PMID- 31315894
OWN - NLM
STAT- MEDLINE
DCOM- 20191223
LR  - 20221207
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 73
IP  - 1
DP  - 2020 Jan
TI  - Detection of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) DNA in 
      endocervical samples from a positive and negative HPV woman of Cordoba, 
      Argentina.
PG  - 30-34
LID - 10.1136/jclinpath-2019-205795 [doi]
AB  - AIMS: The purpose of the present study was to elucidate the presence of human 
      herpesvirus 6A (HHV-6A), HHV-6B and HHV-7 in samples of the uterine cervix 
      through detection of viral DNA. We analysed normal tissues, samples with 
      low-grade squamous intraepithelial lesions (LSILs) and high-grade squamous 
      intraepithelial lesions (HSILs). We correlated the presence of HHV-6 and HHV-7 
      with the finding of human papillomavirus (HPV) in mucosal samples. METHODS: 
      Cervical samples were examined and grouped as follows: group 1 (n=29), normal 
      cytology; group 2 (n=61), samples with LSIL; group 3 (n=35), samples with HSIL. 
      Molecular biology examinations were performed in all samples to detect HHV-6, 
      HHV-7 and HPV DNA and to typify HHV-6 species. RESULTS: Group 1: normal cytology 
      and HPV (-): HHV-6: 6.8% (2/29), HHV-7: 79.3% (23/29); group 2: LSIL and HPV (-): 
      HHV-6: 93.1% (27/29), HHV-7: 96.5% (28/29); LSIL and HPV (+): HHV-6: 0% (0/32), 
      HHV-7: 90.6% (29/32); group 3: HSIL and HPV (-): HHV-6: 20% (2/10), HHV-7: 70% 
      (7/10); HSIL HPV (+): HHV-6: 12% (3/25), HHV-7: 68% (17/25). HHV-6A DNA was not 
      detected in any samples. CONCLUSIONS: (1) Both HHV-6 and HHV-7 infect the mucosal 
      cells of the cervix with higher prevalence of HHV-7. (2) The higher prevalence of 
      HHV-6 in LSIL HPV (-) samples compared with those with normal cytology indicates 
      that it constitutes a possible risk factor for atypia production. (3) The 
      presence of HHV-7 in all samples questions its role in the production of atypia. 
      (4) The finding of HHV-6 and HHV-7 suggests that the cervical mucosa is a 
      possible transmission pathway for these viruses.
CI  - (c) Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Biganzoli, Patricia
AU  - Biganzoli P
AUID- ORCID: 0000-0002-4902-6813
AD  - Virology Institute 'Dr. J. Vanella', School of Medical Sciences, National 
      University of Cordoba, Cordoba, Cordoba, Argentina patricia.biganzoli@gmail.com.
AD  - Medical Bacteriology and Virology, School of Medical Sciences, National 
      University of Cordoba, Cordoba, Argentina.
FAU - Frutos, Maria Celia
AU  - Frutos MC
AD  - Virology Institute 'Dr. J. Vanella', School of Medical Sciences, National 
      University of Cordoba, Cordoba, Cordoba, Argentina.
FAU - Venezuela, Fernando
AU  - Venezuela F
AD  - Virology Institute 'Dr. J. Vanella', School of Medical Sciences, National 
      University of Cordoba, Cordoba, Cordoba, Argentina.
FAU - Mosmann, Jessica
AU  - Mosmann J
AD  - Virology Institute 'Dr. J. Vanella', School of Medical Sciences, National 
      University of Cordoba, Cordoba, Cordoba, Argentina.
FAU - Kiguen, Ana
AU  - Kiguen A
AD  - Virology Institute 'Dr. J. Vanella', School of Medical Sciences, National 
      University of Cordoba, Cordoba, Cordoba, Argentina.
FAU - Pavan, Jorge
AU  - Pavan J
AD  - Virology Institute 'Dr. J. Vanella', School of Medical Sciences, National 
      University of Cordoba, Cordoba, Cordoba, Argentina.
AD  - Medical Bacteriology and Virology, School of Medical Sciences, National 
      University of Cordoba, Cordoba, Argentina.
FAU - Ferreyra, Leonardo
AU  - Ferreyra L
AD  - Virology Institute 'Dr. J. Vanella', School of Medical Sciences, National 
      University of Cordoba, Cordoba, Cordoba, Argentina.
AD  - Medical Bacteriology and Virology, School of Medical Sciences, National 
      University of Cordoba, Cordoba, Argentina.
FAU - Cuffini, Cecilia
AU  - Cuffini C
AD  - Virology Institute 'Dr. J. Vanella', School of Medical Sciences, National 
      University of Cordoba, Cordoba, Cordoba, Argentina.
LA  - eng
PT  - Journal Article
DEP - 20190717
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Argentina
MH  - DNA, Viral/*genetics
MH  - Female
MH  - Herpesvirus 6, Human/*genetics
MH  - Herpesvirus 7, Human/*genetics
MH  - Human Papillomavirus DNA Tests
MH  - Humans
MH  - Middle Aged
MH  - *Molecular Diagnostic Techniques
MH  - Papillomaviridae/genetics
MH  - Papillomavirus Infections/diagnosis/genetics/virology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Roseolovirus Infections/*diagnosis/genetics/transmission/virology
MH  - Squamous Intraepithelial Lesions of the Cervix/*diagnosis/genetics/virology
MH  - Uterine Cervical Neoplasms/*diagnosis/genetics/virology
MH  - Young Adult
MH  - Uterine Cervical Dysplasia/*diagnosis/genetics/virology
OTO - NOTNLM
OT  - gynecological pathology
OT  - human papillomavirus
OT  - virus
COIS- Competing interests: None declared.
EDAT- 2019/07/19 06:00
MHDA- 2019/12/24 06:00
CRDT- 2019/07/19 06:00
PHST- 2019/02/21 00:00 [received]
PHST- 2019/06/24 00:00 [revised]
PHST- 2019/06/28 00:00 [accepted]
PHST- 2019/07/19 06:00 [pubmed]
PHST- 2019/12/24 06:00 [medline]
PHST- 2019/07/19 06:00 [entrez]
AID - jclinpath-2019-205795 [pii]
AID - 10.1136/jclinpath-2019-205795 [doi]
PST - ppublish
SO  - J Clin Pathol. 2020 Jan;73(1):30-34. doi: 10.1136/jclinpath-2019-205795. Epub 
      2019 Jul 17.