PMID- 31311499
OWN - NLM
STAT- MEDLINE
DCOM- 20200124
LR  - 20200225
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 19
IP  - 1
DP  - 2019 Jul 16
TI  - A prospective study on endoscopic ultrasound for the differential diagnosis of 
      serous cystic neoplasms and mucinous cystic neoplasms.
PG  - 127
LID - 10.1186/s12876-019-1035-8 [doi]
LID - 127
AB  - BACKGROUND: To provide criteria for the differential diagnosis of serous cystic 
      neoplasms (SCNs) and mucinous cystic neoplasms (MCNs) by analyzing the imaging 
      features of these two neoplasms by endoscopic ultrasound (EUS). METHODS: From 
      April 2015 to December 2017, a total of 69 patients were enrolled in this study. 
      All patients were confirmed to have MCNs (31 patients) or SCNs (38 patients) by 
      surgical pathology. All patients underwent EUS examination. The observation and 
      recorded items were size, location, shape, cystic wall thickness, number of 
      septa, and solid components. RESULTS: Head/neck location, lobulated shape, thin 
      wall and > 2 septa were the specific imaging features for the diagnosis of SCNs. 
      When any two imaging features were combined, we achieved the highest area under 
      the curve (Az) (0.824), as well as the appropriate sensitivity (84.2%), 
      specificity (80.6%), positive predictive value (PPV) (84.2%), and negative 
      predictive value (NPV) (80.6%). Body/tail location, round shape, thick wall and 
      0-2 septa were the specific imaging features for the diagnosis of MCNs. When any 
      three imaging features were combined, we obtained the highest Az value (0.808), 
      as well as the appropriate sensitivity (77.4%), specificity (84.2%), PPV (80.0%) 
      and NPV (82.1%). CONCLUSIONS: Pancreatic cystadenomas that meet any two of the 
      four imaging features of head/neck location, lobulated shape, thin wall and > 2 
      septa could be diagnosed as SCNs, and those that meet any three of the four 
      imaging features of body/tail location, round shape, thick wall and 0-2 septa 
      could be considered as MCNs. TRIAL REGISTRATION: The study was registered at the 
      Chinese Clinical Trial Registry. The registration identification number is 
      ChiCTR-OOC-15006118 . The date of registration is 2015-03-20.
FAU - Zhong, Lisen
AU  - Zhong L
AD  - Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China.
FAU - Chai, Ningli
AU  - Chai N
AD  - Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China.
FAU - Linghu, Enqiang
AU  - Linghu E
AD  - Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China. 
      linghuenqiang@vip.sina.com.
FAU - Li, Huikai
AU  - Li H
AD  - Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China.
FAU - Yang, Jing
AU  - Yang J
AD  - Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China.
FAU - Tang, Ping
AU  - Tang P
AD  - Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, 
      Fuxing Road 28, Haidian District, Beijing, 100853, China.
LA  - eng
PT  - Journal Article
DEP - 20190716
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
SB  - IM
MH  - Adult
MH  - China
MH  - *Cystadenoma, Mucinous/diagnosis/pathology
MH  - *Cystadenoma, Serous/diagnosis/pathology
MH  - Diagnosis, Differential
MH  - Endosonography/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pancreas/*diagnostic imaging/pathology
MH  - *Pancreatic Neoplasms/diagnosis/pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Sensitivity and Specificity
PMC - PMC6636106
OTO - NOTNLM
OT  - Diagnosis
OT  - Endoscopic ultrasound
OT  - Mucinous cystic neoplasm
OT  - Pancreatic cystic neoplasm
OT  - Serous cystic neoplasm
COIS- The authors declare that they have no competing interests.
EDAT- 2019/07/18 06:00
MHDA- 2020/01/25 06:00
PMCR- 2019/07/16
CRDT- 2019/07/18 06:00
PHST- 2019/03/10 00:00 [received]
PHST- 2019/06/24 00:00 [accepted]
PHST- 2019/07/18 06:00 [entrez]
PHST- 2019/07/18 06:00 [pubmed]
PHST- 2020/01/25 06:00 [medline]
PHST- 2019/07/16 00:00 [pmc-release]
AID - 10.1186/s12876-019-1035-8 [pii]
AID - 1035 [pii]
AID - 10.1186/s12876-019-1035-8 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2019 Jul 16;19(1):127. doi: 10.1186/s12876-019-1035-8.