PMID- 31319607
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 11
IP  - 7
DP  - 2019 Jul 17
TI  - Prognostic Impact of Melatonin Receptors MT1 and MT2 in Non-Small Cell Lung 
      Cancer (NSCLC).
LID - 10.3390/cancers11071001 [doi]
LID - 1001
AB  - Background: Several studies have investigated the inhibitory effect of melatonin 
      on lung cancer cells. There are no data available on the prognostic impact of 
      melatonin receptors MT1 and MT2 in non-small cell lung cancer (NSCLC). Materials 
      and Methods: Immunohistochemical studies of MT1 and MT2 were conducted on NSCLC 
      (N = 786) and non-malignant lung tissue (NMLT) (N = 120) using tissue 
      microarrays. Molecular studies were performed on frozen fragments of NSCLC (N = 
      62; real time PCR), NMLT (N = 24) and lung cancer cell lines NCI-H1703, A549 and 
      IMR-90 (real time PCR, western blot). Results: The expression of both receptors 
      was higher in NSCLC than in NMLT. Higher MT1 and MT2 expression levels (at 
      protein and mRNA) were noted in squamous cell carcinomas (SCC) compared to 
      adenocarcinomas (AC). MT1 immunoexpression decreased as both the tumour size and 
      the cancer stage increased in the whole cohort, while MT2 decreased as the cancer 
      stage increased, with lymph node involvement (in the whole study group) and 
      increasing malignancy grade (in SCC). Higher expression of MT2 was associated 
      with a favorable prognosis. MT2 was an independent prognostic factor for overall 
      survival (OS) in all analyzed NSCLC and in smoking patients. Conclusions: Our 
      observations may point to the potential prognostic significance of MT2 in NSCLC.
FAU - Jablonska, Karolina
AU  - Jablonska K
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland. 
      karolina.jablonska@umed.wroc.pl.
FAU - Nowinska, Katarzyna
AU  - Nowinska K
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland. 
      katarzyna.nowinska@umed.wroc.pl.
FAU - Piotrowska, Aleksandra
AU  - Piotrowska A
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
FAU - Partynska, Aleksandra
AU  - Partynska A
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
FAU - Katnik, Ewa
AU  - Katnik E
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
FAU - Pawelczyk, Konrad
AU  - Pawelczyk K
AD  - Department of Thoracic Surgery, Wroclaw Medical University, 53-439 Wroclaw, 
      Poland.
AD  - Department of Thoracic Surgery, Lower Silesian Centre of Lung Diseases, 53-439 
      Wroclaw, Poland.
FAU - Glatzel-Plucinska, Natalia
AU  - Glatzel-Plucinska N
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
FAU - Podhorska-Okolow, Marzenna
AU  - Podhorska-Okolow M
AD  - Division of Ultrastructure Research, Wroclaw Medical University, 50-368 Wroclaw, 
      Poland.
FAU - Dziegiel, Piotr
AU  - Dziegiel P
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
AD  - Department of Physiotherapy, University School of Physical Education, 51-612 
      Wroclaw, Poland.
LA  - eng
GR  - STM.A110.17.027/Wroclaw Medical University/
PT  - Journal Article
DEP - 20190717
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC6679108
OTO - NOTNLM
OT  - MT1
OT  - MT2
OT  - cancer
OT  - immunohistochemistry
OT  - melatonin
OT  - melatonin receptor
OT  - non-small cell lung carcinoma
COIS- The Authors have no conflicts of interest to declare.
EDAT- 2019/07/20 06:00
MHDA- 2019/07/20 06:01
PMCR- 2019/07/17
CRDT- 2019/07/20 06:00
PHST- 2019/05/14 00:00 [received]
PHST- 2019/07/09 00:00 [revised]
PHST- 2019/07/15 00:00 [accepted]
PHST- 2019/07/20 06:00 [entrez]
PHST- 2019/07/20 06:00 [pubmed]
PHST- 2019/07/20 06:01 [medline]
PHST- 2019/07/17 00:00 [pmc-release]
AID - cancers11071001 [pii]
AID - cancers-11-01001 [pii]
AID - 10.3390/cancers11071001 [doi]
PST - epublish
SO  - Cancers (Basel). 2019 Jul 17;11(7):1001. doi: 10.3390/cancers11071001.