PMID- 31313754
OWN - NLM
STAT- MEDLINE
DCOM- 20200213
LR  - 20200225
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 25
DP  - 2019 Jul 17
TI  - Culprit Lesion Characteristics in Young Patients with Hyperhomocysteinemia.
PG  - 5306-5311
LID - 10.12659/MSM.914979 [doi]
AB  - BACKGROUND The relationships between culprit coronary plaque characteristics and 
      hyperhomocysteinemia (HHcy) are not fully understood in young patients. In this 
      study we investigated the relationship between culprit atherosclerotic plaque 
      phenotype assessed by optical coherence tomography (OCT) and hyperhomocysteinemia 
      (HHcy) in young patients. MATERIAL AND METHODS We investigated the OCT imaging 
      and HHcy of 123 lesions in 123 young patients (</=45 years of age). According to 
      OCT images, culprit lesions were classified as thin-cap fiber atheroma (TCFA), 
      thrombus, and other. The 123 patients were grouped as: HHcy group (53 cases, HHcy 
      >/=15.5 micromol/l) and control group (70 cases, HHcy <15.5 micromol/l). RESULTS Compared 
      with the control group, the HHcy group had a higher proportion of OCT-TCFA 
      (p=0.03), OCT-vasa vasorum (p=0.013), and OCT-thrombus (p=0.012), and a larger 
      lipid arc (p=0.002). HHcy (P=0.037) and metabolic syndrome (MetS) (P=0.016) 
      remained independent predictors of TCFAs. HHcy (P=0.026) and smoking (P=0.005) 
      remained independent determinants of thrombus. CONCLUSIONS HHcy and MetS are 
      associated with TCFAs, and HHcy and smoking are associated with thrombus in young 
      patients with coronary artery disease.
FAU - Hou, Fang-Jie
AU  - Hou FJ
AD  - Department of Cardiology, 12th Ward, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key 
      Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical 
      Center for Coronary Heart Disease, Beijing, China (mainland).
AD  - Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China 
      (mainland).
FAU - Zhou, Yu-Jie
AU  - Zhou YJ
AD  - Department of Cardiology, 12th Ward, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key 
      Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical 
      Center for Coronary Heart Disease, Beijing, China (mainland).
FAU - Ma, Xiao-Teng
AU  - Ma XT
AD  - Department of Cardiology, 12th Ward, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key 
      Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical 
      Center for Coronary Heart Disease, Beijing, China (mainland).
FAU - He, Tao
AU  - He T
AD  - Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China 
      (mainland).
FAU - Yan, Rong-Qiang
AU  - Yan RQ
AD  - Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China 
      (mainland).
FAU - Geng, Qiang
AU  - Geng Q
AD  - Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China 
      (mainland).
FAU - Wang, Hai-Yang
AU  - Wang HY
AD  - Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China 
      (mainland).
FAU - Ma, Ying
AU  - Ma Y
AD  - Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China 
      (mainland).
FAU - Ren, Yong-Qiang
AU  - Ren YQ
AD  - Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China 
      (mainland).
FAU - Dong, Fu-Zong
AU  - Dong FZ
AD  - Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong, China 
      (mainland).
LA  - eng
PT  - Journal Article
DEP - 20190717
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
SB  - IM
MH  - Acute Coronary Syndrome/complications
MH  - Adult
MH  - China
MH  - Coronary Angiography/methods
MH  - Coronary Artery Disease/*complications/etiology
MH  - Coronary Vessels/pathology
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*physiopathology
MH  - Male
MH  - Overweight
MH  - Plaque, Atherosclerotic/metabolism/*pathology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Smoking
MH  - Tomography, Optical Coherence/methods
PMC - PMC6659466
COIS- Conflicts of interest None.
EDAT- 2019/07/18 06:00
MHDA- 2020/02/14 06:00
PMCR- 2019/07/17
CRDT- 2019/07/18 06:00
PHST- 2019/07/18 06:00 [entrez]
PHST- 2019/07/18 06:00 [pubmed]
PHST- 2020/02/14 06:00 [medline]
PHST- 2019/07/17 00:00 [pmc-release]
AID - 914979 [pii]
AID - 10.12659/MSM.914979 [doi]
PST - epublish
SO  - Med Sci Monit. 2019 Jul 17;25:5306-5311. doi: 10.12659/MSM.914979.