PMID- 31318040
OWN - NLM
STAT- MEDLINE
DCOM- 20200415
LR  - 20210110
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 60
IP  - 8
DP  - 2019 Aug
TI  - The difficulty of diagnosing NCSE in clinical practice; external validation of 
      the Salzburg criteria.
PG  - e88-e92
LID - 10.1111/epi.16289 [doi]
AB  - To improve the diagnostic accuracy of electroencephalography (EEG) criteria for 
      nonconvulsive status epilepticus (NCSE), external validation of the recently 
      proposed Salzburg criteria is paramount. We performed an external, retrospective, 
      diagnostic accuracy study of the Salzburg criteria, using EEG recordings from 
      patients with and without a clinical suspicion of having NCSE. Of the 191 EEG 
      recordings, 12 (12%) was classified as an NCSE according to the reference 
      standard. In the validation cohort, sensitivity was 67% and specificity was 89%. 
      The positive predictive value was 47% and the negative predictive value was 95%. 
      Ten patients in the control group (n = 93) were false positive, resulting in a 
      specificity of 89.2%. The interrater agreement between the reference standards 
      and between the scorers of the Salzburg criteria was moderate; disagreement 
      occurred mainly in patients with an epileptic encephalopathy. The Salzburg 
      criteria showed a lower diagnostic accuracy in our external validation study than 
      in the original design, suggesting that they cannot replace the current practice 
      of careful weighing of both clinical and EEG information on an individual basis.
CI  - (c) 2019 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of 
      International League Against Epilepsy.
FAU - Goselink, Rianne J M
AU  - Goselink RJM
AUID- ORCID: 0000-0001-9640-6053
AD  - Department of Neurology and Clinical Neurophysiology, Radboud University Medical 
      Center, Donders Institute for Brain Cognition and Behaviour, Nijmegen, The 
      Netherlands.
AD  - Department of Neurology, Academic Center for Epileptology Kempenhaeghe & 
      Maastricht UMC+, Heeze, The Netherlands.
FAU - van Dillen, Jeroen J
AU  - van Dillen JJ
AD  - Department of Neurology and Clinical Neurophysiology, Radboud University Medical 
      Center, Donders Institute for Brain Cognition and Behaviour, Nijmegen, The 
      Netherlands.
FAU - Aerts, Marjolein
AU  - Aerts M
AD  - Department of Neurology and Clinical Neurophysiology, Radboud University Medical 
      Center, Donders Institute for Brain Cognition and Behaviour, Nijmegen, The 
      Netherlands.
FAU - Arends, Johan
AU  - Arends J
AD  - Department of Neurology, Academic Center for Epileptology Kempenhaeghe & 
      Maastricht UMC+, Heeze, The Netherlands.
FAU - van Asch, Charlotte
AU  - van Asch C
AD  - Department of Neurology, Academic Center for Epileptology Kempenhaeghe & 
      Maastricht UMC+, Heeze, The Netherlands.
FAU - van der Linden, Inge
AU  - van der Linden I
AD  - Department of Neurology, Academic Center for Epileptology Kempenhaeghe & 
      Maastricht UMC+, Heeze, The Netherlands.
FAU - Pasman, Jaco
AU  - Pasman J
AD  - Department of Neurology and Clinical Neurophysiology, Radboud University Medical 
      Center, Donders Institute for Brain Cognition and Behaviour, Nijmegen, The 
      Netherlands.
FAU - Saris, Christiaan G J
AU  - Saris CGJ
AD  - Department of Neurology and Clinical Neurophysiology, Radboud University Medical 
      Center, Donders Institute for Brain Cognition and Behaviour, Nijmegen, The 
      Netherlands.
FAU - Zwarts, Machiel
AU  - Zwarts M
AUID- ORCID: 0000-0003-3254-5438
AD  - Department of Neurology, Academic Center for Epileptology Kempenhaeghe & 
      Maastricht UMC+, Heeze, The Netherlands.
FAU - van Alfen, Nens
AU  - van Alfen N
AD  - Department of Neurology and Clinical Neurophysiology, Radboud University Medical 
      Center, Donders Institute for Brain Cognition and Behaviour, Nijmegen, The 
      Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20190718
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
CIN - Epilepsia. 2019 Nov;60(11):2337-2338. PMID: 31595488
CIN - Epilepsia. 2019 Nov;60(11):2334-2336. PMID: 31595496
MH  - Adolescent
MH  - Adult
MH  - Brain/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Electroencephalography/standards
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Reference Standards
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Status Epilepticus/*diagnosis/physiopathology
MH  - Young Adult
PMC - PMC6852511
OTO - NOTNLM
OT  - clinical study
OT  - diagnostic accuracy
OT  - epilepsy
OT  - nonconvulsive status epilepticus
COIS- None of the authors has any conflict of interest to disclose. We confirm that we 
      have read the Journal's position on issues involved in ethical publication and 
      affirm that this report is consistent with those guidelines.
EDAT- 2019/07/19 06:00
MHDA- 2020/04/16 06:00
PMCR- 2019/11/13
CRDT- 2019/07/19 06:00
PHST- 2019/01/25 00:00 [received]
PHST- 2019/06/25 00:00 [revised]
PHST- 2019/06/25 00:00 [accepted]
PHST- 2019/07/19 06:00 [pubmed]
PHST- 2020/04/16 06:00 [medline]
PHST- 2019/07/19 06:00 [entrez]
PHST- 2019/11/13 00:00 [pmc-release]
AID - EPI16289 [pii]
AID - 10.1111/epi.16289 [doi]
PST - ppublish
SO  - Epilepsia. 2019 Aug;60(8):e88-e92. doi: 10.1111/epi.16289. Epub 2019 Jul 18.