PMID- 31321283
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 23
DP  - 2019 Jun
TI  - Electrophysiology study for risk stratification in patients with cardiac 
      sarcoidosis and abnormal cardiac imaging.
PG  - 100342
LID - 10.1016/j.ijcha.2019.03.002 [doi]
LID - 100342
AB  - BACKGROUND: Abnormalities on cardiac imaging (cardiac magnetic resonance imaging 
      [CMR] or positron emission tomography [PET]), left ventricular ejection fraction 
      (LVEF), and electrophysiology study (EPS) all predict ventricular arrhythmias 
      (VA) in patients with cardiac sarcoidosis (CS). We sought to assess the utility 
      of EPS in patients with CS and abnormal cardiac imaging, focusing on those with 
      LVEF >35%. METHODS: We identified all patients treated at our institution from 
      2000 to 2017 who: 1.) had probable or definite CS; 2.) had either late gadolinium 
      enhancement (LGE) on CMR or abnormal 18-flourodeoxyglucose (FDG) uptake on PET, 
      and 3.) had undergone EPS. The primary endpoint was VA during follow up. RESULTS: 
      Twenty five patients were included, of whom 10 (40%) had positive EPS. During a 
      mean follow-up of 4.8 +/- 3.4 years, 11 (44%) patients had VA. The positive 
      predictive value (PPV) of EPS for VA was 100% and the negative predictive value 
      (NPV) of EPS for VA was 93%. Among 12 patients with LVEF >35% and no prior VA, 
      the PPV of EPS for VA was 100% and the NPV of EPS for VA was 90%. CONCLUSION: EPS 
      may help with risk stratification in patients with CS and abnormal imaging, 
      especially those without conventional indications for ICD placement. Among 
      patients with LVEF >35% and no history of prior VA, a negative EPS has good 
      positive and negative predictive value for future VA events.
FAU - Okada, David R
AU  - Okada DR
AD  - Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, 
      Baltimore, MD, United States of America.
FAU - Smith, John
AU  - Smith J
AD  - Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, 
      Baltimore, MD, United States of America.
FAU - Derakhshan, Arsalan
AU  - Derakhshan A
AD  - Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, 
      Baltimore, MD, United States of America.
FAU - Gowani, Zain
AU  - Gowani Z
AD  - Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, 
      Baltimore, MD, United States of America.
FAU - Zimmerman, Stefan L
AU  - Zimmerman SL
AD  - Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, United States of 
      America.
FAU - Misra, Satish
AU  - Misra S
AD  - Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, 
      Baltimore, MD, United States of America.
FAU - Berger, Ronald D
AU  - Berger RD
AD  - Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, 
      Baltimore, MD, United States of America.
FAU - Calkins, Hugh
AU  - Calkins H
AD  - Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, 
      Baltimore, MD, United States of America.
FAU - Tandri, Harikrishna
AU  - Tandri H
AD  - Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, 
      Baltimore, MD, United States of America.
FAU - Chrispin, Jonathan
AU  - Chrispin J
AD  - Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, 
      Baltimore, MD, United States of America.
LA  - eng
PT  - Journal Article
DEP - 20190316
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC6612749
OTO - NOTNLM
OT  - Cardiac sarcoidosis
OT  - Electrophysiology study
OT  - Implantable cardioverter defibrillator
OT  - Sudden cardiac death
OT  - Ventricular arrhythmia
EDAT- 2019/07/20 06:00
MHDA- 2019/07/20 06:01
PMCR- 2019/03/16
CRDT- 2019/07/20 06:00
PHST- 2019/01/23 00:00 [received]
PHST- 2019/02/14 00:00 [revised]
PHST- 2019/03/07 00:00 [accepted]
PHST- 2019/07/20 06:00 [entrez]
PHST- 2019/07/20 06:00 [pubmed]
PHST- 2019/07/20 06:01 [medline]
PHST- 2019/03/16 00:00 [pmc-release]
AID - S2352-9067(19)30058-2 [pii]
AID - 100342 [pii]
AID - 10.1016/j.ijcha.2019.03.002 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2019 Mar 16;23:100342. doi: 
      10.1016/j.ijcha.2019.03.002. eCollection 2019 Jun.