PMID- 31315681
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20200225
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 18
IP  - 1
DP  - 2019 Jul 17
TI  - Epidemiological characteristics and risk factors of T2DM in Chinese premenopausal 
      and postmenopausal women.
PG  - 155
LID - 10.1186/s12944-019-1091-7 [doi]
LID - 155
AB  - OBJECTIVE: This study was to analyse the prevalence of type 2 diabetes mellitus 
      (T2DM) in premenopausal and postmenopausal women. METHODS: A total of 3227 women 
      met the requirements from June to December in 2014, including 207 cases of 
      premenopausal women and 3020 cases of postmenopausal women. The prevalence of 
      T2DM and the associated risk factors in the two groups were analysed. RESULTS: 
      The prevalence of premenopausal women with T2DM was 12.1%, while the prevalence 
      in postmenopausal women was 19.4% (P < 0.05). Total serum protein (TP) 
      (OR = 1.164 95% CI = 1.023-1.324) (P = 0.021) is a major risk factor for 
      premenopausal women with T2DM. The prevalence of T2DM increased with the increase 
      in TP. In postmenopausal groups, the prevalence of T2DM was associated with age 
      (OR = 1.037 95% CI = 1.024-1.051) (P < 0.001), BMI (OR = 1.076 95% 
      CI = 1.044-1.109) (P < 0.001), blood pressure (OR = 1.521 95% CI = 1.234-1.875) 
      (P < 0.001), triglycerides (TG) (OR = 1.106 95% CI = 1.027-1.190) (P = 0.008), 
      blood urea nitrogen (BUN) (OR = 1.065 95% CI = 1.004-1.129) (P = 0.036), alanine 
      aminotransferase (ALT) (OR = 1.009 95% CI = 1.003-1.016) (P = 0.004) and TP 
      (OR = 1.031 95% CI = 1.005-1.057) (P = 0.018). CONCLUSIONS: Postmenopausal women 
      have a higher rate of type 2 diabetes than premenopausal women. TP is a major 
      risk factor for premenopausal women with T2DM. TP, ALT, and BUN are 
      postmenopausal risk factors in addition to traditional risk factors such as 
      obesity, lipidaemia and blood pressure. We should monitor risk factors and take 
      early prevention and intervention measures to reduce the prevalence of diabetes 
      and improve the quality of life of postmenopausal women. TRIAL REGISTRATION: 
      ChiCTR, ChiCTR-TRC-14005029. Registered 29 July 2014, 
      http://www.chictr.org.cn/showproj.aspx?proj=4545.
FAU - Li, Qingjun
AU  - Li Q
AD  - Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou 
      Medical College and Huai'an Second People's Hospital, Huai'an, 223001, China.
FAU - Wang, Xiaoqing
AU  - Wang X
AD  - Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou 
      Medical College and Huai'an Second People's Hospital, Huai'an, 223001, China.
FAU - Ni, Yaojun
AU  - Ni Y
AD  - Department of Cardiothoracic Surgery, Hospital Affiliated to Nanjing Medical 
      College and Huai'an First People's Hospital, Huai'an, 223001, China.
FAU - Hao, Hairong
AU  - Hao H
AD  - Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou 
      Medical College and Huai'an Second People's Hospital, Huai'an, 223001, China.
FAU - Liu, Ziyu
AU  - Liu Z
AD  - Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou 
      Medical College and Huai'an Second People's Hospital, Huai'an, 223001, China.
FAU - Wen, Surong
AU  - Wen S
AD  - Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou 
      Medical College and Huai'an Second People's Hospital, Huai'an, 223001, China.
FAU - Shao, Xiaojuan
AU  - Shao X
AD  - Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou 
      Medical College and Huai'an Second People's Hospital, Huai'an, 223001, China.
FAU - Wu, Xiaojuan
AU  - Wu X
AD  - Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou 
      Medical College and Huai'an Second People's Hospital, Huai'an, 223001, China.
FAU - Yu, Weinan
AU  - Yu W
AD  - Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou 
      Medical College and Huai'an Second People's Hospital, Huai'an, 223001, China. 
      yuweinanha@163.com.
FAU - Hu, Wen
AU  - Hu W
AD  - Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou 
      Medical College and Huai'an Second People's Hospital, Huai'an, 223001, China. 
      huwen787878@163.com.
LA  - eng
GR  - Grant Z201317/Health Department Fund Projects of Jiangsu Province/
GR  - Grant 81700776/the National Natural Sciences Foundation of China/
PT  - Journal Article
DEP - 20190717
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Blood Proteins)
RN  - 0 (Triglycerides)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alanine Transaminase/blood
MH  - Blood Proteins/*analysis
MH  - Blood Urea Nitrogen
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/*blood/*epidemiology
MH  - Female
MH  - Humans
MH  - Hypertension/epidemiology
MH  - Logistic Models
MH  - Middle Aged
MH  - Postmenopause
MH  - Premenopause
MH  - Prevalence
MH  - Risk Factors
MH  - Triglycerides/blood
PMC - PMC6637604
OTO - NOTNLM
OT  - Menopausal
OT  - Prevalence
OT  - Risk factors
OT  - T2DM
COIS- The authors declare that they have no competing interests.
EDAT- 2019/07/19 06:00
MHDA- 2019/12/31 06:00
PMCR- 2019/07/17
CRDT- 2019/07/19 06:00
PHST- 2018/11/25 00:00 [received]
PHST- 2019/06/20 00:00 [accepted]
PHST- 2019/07/19 06:00 [entrez]
PHST- 2019/07/19 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
PHST- 2019/07/17 00:00 [pmc-release]
AID - 10.1186/s12944-019-1091-7 [pii]
AID - 1091 [pii]
AID - 10.1186/s12944-019-1091-7 [doi]
PST - epublish
SO  - Lipids Health Dis. 2019 Jul 17;18(1):155. doi: 10.1186/s12944-019-1091-7.