PMID- 31319000
OWN - NLM
STAT- MEDLINE
DCOM- 20200525
LR  - 20200525
IS  - 1365-2796 (Electronic)
IS  - 0954-6820 (Linking)
VI  - 286
IP  - 6
DP  - 2019 Dec
TI  - Angioedema associated with thrombolysis for ischemic stroke: analysis of a 
      case-control study.
PG  - 702-710
LID - 10.1111/joim.12962 [doi]
AB  - BACKGROUND: Bradykinin-mediated angioedema (AE) is a complication associated with 
      thrombolysis for acute ischemic stroke. Risk factors are unknown and management 
      is discussed. OBJECTIVES: To clarify risk factors associated with 
      bradykinin-mediated AE after thrombolysis for acute ischemic stroke. METHODS: In 
      a case-control study conducted at a French reference centre for bradykinin 
      angioedema, patients with thrombolysis for acute ischemic stroke and a diagnosis 
      of bradykinin-mediated angioedema, were compared to controls treated with 
      thrombolysis treatment without angioedema. RESULTS: Fifty-three 
      thrombolysis-related AE were matched to 106 control subjects. The sites of 
      attacks following thrombolysis for ischemic stroke mainly included tongue (34/53, 
      64%) and lips (26/53, 49%). The upper airways were involved in 37 (70%) cases. 
      Three patients required mechanical ventilation. Patients with bradykinin-mediated 
      angioedema were more frequently women [33 (62%) vs. 44 (42%); P = 0.01], had 
      higher frequency of prior ischemic stroke [12 (23%) vs. 9 (8%); P = 0.01], 
      hypertension [46 (87%) vs. 70 (66%); P = 0.005], were more frequently treated 
      with angiotensin-converting enzyme inhibitor [37 (70%) vs. 28 (26%); P < 0.001] 
      and were more frequently hospitalized in intensive care medicine [ICU; 11 (21%) 
      vs. 5 (5%); P = 0.004]. In multivariate analysis, factors associated with 
      thrombolysis-related AE were female sex [odds ratio (OR), 3.04; 95% confident 
      interval (CI), 1.32-7.01; P = 0.009] and treatment with angiotensin-converting 
      enzyme inhibitors [(OR), 6.08; 95% (CI), 2.17-17.07; P < 0.001]. CONCLUSIONS: 
      This case-control study points out angiotensin-converting enzyme inhibitors and 
      female sex as risk factors of bradykinin AE associated with thrombolysis for 
      ischemic stroke.
CI  - (c) 2019 The Association for the Publication of the Journal of Internal Medicine.
FAU - Vigneron, C
AU  - Vigneron C
AD  - From the, AP-HP, Medecine Interne, DHUi2B, Centre de Reference Associe sur les 
      Angioedemes a Kinines (CReAk), Hopital Saint-Antoine, Universite Paris 6, Paris, 
      France.
FAU - Lecluse, A
AU  - Lecluse A
AD  - Neurologie, CHU Angers, Angers, France.
FAU - Ronziere, T
AU  - Ronziere T
AD  - Neurologie, CHU Pontchaillou, Rennes, France.
FAU - Bouillet, L
AU  - Bouillet L
AD  - Medecine Interne, Centre de Reference sur les Angioedemes a Kinines (CReAk), CHU 
      de Grenoble, Grenoble, France.
FAU - Boccon-Gibod, I
AU  - Boccon-Gibod I
AD  - Medecine Interne, Centre de Reference sur les Angioedemes a Kinines (CReAk), CHU 
      de Grenoble, Grenoble, France.
FAU - Gayet, S
AU  - Gayet S
AD  - AP-HM, Medecine Interne, Centre de Competence Angioedemes non Histaminiques, 
      Hopital la Timone, Marseille, France.
FAU - Doche, E
AU  - Doche E
AD  - AP-HM, Neurologie, Hopital la Timone, Marseille, France.
FAU - Smadja, D
AU  - Smadja D
AD  - Neurologie, CH Sud Francilien, Corbeil-Essonnes, France.
FAU - Di Legge, S
AU  - Di Legge S
AD  - Neurologie, CH du Pays d'Aix-CH Intercommunal Aix-Pertuis, Aix-en-Provence, 
      France.
FAU - Dumont, F
AU  - Dumont F
AD  - Neurologie, CH Tourcoing, Tourcoing, France.
FAU - Gaudron, M
AU  - Gaudron M
AD  - Neurologie, CHU Tours, Tours, France.
FAU - Ion, I
AU  - Ion I
AD  - Neurologie, CHU Nimes, Nimes, France.
FAU - Marcel, S
AU  - Marcel S
AD  - Neurologie, CH Metropole Savoie, Chambery, France.
FAU - Sevin, M
AU  - Sevin M
AD  - Neurologie Institut du Thorax et du Systeme Nerveux, CHU Nantes, Nantes, France.
FAU - Vlaicu, M B
AU  - Vlaicu MB
AD  - AP-HP, Service de Neurochirurgie, Hopital Pitie Salpetriere, INSERM U955, Hopital 
      Orsay, Paris, France.
FAU - Launay, D
AU  - Launay D
AD  - U995-LIRIC-Lille Inflammation Research International Center, INSERM, U995, 
      Departement de Medecine Interne et Immunologie Clinique, Centre de Reference sur 
      les Angioedemes a Kinines (CReAk), Universite de Lille, CHU de Lille, Lille, 
      France.
FAU - Arnaud, I
AU  - Arnaud I
AD  - Neurologie, CHU Pointe-a-Pitre, Pointe-a-Pitre, France.
FAU - Girard-Madoux, P
AU  - Girard-Madoux P
AD  - Neurologie, L'hopital Nord-Ouest, Gleize, France.
FAU - Heroum, C
AU  - Heroum C
AD  - Neurologie, GH Portes-de-Provence, Montelimar, France.
FAU - Lefevre, S
AU  - Lefevre S
AD  - Institut d'allergologie, CHR Metz-Thionville, Metz, France.
FAU - Marc, G
AU  - Marc G
AD  - Neurologie, CH Saint-Nazaire, Saint-Nazaire, France.
FAU - Obadia, M
AU  - Obadia M
AD  - Neurologie, Fondation Ophtalmologique Rothschild, Paris, France.
FAU - Sablot, D
AU  - Sablot D
AD  - Neurologie, CH Perpignan, Perpignan, France.
FAU - Sibon, I
AU  - Sibon I
AD  - Neurologie, CHU Bordeaux, Universite de Bordeaux, Bordeaux, France.
FAU - Suissa, L
AU  - Suissa L
AUID- ORCID: 0000-0003-2345-8711
AD  - Neurologie, CHU Nice, Nice, France.
FAU - Gobert, D
AU  - Gobert D
AD  - From the, AP-HP, Medecine Interne, DHUi2B, Centre de Reference Associe sur les 
      Angioedemes a Kinines (CReAk), Hopital Saint-Antoine, Universite Paris 6, Paris, 
      France.
FAU - Detante, O
AU  - Detante O
AD  - Neurologie, CHU de Grenoble, Grenoble, France.
FAU - Alamowitch, S
AU  - Alamowitch S
AD  - AP-HP, Service de Neurologie, Hopital Saint-Antoine, Sorbonne Universites, UPMC 
      Univ Paris 06, UMRS 938, Paris, France.
FAU - Fain, O
AU  - Fain O
AD  - From the, AP-HP, Medecine Interne, DHUi2B, Centre de Reference Associe sur les 
      Angioedemes a Kinines (CReAk), Hopital Saint-Antoine, Universite Paris 6, Paris, 
      France.
FAU - Javaud, N
AU  - Javaud N
AUID- ORCID: 0000-0003-2580-1499
AD  - AP-HP, Urgences, CreAk, Hopital Louis Mourier, Universite Paris 7, Colombes, 
      France.
LA  - eng
PT  - Journal Article
DEP - 20190802
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Aged
MH  - Angioedema/*chemically induced
MH  - Angiotensin-Converting Enzyme Inhibitors/*adverse effects
MH  - Bradykinin
MH  - Brain Ischemia/*drug therapy
MH  - Case-Control Studies
MH  - Female
MH  - France
MH  - Humans
MH  - Male
MH  - Risk Factors
MH  - Sex Factors
MH  - Stroke/*drug therapy
MH  - Thrombolytic Therapy/*adverse effects
OTO - NOTNLM
OT  - alteplase
OT  - angioedema
OT  - bradykinin
OT  - ischemic stroke
EDAT- 2019/07/19 06:00
MHDA- 2020/05/26 06:00
CRDT- 2019/07/19 06:00
PHST- 2019/07/19 06:00 [pubmed]
PHST- 2020/05/26 06:00 [medline]
PHST- 2019/07/19 06:00 [entrez]
AID - 10.1111/joim.12962 [doi]
PST - ppublish
SO  - J Intern Med. 2019 Dec;286(6):702-710. doi: 10.1111/joim.12962. Epub 2019 Aug 2.