PMID- 31316205
OWN - NLM
STAT- MEDLINE
DCOM- 20191126
LR  - 20211204
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 572
IP  - 7767
DP  - 2019 Aug
TI  - A calmodulin-gated calcium channel links pathogen patterns to plant immunity.
PG  - 131-135
LID - 10.1038/s41586-019-1413-y [doi]
AB  - Pathogen-associated molecular patterns (PAMPs) activate innate immunity in both 
      animals and plants. Although calcium has long been recognized as an essential 
      signal for PAMP-triggered immunity in plants, the mechanism of PAMP-induced 
      calcium signalling remains unknown(1,2). Here we report that calcium nutrient 
      status is critical for calcium-dependent PAMP-triggered immunity in plants. When 
      calcium supply is sufficient, two genes that encode cyclic nucleotide-gated 
      channel (CNGC) proteins, CNGC2 and CNGC4, are essential for PAMP-induced calcium 
      signalling in Arabidopsis(3-7). In a reconstitution system, we find that the 
      CNGC2 and CNGC4 proteins together-but neither alone-assemble into a functional 
      calcium channel that is blocked by calmodulin in the resting state. Upon pathogen 
      attack, the channel is phosphorylated and activated by the effector kinase 
      BOTRYTIS-INDUCED KINASE1 (BIK1) of the pattern-recognition receptor complex, and 
      this triggers an increase in the concentration of cytosolic calcium(8-10). The 
      CNGC-mediated calcium entry thus provides a critical link between the 
      pattern-recognition receptor complex and calcium-dependent immunity programs in 
      the PAMP-triggered immunity signalling pathway in plants.
FAU - Tian, Wang
AU  - Tian W
AD  - Department of Plant and Microbial Biology, University of California, Berkeley, 
      CA, USA.
FAU - Hou, Congcong
AU  - Hou C
AD  - Department of Plant and Microbial Biology, University of California, Berkeley, 
      CA, USA.
FAU - Ren, Zhijie
AU  - Ren Z
AD  - College of Life Sciences, Capital Normal University, Beijing, China.
FAU - Wang, Chao
AU  - Wang C
AD  - Department of Plant and Microbial Biology, University of California, Berkeley, 
      CA, USA.
FAU - Zhao, Fugeng
AU  - Zhao F
AD  - Nanjing University-Nanjing Forestry University Joint Institute for Plant 
      Molecular Biology, College of Life Sciences, Nanjing University, Nanjing, China.
FAU - Dahlbeck, Douglas
AU  - Dahlbeck D
AD  - Department of Plant and Microbial Biology, University of California, Berkeley, 
      CA, USA.
FAU - Hu, Songping
AU  - Hu S
AD  - Department of Plant and Microbial Biology, University of California, Berkeley, 
      CA, USA.
FAU - Zhang, Liying
AU  - Zhang L
AD  - College of Life Sciences, Capital Normal University, Beijing, China.
FAU - Niu, Qi
AU  - Niu Q
AD  - College of Life Sciences, Capital Normal University, Beijing, China.
FAU - Li, Legong
AU  - Li L
AD  - College of Life Sciences, Capital Normal University, Beijing, China.
FAU - Staskawicz, Brian J
AU  - Staskawicz BJ
AD  - Department of Plant and Microbial Biology, University of California, Berkeley, 
      CA, USA.
FAU - Luan, Sheng
AU  - Luan S
AD  - Department of Plant and Microbial Biology, University of California, Berkeley, 
      CA, USA. sluan@berkeley.edu.
LA  - eng
PT  - Journal Article
DEP - 20190717
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (ATCNGC4 protein, Arabidopsis)
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (CNGC2 protein, Arabidopsis)
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Calmodulin)
RN  - 0 (Cyclic Nucleotide-Gated Cation Channels)
RN  - 0 (Pathogen-Associated Molecular Pattern Molecules)
RN  - 0 (Reactive Oxygen Species)
RN  - EC 2.7.11.1 (BIK1 protein, Arabidopsis)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
CIN - Trends Plant Sci. 2019 Dec;24(12):1067-1069. PMID: 31668684
MH  - Animals
MH  - Arabidopsis/*immunology/*metabolism
MH  - Arabidopsis Proteins/agonists/antagonists & inhibitors/genetics/metabolism
MH  - Calcium/metabolism
MH  - Calcium Channel Blockers/metabolism/pharmacology
MH  - Calcium Signaling
MH  - Calmodulin/*metabolism/pharmacology
MH  - Cyclic Nucleotide-Gated Cation Channels/agonists/antagonists & 
      inhibitors/genetics/*metabolism
MH  - Female
MH  - Immunity, Innate
MH  - Oocytes/metabolism
MH  - Pathogen-Associated Molecular Pattern Molecules/*immunology
MH  - Phosphorylation
MH  - Plant Immunity/*immunology
MH  - Protein Serine-Threonine Kinases/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Xenopus
EDAT- 2019/07/19 06:00
MHDA- 2019/11/27 06:00
CRDT- 2019/07/19 06:00
PHST- 2017/12/30 00:00 [received]
PHST- 2019/06/25 00:00 [accepted]
PHST- 2019/07/19 06:00 [pubmed]
PHST- 2019/11/27 06:00 [medline]
PHST- 2019/07/19 06:00 [entrez]
AID - 10.1038/s41586-019-1413-y [pii]
AID - 10.1038/s41586-019-1413-y [doi]
PST - ppublish
SO  - Nature. 2019 Aug;572(7767):131-135. doi: 10.1038/s41586-019-1413-y. Epub 2019 Jul 
      17.