PMID- 31315136
OWN - NLM
STAT- MEDLINE
DCOM- 20200428
LR  - 20230202
IS  - 1098-8971 (Electronic)
IS  - 0272-8087 (Linking)
VI  - 39
IP  - 4
DP  - 2019 Nov
TI  - Effects of Antibiotic Therapy in Primary Sclerosing Cholangitis with and without 
      Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
PG  - 432-441
LID - 10.1055/s-0039-1688501 [doi]
AB  - The authors conducted a systematic review and meta-analysis to assess the effect 
      of antibiotic therapy in primary sclerosing cholangitis (PSC). Effect of 
      antibiotic therapy on Mayo PSC Risk Score (MRS), serum alkaline phosphatase 
      (ALP), total serum bilirubin (TSB), and adverse events (AEs) rates were 
      calculated and expressed as standardized difference of means or proportions. Five 
      studies including 124 PSC patients who received antibiotics were included. 
      Overall, antibiotic treatment was associated with a statistically significant 
      reduction in ALP, MRS, and TSB by 33.2, 36.1, and 28.8%, respectively. ALP 
      reduction was greatest for vancomycin (65.6%, p < 0.002) and smallest with 
      metronidazole (22.7%, p = 0.18). Overall, 8.9% (95% confidence interval: 
      3.9-13.9) of patients had AEs severe enough to discontinue antibiotic therapy. In 
      PSC patients, antibiotic treatment results in a significant improvement in 
      markers of cholestasis and MRS. Antibiotics, particularly vancomycin, may have a 
      positive effect on PSC either via direct effects on the microbiome or via 
      host-mediated mechanisms.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Shah, Ayesha
AU  - Shah A
AD  - Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
AD  - Department of Gastroenterology & Hepatology, Princess Alexandra Hospital, 
      Brisbane, QLD, Australia.
AD  - Translational Research Institute, Princess Alexandra Hospital, Brisbane, QLD, 
      Australia.
FAU - Crawford, Darrel
AU  - Crawford D
AD  - Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
AD  - Gallipoli Research Foundation, Brisbane, QLD Australia.
FAU - Burger, Daniel
AU  - Burger D
AD  - Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
AD  - Department of Gastroenterology & Hepatology, Princess Alexandra Hospital, 
      Brisbane, QLD, Australia.
FAU - Martin, Neal
AU  - Martin N
AD  - Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
AD  - Department of Gastroenterology & Hepatology, Princess Alexandra Hospital, 
      Brisbane, QLD, Australia.
FAU - Walker, Marjorie
AU  - Walker M
AD  - Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 
      Australia.
FAU - Talley, Nicholas J
AU  - Talley NJ
AD  - Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 
      Australia.
FAU - Tallis, Caroline
AU  - Tallis C
AD  - Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
AD  - Department of Gastroenterology & Hepatology, Princess Alexandra Hospital, 
      Brisbane, QLD, Australia.
FAU - Jones, Michael
AU  - Jones M
AD  - Department of Psychology, Macquarie University, Sydney, NSW, Australia.
FAU - Stuart, Katherine
AU  - Stuart K
AD  - Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
AD  - Department of Gastroenterology & Hepatology, Princess Alexandra Hospital, 
      Brisbane, QLD, Australia.
FAU - Keely, Simon
AU  - Keely S
AD  - Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW 
      Australia.
FAU - Lewindon, Peter
AU  - Lewindon P
AD  - Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
AD  - Lady Cilento Children's Hospital, South Brisbane, QLD, Australia.
FAU - Macdonald, Graeme A
AU  - Macdonald GA
AD  - Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
AD  - Department of Gastroenterology & Hepatology, Princess Alexandra Hospital, 
      Brisbane, QLD, Australia.
FAU - Morrison, Mark
AU  - Morrison M
AD  - Department of Microbial Biology and Metagenomics, Diamantina Institute, 
      University of Queensland, Woolloongabba, Brisbane, QLD, Australia.
FAU - Holtmann, Gerald J
AU  - Holtmann GJ
AD  - Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
AD  - Department of Gastroenterology & Hepatology, Princess Alexandra Hospital, 
      Brisbane, QLD, Australia.
AD  - Translational Research Institute, Princess Alexandra Hospital, Brisbane, QLD, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20190717
PL  - United States
TA  - Semin Liver Dis
JT  - Seminars in liver disease
JID - 8110297
RN  - 0 (Anti-Bacterial Agents)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
CIN - Indian J Gastroenterol. 2022 Oct;41(5):519-524. PMID: 36217097
MH  - Alkaline Phosphatase/blood
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Bilirubin/blood
MH  - Cholangitis, Sclerosing/complications/*drug therapy
MH  - Humans
MH  - Inflammatory Bowel Diseases/*complications
COIS- None declared.
EDAT- 2019/07/18 06:00
MHDA- 2020/04/29 06:00
CRDT- 2019/07/18 06:00
PHST- 2019/07/18 06:00 [pubmed]
PHST- 2020/04/29 06:00 [medline]
PHST- 2019/07/18 06:00 [entrez]
AID - 10.1055/s-0039-1688501 [doi]
PST - ppublish
SO  - Semin Liver Dis. 2019 Nov;39(4):432-441. doi: 10.1055/s-0039-1688501. Epub 2019 
      Jul 17.