lee, Dong Kyu
AU  - Lee DK
AUID- ORCID: 0000-0002-8660-8943
AD  - From the Department of Radiology (D.K.L., Y.W.O., S.H.H.) and Division of 
      Cardiology, Department of Internal Medicine (J.S., J.i.C., Y.H.K.), Korea 
      University Anam Hospital, 73, Inchon-ro, Seoungbuk-gu, Seoul 02841, Republic of 
      Korea.
FAU - Shim, Jaemin
AU  - Shim J
AD  - From the Department of Radiology (D.K.L., Y.W.O., S.H.H.) and Division of 
      Cardiology, Department of Internal Medicine (J.S., J.i.C., Y.H.K.), Korea 
      University Anam Hospital, 73, Inchon-ro, Seoungbuk-gu, Seoul 02841, Republic of 
      Korea.
FAU - Choi, Jong-Il
AU  - Choi JI
AUID- ORCID: 0000-0001-6617-508X
AD  - From the Department of Radiology (D.K.L., Y.W.O., S.H.H.) and Division of 
      Cardiology, Department of Internal Medicine (J.S., J.i.C., Y.H.K.), Korea 
      University Anam Hospital, 73, Inchon-ro, Seoungbuk-gu, Seoul 02841, Republic of 
      Korea.
FAU - Kim, Young-Hoon
AU  - Kim YH
AUID- ORCID: 0000-0002-4254-647X
AD  - From the Department of Radiology (D.K.L., Y.W.O., S.H.H.) and Division of 
      Cardiology, Department of Internal Medicine (J.S., J.i.C., Y.H.K.), Korea 
      University Anam Hospital, 73, Inchon-ro, Seoungbuk-gu, Seoul 02841, Republic of 
      Korea.
FAU - Oh, Yu-Whan
AU  - Oh YW
AD  - From the Department of Radiology (D.K.L., Y.W.O., S.H.H.) and Division of 
      Cardiology, Department of Internal Medicine (J.S., J.i.C., Y.H.K.), Korea 
      University Anam Hospital, 73, Inchon-ro, Seoungbuk-gu, Seoul 02841, Republic of 
      Korea.
FAU - Hwang, Sung Ho
AU  - Hwang SH
AUID- ORCID: 0000-0003-1850-0751
AD  - From the Department of Radiology (D.K.L., Y.W.O., S.H.H.) and Division of 
      Cardiology, Department of Internal Medicine (J.S., J.i.C., Y.H.K.), Korea 
      University Anam Hospital, 73, Inchon-ro, Seoungbuk-gu, Seoul 02841, Republic of 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190716
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - Radiology. 2019 Jul 16;:191221. PMID: 31310578
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/*complications/*diagnostic imaging/pathology
MH  - Contrast Media/pharmacokinetics
MH  - Female
MH  - Fibrosis/complications/diagnostic imaging/pathology
MH  - Gadolinium/pharmacokinetics
MH  - Heart Atria/diagnostic imaging/pathology
MH  - Humans
MH  - Image Enhancement/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2019/07/17 06:00
MHDA- 2020/03/12 06:00
CRDT- 2019/07/17 06:00
PHST- 2019/07/17 06:00 [pubmed]
PHST- 2020/03/12 06:00 [medline]
PHST- 2019/07/17 06:00 [entrez]
AID - 10.1148/radiol.2019182629 [doi]
PST - ppublish
SO  - Radiology. 2019 Sep;292(3):575-582. doi: 10.1148/radiol.2019182629. Epub 2019 Jul 
      16.