PMID- 31316508
OWN - NLM
STAT- MEDLINE
DCOM- 20201015
LR  - 20201015
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - Role of Dual-Specificity Phosphatase 1 in Glucocorticoid-Driven Anti-inflammatory 
      Responses.
PG  - 1446
LID - 10.3389/fimmu.2019.01446 [doi]
LID - 1446
AB  - Glucocorticoids (GCs) potently inhibit pro-inflammatory responses and are widely 
      used for the treatment of inflammatory diseases, such as allergies, autoimmune 
      disorders, and asthma. Dual-specificity phosphatase 1 (DUSP1), also known as 
      mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), exerts its effects 
      by dephosphorylation of MAPKs, i.e., extracellular-signal-regulated kinase (ERK), 
      p38, and c-Jun N-terminal kinase (JNK). Endogenous DUSP1 expression is tightly 
      regulated at multiple levels, involving both transcriptional and 
      post-transcriptional mechanisms. DUSP1 has emerged as a central mediator in the 
      resolution of inflammation, and upregulation of DUSP1 by GCs has been suggested 
      to be a key mechanism of GC actions. In this review, we discuss the impact of 
      DUSP1 on the efficacy of GC-mediated suppression of inflammation and address the 
      underlying mechanisms.
FAU - Hoppstadter, Jessica
AU  - Hoppstadter J
AD  - Department of Pharmacy, Pharmaceutical Biology, Saarland University, Saarbrucken, 
      Germany.
FAU - Ammit, Alaina J
AU  - Ammit AJ
AD  - Faculty of Science, School of Life Sciences, University of Technology Sydney, 
      Sydney, NSW, Australia.
AD  - Woolcock Emphysema Centre, Woolcock Institute of Medical Research, University of 
      Sydney, Sydney, NSW, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190626
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Glucocorticoids)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 3.1.3.48 (DUSP1 protein, human)
RN  - EC 3.1.3.48 (Dual Specificity Phosphatase 1)
SB  - IM
MH  - Dual Specificity Phosphatase 1/*immunology
MH  - Extracellular Signal-Regulated MAP Kinases/immunology
MH  - Gene Expression Regulation, Enzymologic/*immunology
MH  - Glucocorticoids/*immunology
MH  - Humans
MH  - Inflammation/immunology/pathology
MH  - MAP Kinase Signaling System/*immunology
PMC - PMC6611420
OTO - NOTNLM
OT  - COPD
OT  - arthritis
OT  - asthma
OT  - atherosclerosis
OT  - bone disease
OT  - infection
OT  - sepsis
EDAT- 2019/07/19 06:00
MHDA- 2020/10/21 06:00
PMCR- 2019/01/01
CRDT- 2019/07/19 06:00
PHST- 2019/04/15 00:00 [received]
PHST- 2019/06/10 00:00 [accepted]
PHST- 2019/07/19 06:00 [entrez]
PHST- 2019/07/19 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.01446 [doi]
PST - epublish
SO  - Front Immunol. 2019 Jun 26;10:1446. doi: 10.3389/fimmu.2019.01446. eCollection 
      2019.