PMID- 31319164
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200210
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 27
DP  - 2019 Sep
TI  - Comparison of different laser-based photochemical systems for periodontal 
      treatment.
PG  - 433-439
LID - S1572-1000(19)30047-X [pii]
LID - 10.1016/j.pdpdt.2019.06.009 [doi]
AB  - PURPOSE: The main aim in periodontitis treatment is to remove supragingival and 
      subgingival biofilm. Mechanical treatment to eliminate pathogenic bacteria is 
      limited by morphological conditions on the root surface. This study assessed the 
      antibacterial effectiveness of different laser-based photochemical systems, 
      particularly a novel curcumin-based option. METHODS: Ninety-one titanium bars 
      were inoculated with an artificial biofilm of common pathogenic periodontal 
      bacteria and inserted into an artificial periodontal pocket model. The following 
      groups (n = 13) were tested: 1, curcumin solution plus SLB laser irradiation 
      (C + L; 445 nm, 0.6 W, 25% duty cycle, 100 Hz, 10 s); 2, curcumin solution (Cur); 
      3, dimethyl sulfoxide solution (DMSO); 4, SiroLaser Blue (SLB) - laser 
      irradiation (445 nm, 0.6 W, 25% duty cycle, 100 Hz, 10 s); 5, antimicrobial 
      photodynamic therapy (aPDT); 6, antimicrobial photothermal therapy (aPTT); 7, 
      control. The samples were stored in Eppendorf tubes and analyzed 
      microbiologically using quantitative real-time polymerase chain reaction (PCR). 
      The main parameter for analyzing group differences was the total bacterial load. 
      Statistical analysis was performed with nonparametric methods. RESULTS: 
      Statistically significant reductions in bacterial count were observed in all 
      experimental groups (p < 0.05). The mean percentage reductions were as follows: 
      SLB, 95.03%; aPDT, 83.91%; DMSO, 95.69%; C + L, 97.15%. No statistically 
      significant differences in bacteria reduction were observed for laser alone 
      (SLB), DMSO, or curcumin with or without additional laser irradiation. 
      CONCLUSIONS: The greatest antibacterial efficacy was observed in samples treated 
      with aPTT. Using curcumin as a photosensitizing agent for 445 nm laser 
      irradiation did not result in improved antibacterial effectiveness in comparison 
      with laser alone.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Bocher, Sarah
AU  - Bocher S
AD  - Department of Operative Dentistry, Periodontology and Preventive Dentistry, RWTH 
      Aachen University, Germany; Department of Operative Dentistry and Endodontology, 
      University of Marburg, Georg-Voigt-Strasse 3, 35039 Marburg, Germany.
FAU - Wenzler, Johannes-Simon
AU  - Wenzler JS
AD  - Department of Operative Dentistry, Periodontology and Preventive Dentistry, RWTH 
      Aachen University, Germany.
FAU - Falk, Wolfgang
AU  - Falk W
AD  - Oro-Dental Microbiology, Kiel, Germany.
FAU - Braun, Andreas
AU  - Braun A
AD  - Department of Operative Dentistry, Periodontology and Preventive Dentistry, RWTH 
      Aachen University, Germany. Electronic address: anbraun@ukaachen.de.
LA  - eng
PT  - Journal Article
DEP - 20190715
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Photosensitizing Agents)
RN  - IT942ZTH98 (Curcumin)
RN  - IX6J1063HV (Indocyanine Green)
RN  - T42P99266K (Methylene Blue)
RN  - YOW8V9698H (Dimethyl Sulfoxide)
SB  - IM
MH  - Biofilms/*drug effects
MH  - Curcumin/*therapeutic use
MH  - Dimethyl Sulfoxide/therapeutic use
MH  - Humans
MH  - Hyperthermia, Induced/*methods
MH  - Indocyanine Green/therapeutic use
MH  - Lasers, Semiconductor
MH  - Methylene Blue/therapeutic use
MH  - Periodontal Pocket/*drug therapy
MH  - Photochemotherapy/*methods
MH  - Photosensitizing Agents/*therapeutic use
MH  - Real-Time Polymerase Chain Reaction
OTO - NOTNLM
OT  - Antimicrobial photodynamic therapy (aPDT)
OT  - Antimicrobial photothermal therapy (aPTT)
OT  - Curcumin
OT  - Indocyanine green (ICG)
OT  - Laser irradiation
OT  - Methylene blue
EDAT- 2019/07/19 06:00
MHDA- 2020/02/11 06:00
CRDT- 2019/07/19 06:00
PHST- 2019/03/25 00:00 [received]
PHST- 2019/06/08 00:00 [revised]
PHST- 2019/06/14 00:00 [accepted]
PHST- 2019/07/19 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/07/19 06:00 [entrez]
AID - S1572-1000(19)30047-X [pii]
AID - 10.1016/j.pdpdt.2019.06.009 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2019 Sep;27:433-439. doi: 
      10.1016/j.pdpdt.2019.06.009. Epub 2019 Jul 15.