PMID- 31315230
OWN - NLM
STAT- MEDLINE
DCOM- 20200109
LR  - 20200225
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 7
DP  - 2019 Jul 16
TI  - Central But Not General Obesity Is Positively Associated with the Risk of 
      Hyperhomocysteinemia in Middle-Aged Women.
LID - 10.3390/nu11071614 [doi]
LID - 1614
AB  - OBJECTIVE: Obesity and homocysteine (Hcy) are two important risk factors for 
      cardiovascular disease (CVD). However, evidence on the association between 
      obesity and Hcy concentration was conflicting. The aim of our study is to explore 
      the associations of general and central obesity with hyperhomocysteinemia (HHcy) 
      in middle-aged women. METHODS: The current analysis was based on data from 11,007 
      women aged 40-60 years. Height, weight, and waist circumference (WC) were 
      measured and serum homocysteine was determined. Multiple logistic regression 
      models were used to assess the associations of the risk of hyperhomocysteinemia 
      (HHcy, Hcy > 15 mumol/L) with BMI and WC. RESULTS: 13.71% women had HHcy. The 
      prevalences of BMI-based general obesity and WC-based central obesity were 11.17% 
      and 22.88%, respectively. Compared with non-obese women, the mean serum Hcy 
      concentration was significantly higher in WC-based central obese women (p = 
      0.002), but not in BMI-based general obese women (p > 0.05). In the multiple 
      logistic regression models, central obesity was positively related to the risk of 
      HHcy (OR = 1.30, 95% CI = 1.10 to 1.52), while general obesity was inversely 
      related to the risk of HHcy (OR = 0.82, 95% CI = 0.72 to 0.93 and OR = 0.71, 95% 
      CI = 0.57 to 0.89). CONCLUSIONS: Central obesity was positively related to the 
      risk of HHcy, while general obesity was negatively related. Menopause showed no 
      effect modification on these associations.
FAU - Wang, Yingying
AU  - Wang Y
AUID- ORCID: 0000-0002-8426-4526
AD  - Department of Epidemiology, School of Public Health, Fudan University, NO 130, 
      Dongan Road, Xuhui District, Shanghai 200032, China.
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, 
      China.
FAU - Jiang, Yonggen
AU  - Jiang Y
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201620, 
      China.
FAU - Wang, Na
AU  - Wang N
AD  - Department of Epidemiology, School of Public Health, Fudan University, NO 130, 
      Dongan Road, Xuhui District, Shanghai 200032, China. na.wang@fudan.edu.cn.
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, 
      China. na.wang@fudan.edu.cn.
FAU - Zhu, Meiying
AU  - Zhu M
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201620, 
      China.
FAU - Liu, Xing
AU  - Liu X
AD  - Department of Epidemiology, School of Public Health, Fudan University, NO 130, 
      Dongan Road, Xuhui District, Shanghai 200032, China.
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, 
      China.
FAU - Wang, Ruiping
AU  - Wang R
AD  - Songjiang District Center for Disease Control and Prevention, Shanghai 201620, 
      China.
FAU - Jiang, Feng
AU  - Jiang F
AD  - Department of Epidemiology, School of Public Health, Fudan University, NO 130, 
      Dongan Road, Xuhui District, Shanghai 200032, China.
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, 
      China.
FAU - Chen, Yue
AU  - Chen Y
AD  - School of Epidemiology and Public Health, Faculty of Medicine, University of 
      Ottawa, Ottawa, ON K1G 5Z3, Canada.
FAU - Zhao, Qi
AU  - Zhao Q
AD  - Department of Epidemiology, School of Public Health, Fudan University, NO 130, 
      Dongan Road, Xuhui District, Shanghai 200032, China.
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, 
      China.
FAU - Zhao, Genming
AU  - Zhao G
AD  - Department of Epidemiology, School of Public Health, Fudan University, NO 130, 
      Dongan Road, Xuhui District, Shanghai 200032, China.
AD  - Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, 
      China.
LA  - eng
GR  - 2017YFC0907000/the National Key Research and Development Program of China/
PT  - Journal Article
DEP - 20190716
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*etiology
MH  - Middle Aged
MH  - Obesity/*complications
MH  - Odds Ratio
MH  - Risk Factors
PMC - PMC6683268
OTO - NOTNLM
OT  - cardiovascular disease
OT  - central obesity
OT  - homocysteine
OT  - menopause
COIS- The authors declared no conflict of interest.
EDAT- 2019/07/19 06:00
MHDA- 2020/01/10 06:00
PMCR- 2019/07/01
CRDT- 2019/07/19 06:00
PHST- 2019/06/22 00:00 [received]
PHST- 2019/07/08 00:00 [revised]
PHST- 2019/07/11 00:00 [accepted]
PHST- 2019/07/19 06:00 [entrez]
PHST- 2019/07/19 06:00 [pubmed]
PHST- 2020/01/10 06:00 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - nu11071614 [pii]
AID - nutrients-11-01614 [pii]
AID - 10.3390/nu11071614 [doi]
PST - epublish
SO  - Nutrients. 2019 Jul 16;11(7):1614. doi: 10.3390/nu11071614.