PMID- 31315775
OWN - NLM
STAT- MEDLINE
DCOM- 20190723
LR  - 20211204
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 21
IP  - 7
DP  - 2019 Jul
TI  - [Research advances in the role of mTOR signaling pathway in autism spectrum 
      disorder].
PG  - 718-723
AB  - Mammalian target of rapamycin (mTOR) is an intracellular signaling pathway 
      molecule which regulates various fundamental physiological processes. The mTOR 
      signaling pathway plays an important role in synaptic plasticity, information 
      transmission and processing, and neuroregulation. Dysregulation of the mTOR 
      signaling pathway is generally considered to be related to the pathogenesis of 
      autism spectrum disorder (ASD); meanwhile, the mTOR inhibitor can ameliorate the 
      symptoms of ASD. The role of mTOR in the pathogenesis of ASD is summarized in 
      this article to provide a theoretical basis for targeted therapy of ASD.
FAU - Sheng, Guo-Xia
AU  - Sheng GX
AD  - Department of Neurology, Children's Hospital of Zhejiang University, Hangzhou 
      310000, China. jiangkw_zju@zju.edu.cn.
FAU - Jiang, Ke-Wen
AU  - Jiang KW
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
MH  - Animals
MH  - *Autism Spectrum Disorder
MH  - Humans
MH  - Signal Transduction
MH  - Sirolimus
MH  - TOR Serine-Threonine Kinases
PMC - PMC7389111
EDAT- 2019/07/19 06:00
MHDA- 2019/07/25 06:00
PMCR- 2019/07/25
CRDT- 2019/07/19 06:00
PHST- 2019/07/19 06:00 [entrez]
PHST- 2019/07/19 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
PHST- 2019/07/25 00:00 [pmc-release]
AID - 10.7499/j.issn.1008-8830.2019.07.019 [pii]
AID - zgddekzz-21-7-718 [pii]
AID - 10.7499/j.issn.1008-8830.2019.07.019 [doi]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2019 Jul;21(7):718-723. doi: 
      10.7499/j.issn.1008-8830.2019.07.019.