PMID- 31310372
OWN - NLM
STAT- MEDLINE
DCOM- 20201105
LR  - 20201105
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 120
IP  - 12
DP  - 2019 Dec
TI  - Key modules and hub genes identified by coexpression network analysis for 
      revealing novel biomarkers for larynx squamous cell carcinoma.
PG  - 19832-19840
LID - 10.1002/jcb.29288 [doi]
AB  - Larynx squamous cell carcinoma (LSCC) is the second most aggressive head and neck 
      squamous cell carcinoma. Numerous genes have been identified to be aberrantly 
      expressed during the development of LSCC. However, currently, researchers focus 
      more on the individual molecule and downstream genes, leaving the coexpression 
      among genes and key upstream disease driver genes unexploited. In this study, we 
      applied weighted gene coexpression analysis (WGCNA) to decipher potential hub 
      genes driving the development of LSCC. After downloading of LSCC microarray 
      profile from gene expression omnibus, different expression analysis was 
      performed, which was used to conduct functional enrichment analysis. Then, we 
      applied WGCNA to highlight the hub genes which were relevant to the 
      carcinogenesis and progression. A total of 2858 differentially expressed genes 
      were identified in LSCC samples compared with adjacent non-neoplastic tissues. 
      WGCNA revealed three LSCC set-specific modules having significant Kyoto 
      Encyclopedia of Genes and Genomes enrichment effect, including pink, cyan, and 
      black module. Nine hub genes were identified to be crucial in LSCC onset and 
      progression, which may assist clinical decisions and serve as potential targets 
      for LSCC treatment.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Zhang, Hang
AU  - Zhang H
AUID- ORCID: 0000-0001-9573-1372
AD  - Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, China.
FAU - Zhao, Xudong
AU  - Zhao X
AD  - Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, China.
FAU - Wang, Mengmeng
AU  - Wang M
AD  - Sleep Medical Center, Shengjing Hospital, China Medical University, Shenyang, 
      China.
FAU - Ji, Wenyue
AU  - Ji W
AUID- ORCID: 0000-0001-5646-4603
AD  - Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190716
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - Cluster Analysis
MH  - *Gene Expression Regulation, Neoplastic
MH  - Gene Ontology
MH  - *Gene Regulatory Networks
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics
MH  - Squamous Cell Carcinoma of Head and Neck/*genetics
OTO - NOTNLM
OT  - GEO
OT  - GO
OT  - KEGG
OT  - WGCNA
OT  - hub genes
OT  - key modules
OT  - larynx squamous cell carcinoma
EDAT- 2019/07/17 06:00
MHDA- 2020/11/06 06:00
CRDT- 2019/07/17 06:00
PHST- 2019/04/28 00:00 [received]
PHST- 2019/06/18 00:00 [accepted]
PHST- 2019/07/17 06:00 [pubmed]
PHST- 2020/11/06 06:00 [medline]
PHST- 2019/07/17 06:00 [entrez]
AID - 10.1002/jcb.29288 [doi]
PST - ppublish
SO  - J Cell Biochem. 2019 Dec;120(12):19832-19840. doi: 10.1002/jcb.29288. Epub 2019 
      Jul 16.