PMID- 31319676
OWN - NLM
STAT- MEDLINE
DCOM- 20200710
LR  - 20240402
IS  - 1938-2731 (Electronic)
IS  - 1533-3175 (Print)
IS  - 1533-3175 (Linking)
VI  - 34
IP  - 7-8
DP  - 2019 Nov-Dec
TI  - Decreased Levels of Serum IGF-1 and Vitamin D Are Associated With Cognitive 
      Impairment in Patients With Type 2 Diabetes.
PG  - 450-456
LID - 10.1177/1533317519860334 [doi]
AB  - PURPOSE: To determine the association of serum insulin-like growth factor 1 
      (IGF-1) and vitamin D levels with cognition status in patients with type 2 
      diabetes mellitus (T2DM). METHODS: A total of 173 patients with T2DM were 
      recruited and divided into mild cognitive impairment (MCI) group (n = 94) and 
      normal cognition (NC) group (n = 79). Levels of IGF-1 and 25(OH)D were measured 
      and compared, and the correlations among IGF-1, 25(OH)D, and cognitive function 
      were analyzed. RESULTS: Insulin-like growth factor 1 and 25(OH)D levels 
      significantly decreased in MCI group than those in the NC group (both P < .001). 
      Multiple stepwise regression analysis revealed that IGF-1 (beta = .146, P < .001) 
      and 25(OH)D (beta = .199, P < .001) independently predicted Montreal Cognitive 
      Assessment (MoCA) scores. Partial least square regression showed that 
      contributions of both 25(OH)D (P < .001) and IGF-1 (P < .001) to MoCA scores were 
      significant, while no cross-effect was observed between them (P = .714). 
      CONCLUSIONS: Low serum IGF-1 and 25(OH)D levels may separately predict poor 
      cognitive performance in patients with diabetes.
FAU - Rui-Hua, Chen
AU  - Rui-Hua C
AD  - Department of Endocrinology, Shanghai General Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Yong-de, Peng
AU  - Yong-de P
AUID- ORCID: 0000-0001-5483-7007
AD  - Department of Endocrinology, Shanghai General Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Xiao-Zhen, Jiang
AU  - Xiao-Zhen J
AD  - Department of Endocrinology, Shanghai Pudong New Area People's Hospital, 
      Shanghai, China.
FAU - Chen, Jason
AU  - Chen J
AD  - JMP China Division, SAS Institute Inc, Cary, NC, USA.
FAU - Bin, Zhou
AU  - Bin Z
AD  - Department of Endocrinology, Shanghai Pudong New Area People's Hospital, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190718
PL  - United States
TA  - Am J Alzheimers Dis Other Demen
JT  - American journal of Alzheimer's disease and other dementias
JID - 101082834
RN  - 0 (IGF1 protein, human)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - Aged
MH  - Calcifediol/*blood
MH  - Cognitive Dysfunction/*blood/etiology
MH  - Diabetes Complications/*blood
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Middle Aged
PMC - PMC10653368
OTO - NOTNLM
OT  - IGF-1
OT  - Montreal Cognitive Assessment
OT  - diabetes mellitus
OT  - mental status and dementia tests
OT  - mild cognitive impairment
OT  - type 2
OT  - vitamin D
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2019/07/20 06:00
MHDA- 2020/07/11 06:00
PMCR- 2019/07/18
CRDT- 2019/07/20 06:00
PHST- 2019/07/20 06:00 [pubmed]
PHST- 2020/07/11 06:00 [medline]
PHST- 2019/07/20 06:00 [entrez]
PHST- 2019/07/18 00:00 [pmc-release]
AID - 10.1177_1533317519860334 [pii]
AID - 10.1177/1533317519860334 [doi]
PST - ppublish
SO  - Am J Alzheimers Dis Other Demen. 2019 Nov-Dec;34(7-8):450-456. doi: 
      10.1177/1533317519860334. Epub 2019 Jul 18.