PMID- 31310860
OWN - NLM
STAT- MEDLINE
DCOM- 20200204
LR  - 20200204
IS  - 1872-6232 (Electronic)
IS  - 0378-3782 (Linking)
VI  - 136
DP  - 2019 Sep
TI  - The association of the cerebral oxygenation during neonatal sepsis with the 
      Bayley-III Scale of Infant and Toddler Development index scores at 18-24 months 
      of age.
PG  - 49-53
LID - S0378-3782(19)30236-1 [pii]
LID - 10.1016/j.earlhumdev.2019.07.008 [doi]
AB  - BACKGROUND: Neonatal sepsis has been associated with poor neurodevelopmental 
      outcome, however the evidence regarding the exact mechanism of the inflammation 
      to the developing neonatal brain are inconclusive. AIMS: To investigate 
      association between cerebral oxygenation during neonatal sepsis and 
      neurodevelopmental outcome. STUDY DESIGN: Follow-up assessment of a previously 
      described prospective case-control study. SUBJECTS: A cohort of late preterm 
      (34-37 weeks' gestation) and preterm (<34 weeks' gestation) infants with sepsis 
      and healthy controls, evaluated at 18-24 months of corrected gestational age with 
      Bayley-III Scales for Infant and Toddler Development (BSID-III). OUTCOME 
      MEASURES: To evaluate the association between cerebral tissue oxygenation index 
      (cTOI) and fractional tissue oxygen extraction (FTOE), measured with 
      near-infrared spectroscopy, during sepsis and the composite cognitive and motor 
      index scores. RESULTS: Thirty-one infants with blood culture confirmed neonatal 
      sepsis and thirty-five controls were recruited. The cerebral oxygenation was 
      significantly lower in septic neonates, compared to controls (61 +/- 7 compared to 
      72 +/- 5; p < 0.001). Infants with sepsis had significantly lower cognitive and 
      motor index scores and higher proportion of suboptimal cognitive (16% compared to 
      3%, p = 0.045) and motor (16% compared to none, p = 0.008) index score. The low 
      mean cTOI and FTOE noted in septic infants were significantly associated with 
      worse cognitive and motor composite index scores. CONCLUSIONS: Infants with lower 
      cerebral oxygenation during neonatal sepsis are at increased risk of worse 
      cognitive and motor scores in the neurodevelopmental assessment.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Rallis, Dimitrios
AU  - Rallis D
AD  - 2nd Department of Neonatology, Papageorgiou Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece; Imperial College Healthcare NHS Trust, 
      London, UK. Electronic address: Dimitrios.rallis@nhs.net.
FAU - Karagianni, Paraskevi
AU  - Karagianni P
AD  - 2nd Department of Neonatology, Papageorgiou Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
FAU - Goutsiou, Evanthia
AU  - Goutsiou E
AD  - 2nd Department of Neonatology, Papageorgiou Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
FAU - Soubasi-Griva, Vasiliki
AU  - Soubasi-Griva V
AD  - 2nd Department of Neonatology, Papageorgiou Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
FAU - Banerjee, Jayanta
AU  - Banerjee J
AD  - Imperial College Healthcare NHS Trust, London, UK.
FAU - Tsakalidis, Christos
AU  - Tsakalidis C
AD  - 2nd Department of Neonatology, Papageorgiou Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
LA  - eng
PT  - Journal Article
DEP - 20190713
PL  - Ireland
TA  - Early Hum Dev
JT  - Early human development
JID - 7708381
SB  - IM
MH  - Brain/*diagnostic imaging/metabolism
MH  - Child, Preschool
MH  - Cognition
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Male
MH  - Motor Skills
MH  - Neonatal Sepsis/*epidemiology/physiopathology
MH  - Neurodevelopmental Disorders/*epidemiology
MH  - *Oxygen Consumption
MH  - Spectroscopy, Near-Infrared
EDAT- 2019/07/17 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/07/17 06:00
PHST- 2019/04/21 00:00 [received]
PHST- 2019/06/29 00:00 [revised]
PHST- 2019/07/06 00:00 [accepted]
PHST- 2019/07/17 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/07/17 06:00 [entrez]
AID - S0378-3782(19)30236-1 [pii]
AID - 10.1016/j.earlhumdev.2019.07.008 [doi]
PST - ppublish
SO  - Early Hum Dev. 2019 Sep;136:49-53. doi: 10.1016/j.earlhumdev.2019.07.008. Epub 
      2019 Jul 13.